Clinical Characteristics and Analysis of Pituitary Complex and Rare Diseases
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 3,000
- 试验地点
- 1
- 主要终点
- Remission
研究概览
简要总结
The goal of this observational study is to systematically describe the clinical characteristics and outcomes of patients with pituitary complex and rare diseases at Peking Union Medical College Hospital. The main questions it aims to answer are:
- What are the influencing factors and rates of remission?
- What are the comorbidities associated with these diseases?
- What are the perioperative events, radiological findings, and pathological features?
Researchers will compare different patient groups to see if there are significant differences in these outcomes.
Participants will:
- Undergo detailed clinical evaluations.
- Provide medical history and data for analysis.
- Participate in follow-up assessments to monitor disease progression and treatment outcomes.
详细描述
The study aims to provide a comprehensive analysis of pituitary complex and rare diseases at Peking Union Medical College Hospital. By leveraging a large cohort, the research will explore various clinical characteristics and outcomes. Specifically, the study will examine influencing factors and rates of remission, the presence of comorbidities, and perioperative events. Additionally, it will evaluate radiological findings and pathological features to better understand these conditions. Through this detailed investigation, the study seeks to enhance knowledge and inform clinical practice regarding the management and prognosis of pituitary complex and rare diseases.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with rare sellar diseases including but not limited to pituitary adenomas (such as Thyrotropin-secreting pituitary adenomas, GH-secreting adenomas), craniopharyngiomas, Rathke's cleft cysts, sellar region germ cell tumors, cavernous sinus syndrome, and other diseases
- •Detailed medical history, including clinical symptoms, treatment plans and follow-up outcomes
排除标准
- •Incomplete medical records, especially missing key imaging diagnostic results
- •Patients with coexisting primary central nervous system diseases unrelated to sellar region diseases (such as severe traumatic brain injury)
- •Patients whose sellar region pathological diagnosis was changed or overturned during the follow-up period
结局指标
主要结局
Remission
时间窗: Postoperative one week and extends to the latest follow-up, estimated at up to 3 years
Hormonal normalization and free of pathologies
次要结局
- Disease Comorbidities(From patient admission to an evaluation period extending up to the latest follow-up, estimately up to 3 years)
- Postoperative complications(Postoperative one week and extends to the latest follow-up, estimated at up to 3 years)