Effect of Ventilation Mode on Lung Deposition of a Radiolabeled Aerosol During Mechanical Ventilation: Barometric Versus Volumetric

Not Applicable

Completed

• Conditions: Post-operative Neurosurgery
• Interventions: Drug: technetium-99m - Diethylenetriaminepentaacetic acid; Device: Vibrating-mesh nebulizer; Other: Gamma scintigraphy; Other: Preoperative spirometry

• Registration Number: NCT01879488
• Lead Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Brief Summary

Controlling the respiratory pattern of mechanically ventilated patients in volume control mode is recommended during nebulization. No studies looked into conditions of nebulization during assisted mechanical ventilation to define the optimal nebulization technique and its effect on pulmonary deposition.

The aim of this study is to analyse the effect of ventilation mode (barometric versus volumetric) on deposition by planar scintigraphy during mechanical ventilation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-06-10
• Study First Submitted QC: 2013-06-13
• Study First Posted: 2013-06-17
• Study Start: 2013-07
• Primary Completion: 2015-06
• Study Completion: 2015-06
• Status Verified: 2015-11
• Last Update Submitted: 2015-11-16
• Last Update Posted: 2015-11-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 19

Inclusion Criteria

• Invasive mechanical ventilation
• Healthy lungs

Exclusion Criteria

• Change of ventilation mode during nebulization

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Nebulization during pressure support ventilation	technetium-99m - Diethylenetriaminepentaacetic acid	Patients ventilated in pressure support mode during nebulization
Nebulization during pressure support ventilation	Vibrating-mesh nebulizer	Patients ventilated in pressure support mode during nebulization
Nebulization during pressure support ventilation	Gamma scintigraphy	Patients ventilated in pressure support mode during nebulization
Nebulization during pressure support ventilation	Preoperative spirometry	Patients ventilated in pressure support mode during nebulization
Nebulization during volume assist control mode	technetium-99m - Diethylenetriaminepentaacetic acid	Patients ventilated in volume assist control mode during nebulization
Nebulization during volume assist control mode	Vibrating-mesh nebulizer	Patients ventilated in volume assist control mode during nebulization
Nebulization during volume assist control mode	Gamma scintigraphy	Patients ventilated in volume assist control mode during nebulization
Nebulization during volume assist control mode	Preoperative spirometry	Patients ventilated in volume assist control mode during nebulization

Primary Outcome Measures

Name	Time	Method
Pulmonary deposition	Immediately after nebulization by imaging assessment, an expected average of 30 minutes

Secondary Outcome Measures

Name	Time	Method
Penetration index	Immediately after nebulization by imaging assessment, an expected average of 30 minutes
Lung function	Preoperative assessment, the day before inclusion
Mechanical ventilation settings	During nebulisation time, an expected average of 15 minutes

Trial Locations

Locations (1)

Cliniques Universitaires Saint-Luc; 🇧🇪 Brussels, Belgium