The effect of treatment of neonatal electrographic seizures, detected with the continuous cerebral function monitoring, with respect to occurrence of postneonatal epilepsy and neurodevelopmental outcome.

Completed

Conditions: neonatal seizures in fullterm infants following perinatal asphyxia

Registration Number: NL-OMON24610

Brief Summary: Van Rooij LCM, Toet MC, Rademaker MCA, Groenendaal, de Vries LS. Cardiac arrhythmia in Neonates Receiving Lidocaine as Anticonvulsive Treatment. Eur J Pediatr 2004Eur J Pediatr. 2004;163:637-41. <br> van Rooij LG, Toet MC, Osredkar D, van Huffelen AC, Groenendaal F, de Vries LS.Recovery of amplitude integrated electroencephalographic background patterns within 24 hours of perinatal asphyxia.Arch Dis Child Fetal Neonatal Ed. 2005;90:F245-51. <br> Toet MC, Groenendaal F, Osredkar D, van Huffelen AC, de Vries LS.Postneonatal epilepsy following amplitude-integrated EEG-detected neonatal seizures Pediatr Neurol 2005; 32:241-7

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 120

Inclusion Criteria

Fullterm infants admitted to the neonatal intensive care unit, within the first 24 hours after birth with subclinical seizures on the aEEG, in 8 Dutch and 3 Belgium centres.

Exclusion Criteria

Preterm infants (<37 wks GA) and fullterm infants with neonatal seizures admitted after the first 24 hours after birth. Infants with chromosomal disorders, congenital anomalies and meningitis.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. What is the number of electrographic seizure discharges missed if you do not monitor continuously; <br /><br>2. Does instantaneous treatment of electrographical seizures lead to: <br /><br>a. A reduction of seizure discharges; <br /><br>b. Less damage on the neonatal MRI.

Secondary Outcome Measures