Intradialytic Aerobic Exercise in CKD Patient

Not Applicable

Completed

• Conditions: Chronic Kidney Diseases
• Interventions: Behavioral: Aerobic Exercise

• Registration Number: NCT06137937
• Lead Sponsor: Universitas Padjadjaran

Brief Summary

Intradialytic aerobic exercise is not effective in increasing hemodialysis adequacy but is effective in improving physical performance in twice-weekly hemodialysis patients.

Detailed Description

Uremic myopathy occurs in 60-75% of Chronic Kidney Disease (CKD) patients undergoing hemodialysis, which causes a decrease in muscle strength and physical performance. Increasing dialysis adequacy is beneficial in reducing the impact of uremia on muscles. Intradialytic aerobic exercise in thrice-weekly hemodialysis patients has improved dialysis adequacy and physical performance. This study aims to determine the effect of intradialytic aerobic exercise on improving dialysis adequacy and physical performance in twice-weekly hemodialysis patients.

Study Timeline

• Study Start: 2023-11-01
• Study First Submitted: 2023-11-13
• Study First Submitted QC: 2023-11-13
• Study First Posted: 2023-11-18
• Primary Completion: 2023-12-27
• Study Completion: 2023-12-27
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-19
• Last Update Posted: 2025-03-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• End Stage Renal Disease Patient stage 5 with Glomerular Filtration Rate <15mL/minute/1.73m2 aged 25-54 years undergoing hemodialysis two times per week for three months to five years
• Hemoglobin levels > 8mg/dl
• Mini-Mental State Examination (MMSE) score of ≥24
• Hamilton Depression Rating Scale (HDRS) score <25

Exclusion Criteria

• Received aerobic exercise in the last 3 months
• History of hospitalization in the last 3 months
• Access for hemodialysis circulation via the femoral vein.
• IMT <18,5 (underweight) dan ≥35 (obese class II)
• Non-stable cardiovascular disease, uncontrolled glucose, acute infection disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Interventional Group	Aerobic Exercise	subjects in the treatment group underwent routine hemodialysis by committing to an intradialysis aerobic exercise program

Primary Outcome Measures

Name	Time	Method
Kt/V	eight weeks	Dialysis adequacy (Kt/V) and physical performance test with a Short Physical Performance Battery (SPPB) were evaluated before and after the intervention

Trial Locations

Locations (1)

Al Ihsan Hospital; 🇮🇩 Bandung, West Java, Indonesia