Augmentation of Interpersonal Psychotherapy (IPT) with D-cycloserine
- Conditions
- F33.2F32.2Severe depressive episode without psychotic symptomsRecurrent depressive disorder, current episode severe without psychotic symptoms
- Registration Number
- DRKS00007910
- Lead Sponsor
- niversitätsklinikum Freiburg; Sponsordelegation an Prof. Dr. Claus Normann
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting withdrawn before recruiting started
- Sex
- All
- Target Recruitment
- 28
Major depressive disorder (ICD-10: F32.2 and F33.2)
- Inpatients at the Department of Psychiatry and Psychotherapy, Freiburg
- Score of =15 and = 45 on the 21-item Hamilton Rating Scale for Depression (HAMD)
- 20-60 years of age
- Ability to provide informed consent
- Absence of any exclusion criteria
Hypersensitivity to D-cycloserine
- Neurological disorders including epilepsy, history of brain injury, encephalitis, or any organic brain syndrome
- Metallic implants
- Present pregnancy
- DSM-V axis I disorder (lifetime) apart from major depression, such as schizophrenia, schizoaffective disorder, any non-bipolar psychotic disorder, bipolar disorders, primary anxiety or obsessive compulsive disorder, mental retardation, signs of impaired cognitive functioning
- Acute suicidality
- Psychotic features of MDD
- Lifetime history for drug/alcohol dependence, or drug/alcohol abuse within the past year - Antidepressive pharmacotherapy other than monotherapy with SSRI, bupropion or venlafaxine
- Medical conditions including severe cardiac, liver, kidney, endocrine (e.g., diabetes), hematologic disorders (e.g., porphyria or any bleeding abnormalities), other impairing or unstable medical condition or impending surgery
- Inability to read or understand the study forms and agree to informed consent.
- Left-handedness
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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