CTRI/2025/07/091554尚未招募不适用
TO EVALUATE EFFECT OF MECHANICAL POWER DIRECTED LUNG PROTECTIVE VENTILATION STRATEGY ON TREATMENT OUTCOME IN PATIENTS WITH ACUTE RESPIRATORY FAILURE- A PROSPECTIVE STUDY
FORTIS ESCORTS HEART INSTITUTE1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2025年8月15日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Mortality
研究概览
简要总结
Mechanical ventilation is potentially life saving therapy for patients with acute respiratory failure. But unfortunately this invasive procedure has induced further lung injury- termed as ventilator induced lung injury (VILI). Thus it has become imperative that ventilator parameters should be adjusted to optimize gas exchange and with an attempt to minimize injury.The amount of energy per unit time, expressed as joules/minute is ,referred as mechanical power.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with Acute respiratory failure (ARF), defined as the ratio of partial pressure of oxygen (PaO2) to fraction of inspired oxygen (FiO2) less than 300 mmHg on admission, who will receive invasive mechanical ventilation for more than 48 hrs.
排除标准
- •Received treatment with extracorporeal life support;
- •Age less than 18 years; or
- •Mechanical power ≤ 10 J/min on admission (with a possible lower risk of lung injury).
结局指标
主要结局
Mortality
时间窗: baseline,4 weeks
次要结局
- Mechanical power(baseline, after 24 hours)
研究者
SRIPARNA MANDAL
FORTIS ESCORTS HEART INSTITUTE, DEPARTMENT OF CRITICAL CARE MEDICINE, DELHI
研究点 (1)
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