Comparison Of Analgesic Efficacy Of Transdermal Buprenorphine For Postoperative Pain With Control Group In Patients Undergoing Lumbar Discectomy

Transdermal patches for NSAIDS and opioids offer the advantage of sustained drug delivery, bioavailability, and avoidance of first-pass metabolism which reduces systemic effects. They have a one-time application, reduce workload on health-care workers, and prevent waxing-waning of analgesia due to diminishing blood levels.It has been widely applied in treating chronic low back pain displaying excellent results.This study is undertaken to see the effect of transdermal buprenorphine on postoperative pain after lumbar discectomy.

Patients posted for lumbar discectomy in Sapthagiri Institute of Medical Sciences  who fulfil the inclusion criteria will be enrolled for the study. Patients will be randomised into 2 equal groups of 42 each  [Group B and Group C] using computer generated table of random numbers.

Group B: Receiving transdermal buprenorphine patch 10 mg the night before surgery

Group C : Control group who will not receive buprenorphine patch

Group B patients will receive transdermal Buprenorphine 10mcg/hr patch night before surgery. Analgesia IV Paracetamol 1g  will be given after intubation in both groups. Intraoperative hemodynamic parameters like HR , BP , SPO2  will be noted at baseline, induction, 5 mins and 10 mins. VAS score , HR , BP , SPO2 will be assessed at 0, 2, 4, 8, 12, 24 and 48hrs in both the groups and recorded. Inj Tramadol 2 mg/kg (maximum 100mg) IV will be administered when VAS>3 as rescue analgesic.VAS score, time of first rescue analgesia, total analgesic consumption will be recorded in  first 48 hours and compared between both groups.

---