The Effect of an 8-Week Germinated Black Hang Rice Extract Consumption on Cognitive Functions in Healthy Middle-Aged and Elderly Volunteers: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
- Conditions
- healthy human volunteersWorking memory, acetylcholinesterase, monoamine oxidase
- Registration Number
- TCTR20230206003
- Lead Sponsor
- Rajamangala university of technology Isan
- Brief Summary
HME could promote learning and memory. The possible mechanism might have occurred primarily via the suppression of AChE and MAO levels.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 24
1. Subjects: Aged 45-70 years, 2. Healthy status, 3. Located in the northeastern region of Thailand., 4. Two days before the testing, it is prohibited to consume tea, coffee, or alcohol for at least 12 hours., 5. Montreal Cognitive Assessment (MoCA) Test more than 26
1. Cardiovascular diseases, respiratory diseases, neuropsychological diseases, head injury, diabetes mellitus, liver disease, cancer, autoimmune disease, and hematological disorder, 2. Receiving drugs or hormones, dietary supplements, or other types of herbal medicines that affect the nervous system during the trial and within three months prior to the start of the trial, 3. Alcohol abuse, 4. Smoking status (more than 10 cigarettes per day), 5. In the process of collaborating with different projects.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method working memory at week-4 and week-8 Computerized Battery Test.
- Secondary Outcome Measures
Name Time Method Acetylcholinesterase (AChE) Activity and Monoamine Oxidase Activity Baseline and week 8 Biochemical Assays,Clinical safety assessment Baseline and week-8 biochemistry and hematology