Study on the Effect of Fish Oil and Appetite

Early Phase 1

Completed

• Conditions: Obesity; Cachexia
• Interventions: Dietary Supplement: Fish oil

• Registration Number: NCT01692990
• Lead Sponsor: AAstrup

Brief Summary

20 normal-weight healthy subjects (10 males, 10 females) were in two periods given 10 of 0.5-mL capsules/day of fish oil and soybean oil for 3 weeks. In the end of each period they were given a standard breakfast and asked to report their appetite on visual analogue scales (VAS) immediately before and after the meal. The results were analyzed in accordance with the paired design under consideration of both supplement sequence and gender.

Detailed Description

In a randomized cross-over design, 20 normal-weight healthy subjects (10 males, 10 females) were given 10 of 0.5-mL capsules/day of fish oil and soybean oil for 3 weeks. In the end of each period they were given a standard breakfast and asked to report their appetite on visual analogue scales (VAS) immediately before and after the meal. The results were analyzed in accordance with the paired design under consideration of both supplement sequence and gender.

Study Timeline

• Study Start: 2011-10
• Primary Completion: 2011-11
• Study Completion: 2011-11
• Study First Submitted: 2012-05-14
• Status Verified: 2012-09
• Study First Submitted QC: 2012-09-25
• Study First Posted: 2012-09-26
• Last Update Submitted: 2012-11-09
• Last Update Posted: 2012-11-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Normal weight (18.5<BMI<25 kg/m2).
• Healthy.

Exclusion Criteria

• Subjects taking medication that could influence appetite.
• Subjects with special nutritional needs e.g. pregnant and lactating, seriously ill or old people.
• Subjects that had had fish oil-supplements for four weeks prior to the intervention period.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Fish oil	Fish oil	5 g/d in 10 capsules, providing 3.5 g of long-chain n-3 fatty acids
Soy bean oil	Fish oil	5 g/d in 10 capsules

Primary Outcome Measures

Name	Time	Method
Appetite and satiation	October 7th - November 25th 2011	Appetite and satiation were measured by visual analogue scales (VAS), which assessed satiation, hunger, fullness and desire to eat. Each scale was 100 mm in length with words anchored at each end, expressing the most positive and negative rating of each category.

Secondary Outcome Measures

Name	Time	Method
Weight change	October 7th - November 25th 2011	Body weight was measured on the same scale without shoes and wearing light clothing in the morning before breakfast.

Trial Locations

Locations (1)

Department of Human Nutrition; 🇩🇰 Frederiksberg, Denmark