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Clinical Trials/NCT04270253
NCT04270253
Completed
Not Applicable

End-range Mobilization Effecting Pain and Physical Function in the Management of Knee Osteoarthritis

University of Pecs1 site in 1 country30 target enrollmentFebruary 12, 2020

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Osteo Arthritis Knee
Sponsor
University of Pecs
Enrollment
30
Locations
1
Primary Endpoint
general pain intensity
Status
Completed
Last Updated
5 years ago

Overview

Brief Summary

Different manual therapy techniques and conservative therapy have been used separately for alleviation of pain and improvement of physical function in patients with knee osteoarthritis (KOA). However, no study has reported the effect of combination of these treatment modalities in the management of KOA. The aim of this study was to investigate the effect of end-range mobilization added to conservative therapy versus conservative therapy alone on decrease of pain and improvement of functional status in KOA.

Detailed Description

Knee osteoarthritis (KOA) is a musculoskeletal condition affecting older people. It is characterized by pain and loss of physical function, which has a negative impact on patients' quality of life. The different international guidelines recommend several non-invasive treatment modalities for the management of KOA. Conservative therapy including land-based exercises, aquatic exercises, Transcutaneous Electro Neuro Stimulation (TENS) therapy and balneotherapy has been reported positively in the management of patients with KOA (1, 2). Manual therapy is also a preferred treatment modality with the aim of alleviation of pain, improvement of joint mobility and therefore the physical condition (1, 2). Out of manual therapy techniques, end-range mobilization is a well applied treatment technique in the management of different musculoskeletal conditions (3). Till date, the effect of end-range mobilization has not been investigated so far in knee OA. Therefore, the aim of this study was to investigate the effect of end-range mobilization added to conservative therapy versus conservative therapy alone on decrease of pain and improvement of functional status in KOA.

Registry
clinicaltrials.gov
Start Date
February 12, 2020
End Date
May 12, 2020
Last Updated
5 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • KOA according to the American College of Rheumatology
  • categorization as End Of Range Problem based on Maitland's classification.
  • at least half year existing and at least 3 pain scores measured with Visual Analogue Scale (VAS) during weight-bearing activities
  • bilateral, moderate-to-severe symptomatic tibiofemoral knee OA with radiographic evidence
  • at least 90 degree passive knee flexion range
  • sufficient mental status

Exclusion Criteria

  • acute inflammation of the knee
  • intraarticular injections within the last 3 months
  • total knee replacement in the opposite side
  • class II. obesity (body mass index, BMI\>35kg/m2)
  • severe degenerative lumbar spine disease (e.g. spondylolisthesis)
  • systemic inflammatory arthritic or neurological condition
  • physiotherapy and other balneotherapy attendance within 6 months
  • contraindication for conservative and manual therapy
  • unstable heart condition
  • complex regional pain syndrome

Outcomes

Primary Outcomes

general pain intensity

Time Frame: at the end of the 3-week rehabilitation

measuring of general pain intensity with Visual Analogue Scale

Secondary Outcomes

  • pain intensity during getting up from a chair(at the end of the 3-week rehabilitation)
  • pain intensity during getting in car(at the end of the 3-week rehabilitation)
  • pain intensity during turning while walking(at the end of the 3-week rehabilitation)
  • pain intensity during stair descending(at the end of the 3-week rehabilitation)
  • Flexion and extension passive range of motion(at the end of the 3-week rehabilitation)
  • Quadriceps and hamstring muscles peak muscle force(at the end of the 3-week rehabilitation)
  • 6-minute walk test(at the end of the 3-week rehabilitation)
  • Timed Up and Go test(at the end of the 3-week rehabilitation)

Study Sites (1)

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