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临床试验/NCT05109273
NCT05109273已完成不适用

Atrioventricular Nodal Reentrant Tachycardia Ablation With irrigATEd catheteR And Three-dimensional elecTroAnatomiC Mapping (WATER ATTAC)

University Hospital of Ferrara2 个研究点 分布在 1 个国家目标入组 289 人开始时间: 2021年12月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
289
试验地点
2
主要终点
Procedural complication

研究概览

简要总结

The WATER ATTAC study aims at multicentric, longitudinal, perspective evaluation of safety and efficacy of atrioventricular nodal reentrant tachycardia (AVNRT) performed combining irrigated ablation catheter and three-dimensional electroanatomic mapping system. Efficacy and rate of complications will be evaluated over medium and long term follow-up.

详细描述

Atrioventricular nodal reentrant tachycardia (AVNRT) is the most common supraventricular tachycardia in clinical practice, more common in women than in men. It can occur at all ages, but it is more likely to begin in young adults, with average age of onset around 32 years. Due to its sudden onset and cessation it is classified in the group of paroxysmal supraventricular tachycardias (PSVT), accounting for almost two thirds of the total.

AVNRT is a regular supraventricular tachycardia resulting from formation of reentry circuit confined to atrioventricular node and perinodal atrial tissue. About 80-90% of patients with AVNRT have the common form of arrhythmia, also called "typical" or "slow-fast" type.

Slow-fast AVNRT usually begins when premature atrial complex (PAC) arrives at AV node when fast pathway is in its refractory period. Therefore, antegrade conduction along fast pathway is blocked. If premature beat arrives in specific time window, slow pathway, with shorter refractory period, is available for conduction to ventricle. Premature beat leads through slow way, and, through final common way, to His bundle. As a result, PR interval of premature beat will be longer than normal beats conducted through fast track. If fast pathway has recovered its excitability by the time impulse of the slow pathway reaches distal junction of the two paths, impulse can lead retrograde through fast pathway. Circuit can then become repetitive with antegrade conduction along slow pathway and retrograde conduction along fast pathway with consequent triggering of sustained tachycardia. This proposed mechanism explains series of clinical observations of AVNRTs: single PAC can initiate arrhythmia and in the same way penetration in reentry circuit by PAC can abruptly interrupt arrhythmia.

Up to 20% of patients with AVNRT have uncommon forms of arrhythmia, referred to as "atypical" AVNRT. There are cases in which antegrade conduction can occur along fast pathway with retrograde conduction along slow pathway (fast-slow type).

Some patients, on the other hand, have more slow pathways, in which both antegrade and retrograde pathways of circuit use slow AV nodal pathways (slow-slow type).

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients undergoing electrophysiologic study (EPS) for paroxysmal supraventricular tachycardia
  • evidence of dual AV node pathway or atrioventricular nodal reentrant tachycardia (AVNRT) induction at EPS
  • Attempt of AVNRT ablation with irrigated catheter and three-dimensionale electroanatomic mapping system

排除标准

  • Age <18 years
  • Ablation with non-irrigated catheter
  • Ablation without electroanatomic mapping system

结局指标

主要结局

Procedural complication

时间窗: 12 months

AV iatrogenic block

Procedural success

时间窗: 12 months

Recurrence of AVNRT during follow-up

次要结局

  • Acute success rate(Immediate post-procedure)

研究者

发起方
University Hospital of Ferrara
申办方类型
Other
责任方
Principal Investigator
主要研究者

Matteo Bertini

Principal Investigator

University Hospital of Ferrara

研究点 (2)

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