nraveling the effects of rhythmic external cueing on mobility: synchronisation and use of alternative circuitry in the parkinsonian brain.

Phase 2

Conditions: Parkinson's Disease
10029317

Registration Number: NL-OMON29887

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 45

Inclusion Criteria

Patients: 1) Modified Hoehn and Yahr stage ranging from 2 to 4; 2) a stable medication regime;
All: 3) age under 70 years; 4) sufficient orientation in time and place (Minimal Mental State Examination (MMSE) * 26) , 5) completion of an informed consent for participation, and 6) able to walk 10 meter independently.

Exclusion Criteria

Patients: 1) Presence of severe dyskinesia (Modified Dyskinesia Scale score >1),
All: 2) any (other) neurological, cardiovascular or orthopaedic disorder or other co-morbidity that may influence mobility and would interfere with participation ,3) presence of medical implants such as pacemakers, 4) inability to communicate (written of verbally) in the Dutch language and 5) history fo epilepsy

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Group and condition differences in 1) localization, latency and amplitude of<br /><br>evoked cortical potentials, 2) spectral power over different frequency bands,<br /><br>3) cortico-cortical synchronization patterns (e.g. interregional coupling or<br /><br>correlation, synchronization likelihood, coherence ), 4) blood oxygen<br /><br>level-dependent (BOLD) MRI signal changes.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Group differences in changes in performance on motor paradigm after rTMS (hand<br /><br>movement speed, timing of hand movement to cues and walking speed, cadence and<br /><br>stride length).</p><br>