Prospective Evaluation of Local Tumor Progression After Radiofrequency Ablation of Hepatocellular Carcinoma: Effectiveness of Immediate Second-Look Evaluation Using Pre-RFA MRI and Post-RFA CT Registration
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- HCC
- Sponsor
- Seoul National University Hospital
- Enrollment
- 77
- Locations
- 1
- Primary Endpoint
- Local tumor progression (LTP)
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Magnetic resonance imaging (MRI) has been widely used for small liver lesion detection and characterization. In patients who undergo RFA, MRI is often performed before RFA, whereas immediate technical success is usually assessed by CT. Conventional visual assessment of two modalities may be more challenging than being anticipated, because acquisition position, respiration, and spatial resolution differ between the two. Therefore, the study purpose is to evaluate the results of software-assisted ablative margin assessment using registration of different pre-and post-RFA modalities compared with the conventional method of side-by-side MRI-CT comparison in patients with HCCs.
Investigators
Jeong Min Lee
Professor
Seoul National University Hospital
Eligibility Criteria
Inclusion Criteria
- •patients (≥ 18 years) who were referred to our radiology department for liver tumor RFA
- •patients who had liver MR images of sufficient quality for pre-RFA evaluation within 30 days before RFA
- •patients with 1-3 tumors (\<5 cm)
Exclusion Criteria
- •Child-Pugh class C
- •any uncorrected coagulopathy
- •hypersensitivity to iodine or other reasons that prevented the performance of post-RFA contrast-enhanced CT
Outcomes
Primary Outcomes
Local tumor progression (LTP)
Time Frame: 60 months
5-year-LTP rate in HCC between sufficient and insufficient ablative margin groups (according to visual assessment and registration software-assisted assessment)
Secondary Outcomes
- technique efficacy(1 month after RFA)
- immediate technical success on visual assessment(1 day after RFA)
- immediate technical success on registration-software assessment(1 day after RFA)