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Changes in Cardiovascular Hemodynamics During Peritoneal Dialysis

Not Applicable
Terminated
Conditions
Peritoneal Dialysis
Registration Number
NCT00119990
Lead Sponsor
University of Aarhus
Brief Summary

During peritoneal dialysis, water is removed from the body. This sometimes occurs at rates of up to 500 ml/h. During shifts with dialysate with high glucose content, an increase in blood pressure has been described. The effect upon central hemodynamics is unknown. The researchers are investigating the effects of low and high glucose dialysate and icodextrin on cardiac output, stroke volume, pulse rate and blood pressure. The researchers have hypothesized that the effects seen are induced by vasopressin.

Detailed Description

Not available

Recruitment & Eligibility

Status
TERMINATED
Sex
All
Target Recruitment
15
Inclusion Criteria
  • Peritoneal dialysis patients
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Exclusion Criteria
  • Insulin dependent diabetes mellitus
  • AV-fistula, cardial arrhythmia persistence, or severe cardiac and lung disease
  • Recent infectious disease
  • Severe psychiatric disease
  • Hypersensitivity to icodextrin
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Study & Design

Study Type
INTERVENTIONAL
Study Design
CROSSOVER
Primary Outcome Measures
NameTimeMethod
Changes in cardiac hemodynamics. (Cardiac Output, stroke volume, pulse rate, blood pressure and total peripheral resistance)4 hours
Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Deparment of Renal Medicine, Skejby Hospital

🇩🇰

Aarhus, Denmark

Deparment of Renal Medicine, Skejby Hospital
🇩🇰Aarhus, Denmark
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