End-range Mobilization on Knee Osteoarthritis

Not Applicable

Completed

• Conditions: Osteo Arthritis Knee
• Interventions: Procedure: Conservative therapy; Procedure: Manual therapy

• Registration Number: NCT04270253
• Lead Sponsor: University of Pecs

Brief Summary

Different manual therapy techniques and conservative therapy have been used separately for alleviation of pain and improvement of physical function in patients with knee osteoarthritis (KOA). However, no study has reported the effect of combination of these treatment modalities in the management of KOA. The aim of this study was to investigate the effect of end-range mobilization added to conservative therapy versus conservative therapy alone on decrease of pain and improvement of functional status in KOA.

Detailed Description

Knee osteoarthritis (KOA) is a musculoskeletal condition affecting older people. It is characterized by pain and loss of physical function, which has a negative impact on patients' quality of life. The different international guidelines recommend several non-invasive treatment modalities for the management of KOA. Conservative therapy including land-based exercises, aquatic exercises, Transcutaneous Electro Neuro Stimulation (TENS) therapy and balneotherapy has been reported positively in the management of patients with KOA (1, 2). Manual therapy is also a preferred treatment modality with the aim of alleviation of pain, improvement of joint mobility and therefore the physical condition (1, 2). Out of manual therapy techniques, end-range mobilization is a well applied treatment technique in the management of different musculoskeletal conditions (3). Till date, the effect of end-range mobilization has not been investigated so far in knee OA.

Therefore, the aim of this study was to investigate the effect of end-range mobilization added to conservative therapy versus conservative therapy alone on decrease of pain and improvement of functional status in KOA.

Study Timeline

• Study Start: 2020-02-12
• Primary Completion: 2020-02-12
• Study First Submitted: 2020-02-12
• Study First Submitted QC: 2020-02-12
• Study First Posted: 2020-02-17
• Study Completion: 2020-05-12
• Status Verified: 2020-10
• Last Update Submitted: 2020-10-31
• Last Update Posted: 2020-11-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• KOA according to the American College of Rheumatology
• categorization as End Of Range Problem based on Maitland's classification.
• at least half year existing and at least 3 pain scores measured with Visual Analogue Scale (VAS) during weight-bearing activities
• bilateral, moderate-to-severe symptomatic tibiofemoral knee OA with radiographic evidence
• at least 90 degree passive knee flexion range
• sufficient mental status

Exclusion Criteria

• acute inflammation of the knee
• intraarticular injections within the last 3 months
• total knee replacement in the opposite side
• class II. obesity (body mass index, BMI>35kg/m2)
• severe degenerative lumbar spine disease (e.g. spondylolisthesis)
• systemic inflammatory arthritic or neurological condition
• physiotherapy and other balneotherapy attendance within 6 months
• contraindication for conservative and manual therapy
• unstable heart condition
• complex regional pain syndrome

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control	Conservative therapy	Conservative therapy including aquatic exercises (5-times), land-based exercises (3-times), balneotherapy (5-times) and TENS therapy (3-times)
End-range mobilization	Conservative therapy	End-range mobilization applied 6 times for 2\*2 min in end-range of flexion and extension end-range of the tibiofemoral and patellofemoral joint beside the same conservative therapy, as used for the Control
End-range mobilization	Manual therapy	End-range mobilization applied 6 times for 2\*2 min in end-range of flexion and extension end-range of the tibiofemoral and patellofemoral joint beside the same conservative therapy, as used for the Control

Primary Outcome Measures

Name	Time	Method
general pain intensity	at the end of the 3-week rehabilitation	measuring of general pain intensity with Visual Analogue Scale

Secondary Outcome Measures

Name	Time	Method
pain intensity during getting up from a chair	at the end of the 3-week rehabilitation	measuring of pain intensity during getting up from a chair with Visual Analogue Scale
pain intensity during getting in car	at the end of the 3-week rehabilitation	measuring of pain intensity during getting in car with Visual Analogue Scale
pain intensity during turning while walking	at the end of the 3-week rehabilitation	measuring of pain intensity during turning while walking with Visual Analogue Scale
pain intensity during stair descending	at the end of the 3-week rehabilitation	measuring of pain intensity during stair descending with Visual Analogue Scale
Flexion and extension passive range of motion	at the end of the 3-week rehabilitation	Flexion and extension passive range of motion of the tibiofemoral joint
Quadriceps and hamstring muscles peak muscle force	at the end of the 3-week rehabilitation	Quadriceps and hamstring muscles peak muscle force of both knees
6-minute walk test	at the end of the 3-week rehabilitation	6-minute walk test measuring functional capacity
Timed Up and Go test	at the end of the 3-week rehabilitation	Timed Up and Go test measuring functional capacity

Trial Locations

Locations (1)

Zsigmondy Vilmos Spa and Balneological Hospital of Harkány; 🇭🇺 Harkány, Please Select, Hungary