Effect of Peritoneal Lavage With Clindamycin-gentamicin Solution on Infection in Elective Surgery
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 102
- 主要终点
- Surgical site infection
研究概览
简要总结
Intrabdominal antibiotic irrigation will reduce wound and intrabdominal infection.
详细描述
A prospective, randomized study was performed between January and December 2010. Patient inclusion criteria were a diagnosis of colorectal neoplasms and plans to undergo an elective curative surgery. Patients were divided into 2 groups: Group 1 (intra-abdominal irrigation with normal saline) and Group 2 (intraperitoneal irrigation with a solution of 240 mg gentamicin and 600 mg clindamycin). The occurrence of wound infections and intra-abdominal abscesses were investigated. Following the anastomosis, a microbiological sample of the peritoneal surface was obtained (sample 1). A second sample was collected following an irrigation with normal saline (sample 2). Finally, the peritoneal cavity was irrigated with a gentamicin-clindamycin solution and a third sample was obtained (sample 3).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of colorectal neoplasms and plans to undergo an elective surgery with curative aims.
排除标准
- •preoperative diagnosis of chronic renal failure, because of the risk of nephrotoxicity associated with intraperitoneal gentamicin absorption
- •an anastomotic leak in the postoperative course
结局指标
主要结局
Surgical site infection
时间窗: 30 days
Intra-abdominal abscess and wound infection will be investigated during the first 30 days after colorectal surgery
次要结局
未报告次要终点