A Study Of PF-05280586 (Rituximab-Pfizer) Or MabThera® (Rituximab-EU) For The First-Line Treatment Of Patients With CD20-Positive, Low Tumor Burden, Follicular Lymphoma (REFLECTIONS B328-06)
- Conditions
- Follicular Lymphoma
- Interventions
- Biological: PF-05280586Biological: MabThera®
- Registration Number
- NCT02213263
- Lead Sponsor
- Pfizer
- Brief Summary
This study will compare the safety and effectiveness of PF-05280586 versus rituximab-EU in patients with CD20-positive, low tumor burden follicular lymphoma. The primary hypothesis to be tested in this study is that the effectiveness of PF-05280586, as measured by the Overall Response Rate, is similar to that of rituximab-EU.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 394
- Confirmed diagnosis of low tumor burden, CD20-positive follicular lymphoma
- Ann Arbor Stage II, III, or IV
- Not a candidate for treatment with rituximab as a single-agent
- Evidence of transformation to a high grade or diffuse large B-cell lymphoma
- Any previous systemic therapy for B-cell NHL, including chemotherapy, immunotherapy, or steroids
- Any prior treatment with rituximab
- Active, uncontrolled infection
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description PF-05280586 PF-05280586 - MabThera® MabThera® -
- Primary Outcome Measures
Name Time Method Overall Response Rate (ORR): Percentage of Participants With Overall Response (OR) at Week 26 Week 26 ORR was defined as the percentage of participants who achieved complete response (CR) or partial response (PR) in accordance with the revised response criteria for malignant lymphoma (Cheson 2007). CR was defined as disappearance of all evidence of disease. PR was defined as regression of measureable disease and no new sites.
- Secondary Outcome Measures
Name Time Method Number of Participants With Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs) Baseline up to Week 52 An AE was any untoward medical occurrence in participants who received study drug without regard to possibility of causal relationship. SAE was an AE resulting in any of the following outcomes or deemed significant for any other reason: death; initial or prolonged inpatient hospitalization; life-threatening experience (immediate risk of dying); persistent or significant disability/incapacity; congenital anomaly. Treatment-emergent were events after first dose of study drug that were absent before treatment or that worsened relative to pretreatment state. AEs included both serious and non-serious.
Number of Participants With Clinically Significant Laboratory Abnormalities Baseline up to Week 52 Criteria for clinically significant laboratory abnormalities included total bilirubin (TB) less than (\<) 2\*upper limit of normal (ULN), alanine aminotransferase (ALT)\<3\*ULN; TB\<2\*ULN, ALT more than (\>) 3 equal to (=) \*ULN; TB\<2\*ULN, aspartate aminotransferase (AST)\<3\*ULN; TB\<2\*ULN, AST\>=3\*ULN. Data for only those categories are reported for which at least one participant had clinically significant laboratory abnormality.
Number of Participants With Grade 3 or Higher Treatment-Related Treatment-Emergent Adverse Events (AEs) as Graded by National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version 4.03 Baseline up to Week 52 Treatment-related AE was any untoward medical occurrence attributed to study drug in a participant who received study drug. Grade 1=Mild, asymptomatic or mild symptoms, Grade 2=Moderate; minimal, local or noninvasive intervention indicated; Grade 3 (Severe) events=unacceptable or intolerable events, significantly interrupting usual daily activity, require systemic drug therapy/other treatment. Grade 4 (Life-threatening) events caused participant to be in imminent danger of death. Grade 5 = death. Treatment-emergent were events after first dose of study drug that were absent before treatment or that worsened relative to pretreatment state.
Percentage of Participants With Complete Remission (CR) at Week 26 Week 26 Complete Remission (CR) was defined as disappearance of all evidence of disease. CR was assessed by central review based on scans done at Week 26.
Duration of Response (DOR) From date of first documentation of overall response to first documentation of PD or to death due to any cause in absence of PD or up to Week 52 DOR was defined as the time (in months) from date of the first documentation of overall response (CR or PR) to the first documentation of progressive disease (PD) based on central review or to death due to any cause in the absence of documented PD. CR was defined as disappearance of all evidence of disease. PR was defined as regression of measureable disease and no new sites. PD was defined as any new lesion or increase by \>=50% of previously involved sites from nadir. DOR was calculated using Kaplan-Meier method.
Time to Treatment Failure (TTF) From randomization until disease progression, death or permanent discontinuation from treatment/study due to any reason, or up to Week 52 TTF was defined as the time (in months) from date of randomization to first progression of disease based on central review, death due to any cause, or permanent discontinuation from treatment, or discontinuation from study for any reason, whichever came first. Progression was defined as any new lesion or increase by greater than or equal to (\>=) 50% of previously involved sites from nadir. TTF was calculated using Kaplan-Meier method.
Progression-Free Survival (PFS) From randomization until disease progression or death due to any cause or up to Week 52 PFS was defined as the time (in months) from date of randomization to first progression of disease (PD) based on central review or death due to any cause in the absence of documented PD. PD was defined as any new lesion or increase by \>=50% of previously involved sites from nadir. PFS was calculated using Kaplan-Meier method.
Overall Survival From randomization until death due to any cause or up to Week 52 Overall survival was defined as the time (in months) from date of randomization to death due to any cause. For participants who were alive, overall survival was censored at the last contact. Overall survival was calculated using Kaplan-Meier method.
Number of Participants With Treatment Related Treatment-Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs) Baseline up to Week 52 Treatment-related AE was any untoward medical occurrence attributed to study drug in a participant who received study drug. SAE was an AE resulting in any of the following outcomes or deemed significant for any other reason: death; initial or prolonged inpatient hospitalization; life-threatening experience (immediate risk of dying); persistent or significant disability/incapacity; congenital anomaly. Treatment-emergent were events after first dose of study drug that were absent before treatment or that worsened relative to pretreatment state. Relatedness to treatment was assessed by investigator. AEs included both serious and non-serious AEs.
Number of Participants With Grade 3 or Higher Treatment-Emergent Adverse Events (AEs) as Graded by National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version 4.03 Baseline up to Week 52 An AE was any untoward medical occurrence in participant who received study drug without regard to possibility of causal relationship. Grade 1=Mild, asymptomatic or mild symptoms, Grade 2=Moderate; minimal, local or noninvasive intervention indicated, Grade 3 (Severe) events=unacceptable or intolerable events, significantly interrupting usual daily activity, require systemic drug therapy/other treatment. Grade 4 (Life threatening) events caused participant to be in imminent danger of death. Grade 5 = death. Treatment-emergent were events after first dose of study drug that were absent before treatment or that worsened relative to pretreatment state.
Maximum Observed Serum Concentration (Cmax) of PF-05280586 and Rituximab-EU Predose (within 4 hours prior to start of infusion) on Days 1, 8, 15 and 22; within 15 minutes prior to end of infusion on Days 1 and 22 Cluster of Differentiation (CD) 19-Positive B-Cell Counts Baseline, Week 2, 3, 4, 5, 13, 26, 39, 52 Number of Participants With Positive Anti-Drug Antibodies (ADAs) and Neutralizing Antibodies (NAbs) Baseline up to Week 52 Human serum ADA samples were analyzed for the presence or absence of anti-rituximab antibodies or anti-PF-05280586 antibodies using the validated drug-specific assay with a tiered approach using screening, confirmation and titer/quantitation. Human NAb serum samples testing ADA positive were analyzed for the presence or absence of neutralizing anti-rituximab antibody and neutralizing anti-PF-05280586 antibody using the validated drug-specific assay with a tiered approach using screening, confirmation and titer/quantitation. Participants with their ADA titer \>= 1.88 were considered to be ADA positive. Only participants with a positive ADA result were further tested for NAb.
Minimum Observed (Trough) Serum Concentration (Ctrough) of PF-05280586 and Rituximab-EU Predose (within 4 hours prior to the start of dosing) on Day 1, 8, 15, and 22 Number of Participants Reporting Immune-Based Adverse Effects Baseline up to Week 52 Immune-based adverse effects included infusion related reaction (IRR), adverse events which fulfill Sampson's criteria, and adverse events which belong to the Standardized Medical Dictionary for Regulatory Activities (MedDRA) Queries (SMQs) anaphylaxis or hypersensitivity reactions. Potential allergic and anaphylactic reactions were identified programmatically based on the criteria of Sampson et al, (2006).
Trial Locations
- Locations (376)
PET/CT facility: Grand Hopital de Charleroi (GHdC) - site Notre-Dame
🇧🇪Charleroi, Belgium
Pharmacy Department, Centre Hospitalier De Jolimont - Lobbes
🇧🇪La Louviere (Haine-Saint Paul), Belgium
Unita di Ricerca Clinica
🇮🇹Monza, MB, Italy
Inje University Busan Paik Hospital
🇰🇷Busan, Korea, Republic of
Hiperdia Ritmului
🇷🇴Bucuresti, Romania
Los Angeles Hematology Oncology Medical Group
🇺🇸Los Angeles, California, United States
Rocky Mountain Cancer Center Pueblo
🇺🇸Pueblo, Colorado, United States
Comprehensive Cancer Centers of Nevada
🇺🇸Las Vegas, Nevada, United States
Millennium Oncology
🇺🇸The Woodlands, Texas, United States
Central de Misturas Intravenosas do Hospital de Clinicas de Porto Alegre
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Hospital das Clinicas Universidade Federal de Minas Gerais
🇧🇷Belo Horizonte, Minas Gerais, Brazil
Hospital de Clinicas de Porto Alegre
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Servico de Radiologia do Hospital de Clinicas de Porto Alegre
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Pharmacy Department, CHU Ambroise Pare
🇧🇪Mons, Belgium
University Hospital Centre "Sestre Milosrdnice"
🇭🇷Zagreb, Croatia
National Hospital Organization Matsumoto Medical Center
🇯🇵Nagano, Japan
Spandan PET-CT Unit
🇮🇳Kolkata, WEST Bengal, India
Saint Francis Medical Center, Saint Francis Cancer Treatment Center
🇺🇸Hastings, Nebraska, United States
University Hospital Center Zagreb, Department of Pathology and Cytology
🇭🇷Zagreb, Croatia
Willamette Valley Cancer Institute and Research Center
🇺🇸Eugene, Oregon, United States
SI 'Republican Research and Practice Centre of Oncology and Medical Radiology n.a. N.N. Alexandrov'
🇧🇾Lesnoy, Minsk Region, Belarus
Grand Hopital de Charleroi-Site Notre-Dame
🇧🇪Charleroi, Belgium
Centre Hospitalier de Jolimont - Lobbes
🇧🇪La Louviere (Haine-Saint-Paul), Belgium
University Hospital Center Zagreb, Department of Nuclear Medicine and Radiation Protection
🇭🇷Zagreb, Croatia
General Hospital of Athens 'Laiko'
🇬🇷Athens, Greece
"ATTIKON'' Gen. Univ. Hosp.
🇬🇷Chaidari, Athens, Greece
East Nagoya Imaging Diagnosis Center
🇯🇵Nagoya, Aichi, Japan
Akita University Hospital
🇯🇵Akita City, Akita, Japan
SI Republican Research and Practice Centre of oncology and medical radiology n.a N.N Alexandrov
🇧🇾Republic Of Belarus, Belarus
"LTD ""M. Zodelava's Hematology Centre"""
🇬🇪Tbilisi, Georgia
Dolnoslaskie Centrum Transplantacji Komorkowych z Krajowym Bankiem Dawcow Szpiku
🇵🇱Wroclaw, Poland
Krankenhaus der Barmherzigen Schwestern Linz
🇦🇹Linz, Austria
Gen. Hosp. of Athens "Evangelismos-Eye Hosp.-Polikliniki"
🇬🇷Athens, Greece
Vely Grupo Medico Quirurgico, S.A. de C.V.
🇲🇽Cuautitlan Izacalli, Estado DE Mexico, Mexico
Oaxaca Site Management Organization S.C.
🇲🇽Oaxaca, Mexico
Clinica de Hematologie-Institutul Oncologic, Prof. Dr. Ion Chiricuta
🇷🇴Cluj-Napoca, Romania
FSBI "Russian Research Centre of Radiology and Surgical Technologies named after academician
🇷🇺Saint-Petersburg, Pesochniy, Russian Federation
State Budgetary Healthcare Institution "Republican Clinical Oncology Dispensary of the Ministry
🇷🇺Ufa, Republic Bashkortostan, Russian Federation
N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences
🇷🇺Saint-Petersburg, Russian Federation
National Cancer Institute
🇺🇦Kyiv, Ukraine
Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi
🇹🇷Gaziantep, Turkey
Erciyes Universitesi Tip Fakultesi Nukleer Tip Laboratuvari
🇹🇷Kayseri, Turkey
Erciyes Universitesi Tip Fakultesi
🇹🇷Kayseri, Turkey
N.R.S Medical College and Hospital
🇮🇳Kolkata, WEST Bengal, India
LTD "Research Institute of Clinical Medicine"
🇬🇪Tbilisi, Georgia
HealthCare Global Enterprises Limited
🇮🇳Bangalore, Karnataka, India
Rajiv Gandhi Cancer Institute & Research Center (RGCIRC)
🇮🇳New Delhi, India
Showa University Northern Yokohama Hospital
🇯🇵Yokohama-shi, Kanagawa-ken, Japan
Kochi Medical School Hospital
🇯🇵Okocho, Nankoku, Kochi, Japan
Hospital Infantil Teleton de Oncologia
🇲🇽Queretaro, Mexico
Hospital San Jose Norte
🇲🇽Queretaro, Mexico
Affidea Fundeni
🇷🇴Bucuresti, Romania
Department of Radiology, Curie Manavata Cancer Centre
🇮🇳Nashik, Maharashtra, India
Apollo Speciality Hospital
🇮🇳Chennai, Tamilnadu, India
Vijaya Diagnostic Centre
🇮🇳Hyderabad, Telangana, India
Unidade Local de Saude de Matosinhos E.P.E. - Hospital Pedro Hispano S.A.
🇵🇹Matosinhos, Porto, Portugal
University General Hospital of Patras
🇬🇷Patras, Greece
Clinica Ematologica - A.O.U. Ospedali Riuniti di Ancona
🇮🇹Torrette Ancona, Palermo, Italy
Fukuoka Wajiro PET Diagnostic Imaging Clinic
🇯🇵Fukuoka, Japan
Doctors Center Radiology
🇱🇧Beirut, Lebanon
Mount Lebanon Hospital
🇱🇧Beirut, Lebanon
Department of Radiology
🇮🇳Chennai, Tamilnadu, India
Hospital Angeles Puebla
🇲🇽Puebla, Mexico
Euromedic Wroclawskie Centrum Medyczne III
🇵🇱Wroclaw, Poland
Apteka Dolnoslaskiego Centrum Transplantacji Komorkowych z Krajowym Bankiem Dawcow Szpiku
🇵🇱Wroclaw, Poland
CIMC
🇵🇹Porto, Portugal
Policlinica de Diagnostic Rapid, Hematologie
🇷🇴Brasov, Romania
Affidea Romania SRL
🇷🇴Bucuresti, Romania
Institutul Oncologic Prof. Dr. Ion Chiricuta, Laborator Radiologie si Imagistica Medicala
🇷🇴Cluj-Napoca, Romania
A.Tsyb Medical Radiological Research Centre -
🇷🇺Obninsk, Kaluga Region, Russian Federation
Phylasis Clinicas Research S. de R.L. de C.V.
🇲🇽Cuautitlan Izcalli, Estado DE Mexico, Mexico
Instituto Nacional de Enfermedades Neoplasicas
🇵🇪Surquillo, Lima, Peru
St. Luke's Medical Center
🇵🇭Quezon City, Philippines
Klinika Nowotworow Ukladu Chlonnego Centrum Onkologii - Instytut im. M. Sklodowskiej-Curie
🇵🇱Warszawa, Poland
Euromedic Wroclawskie Centrum Medyczne II
🇵🇱Wroclaw, Poland
Instituto Portugues de Oncologia do Porto Francisco Gentil E.P.E
🇵🇹Porto, Portugal
Policlinica de Diagnostic Rapid SA
🇷🇴Brasov, Romania
Cancerologia de Queretaro S.C.
🇲🇽Queretaro, Mexico
Modern Radiology, PSC
🇵🇷Coto Laurel, Puerto Rico
Spitalul Clinic Coltea, Clinica de Hematologie
🇷🇴Bucuresti, Romania
Institutul Oncologic Prof. Dr. Ion Chiricuta, Sectia Oncologie Medicala
🇷🇴Cluj-Napoca, Romania
Non-state healthcare institution "Road Clinical Hospital of Joint Stock Company "Russian Railways"
🇷🇺Saint-Petersurg, Russian Federation
Hacettepe Universitesi Tip Fakultesi Onkoloji Hastanesi
🇹🇷Ankara, Turkey
LLC "VitaMed"
🇷🇺Moscow, Russian Federation
Hospital Parc Tauli
🇪🇸Sabadell, Barcelona, Spain
State Healthcare Institution Republican Oncology Dispensary
🇷🇺Saransk, Mordovian Republic, Russian Federation
LLC MC "MRT-Diagnostika"
🇷🇺Nizhniy Novgorod, Nizhniy Novgorod Region, Russian Federation
FSBI "Russian Research Centre of Radiology and Surgical Technologies" of MoH of RF
🇷🇺Pesochniy Town, Saint-petersburg, Russian Federation
FSBI 'National Medical Oncology Research Centre n.a. N.N.Petrov'
🇷🇺Saint-Petersburg, Pos.pesochny, Russian Federation
Private medical institution "Euromedservice"
🇷🇺Pushkin, Saint Petersburg, Russian Federation
"State Budget Healthcare Institution ""Chelyabinsk Regional Clinical Center of Oncology
🇷🇺Chelyabinsk, Russian Federation
Dr. Berezin Medical Institute
🇷🇺Saint-Petersburg, Russian Federation
Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi
🇹🇷Istanbul, Turkey
Erciyes Universitesi Tip Fakultesi Radyoloji Laboratuvari
🇹🇷Kayseri, Turkey
Inonu Universitesi Tip Fakultesi Turgut Ozal Tip Merkezi
🇹🇷Malatya, Turkey
"MedX-Ray International Group" LLC
🇺🇦Obukhiv, KYIV Region, Ukraine
"SBHI of NNR ""Nizhniy Novgorod Regional Clinical Hospital n.a. N.A. Semashko"""
🇷🇺Nizhniy Novgorod, Nizhniy Novgorod Region, Russian Federation
FSBI "Russian Research Centre of Radiology and Surgical Technologies"
🇷🇺Saint-Petersburg, Pesochniy TOWN, Russian Federation
Federal State-Financed Institution 'North-Caucasian Research and Clinical Center'
🇷🇺Lermontov, Stavropol Region, Russian Federation
N.P. Bechtereva Institute of Human Brain of the Russian Academy of Sciences
🇷🇺Saint-Petersburg, Russian Federation
Cardiology Unit,Department of Medicine, Faculty of Medicine, Ramathibodi Hospital,
🇹🇭Bangkok, Thailand
Ultramar Tibbi Gorunteleme Merkezi
🇹🇷Ankara, Turkey
Ege Universitesi Tip Fakultesi Ic Hastaliklari Anabilim Dali
🇹🇷Izmir, Turkey
Ramsay Diagnostics
🇷🇺Moscow, Russian Federation
FSBI 'Russian Research Centre of Radiology and Surgical Technologies
🇷🇺Saint-Petersburg, Pesochniy TOWN, Russian Federation
Branch office of LLC 'PET-Technology' at Ufa city
🇷🇺Ufa, Republic Bashkortostan, Russian Federation
Apotheke, Spital STS AG
🇨🇭Thun, Switzerland
Podilskyy Regional Oncology Center, Chemotherapy Department
🇺🇦Vinnytsia, Ukraine
FSBSI 'N.N.Blokhin Russian Cancer Research Center' of MoH of RF
🇷🇺Moscow, Russian Federation
"Mediks-rey International Group" LLC
🇺🇦Obukhiv District, KYIV Region, Ukraine
Municipal Establishment 'Zaporizhzhia Regional Clinical Oncology Dispensary'
🇺🇦Zaporizhzhia, Ukraine
LLC "Diaservis"
🇺🇦Zaporizhzhia, Ukraine
Az Ospedaliera Santa Maria
🇮🇹Terni, PG, Italy
Radiologia
🇮🇹Reggio Emilia, Reggio, Italy
"Dipartimento di Biotecnologie Cellulari ed Ematologia, Universita ""Sapienza""
🇮🇹Rome, Rome Rm, Italy
SC Ematologia, Fondazione IRCCS Ist Nazionale dei Tumori
🇮🇹Milano, Italy
U.O. Ematologia Universitaria - Dip. Di Oncologia dei Trapianti - AOU Pisana
🇮🇹Pisa, Italy
Cobalt Diagnostic Imaging
🇬🇧Cheltenham, Glos., United Kingdom
Royal United Hospitals Bath NHS Foundation Trust
🇬🇧Bath, United Kingdom
Compassionate Care Research Group, Inc., at Compassionate Cancer Care Medical Group, Inc.
🇺🇸Riverside, California, United States
The Oncology Institute of Hope and Innovation
🇺🇸Whittier, California, United States
Global Cancer Research Institute (GCRI), Inc
🇺🇸Gilroy, California, United States
Global Cancer Research Institute, Inc.
🇺🇸San Jose, California, United States
Innovative Clinical Research Institute (ICRI)
🇺🇸Whittier, California, United States
Rocky Mountain Cancer Center-Lakewood (Laboratory)
🇺🇸Lakewood, Colorado, United States
Rocky Mountain Cancer Centers (RMCC) - Lakewood - St Anthony
🇺🇸Lakewood, Colorado, United States
Pacific Cancer Medical Center, Inc.
🇺🇸Anaheim, California, United States
O'Connor Hospital
🇺🇸San Jose, California, United States
Torrance Memorial Medical Center
🇺🇸Torrance, California, United States
Cancer Center Of Kansas
🇺🇸Winfield, Kansas, United States
PET Imaging of San Jose (Imaging Only)
🇺🇸San Jose, California, United States
Rocky Mountain Cancer Centers
🇺🇸Lone Tree, Colorado, United States
Holy Cross Hospital Resource Center
🇺🇸Silver Spring, Maryland, United States
Cancer Center of Kansas
🇺🇸Wichita, Kansas, United States
Saint Agnes Hospital
🇺🇸Baltimore, Maryland, United States
Kepler Universitaetsklinikum GmbH
🇦🇹Linz, Austria
San Antonio Military Medical Center- Department of Pharmacy
🇺🇸Fort Sam Houston, Texas, United States
The University of Kansas Cancer Center
🇺🇸Lee's Summit, Missouri, United States
Toledo Clinic Cancer Center - Toledo
🇺🇸Toledo, Ohio, United States
PET/CT facility Seton Imaging Center
🇺🇸Baltimore, Maryland, United States
Toledo Clinic Cancer Center - Maumee
🇺🇸Maumee, Ohio, United States
Saint Francis Medical Center
🇺🇸Grand Island, Nebraska, United States
US Oncology Investigational Products Center (IPC)
🇺🇸Irving, Texas, United States
Texas Oncology - Longview Cancer Center
🇺🇸Longview, Texas, United States
Brody School of Medicine at East Carolina University
🇺🇸Greenville, North Carolina, United States
Healthcare Institution "Brest Regional Oncologic Dispensary"
🇧🇾Brest, Belarus
Vidant Medical Center Pharmacy
🇺🇸Greenville, North Carolina, United States
Maryland Oncology Hematology, P.A.
🇺🇸Wheaton, Maryland, United States
Toledo Clinic, Inc.
🇺🇸Toledo, Ohio, United States
San Antonio Military Medical Center- Department of Radiology
🇺🇸Fort Sam Houston, Texas, United States
University of Tennessee Medical Center
🇺🇸Knoxville, Tennessee, United States
Texas Oncology-Tyler
🇺🇸Tyler, Texas, United States
Yakima Valley Memorial Hospital/North Star Lodge Cancer Center
🇺🇸Yakima, Washington, United States
Healthcare Institution 'Minsk City Clinical Oncology Dispensary'
🇧🇾Minsk, Belarus
Hopital Erasme
🇧🇪Brussels, Belgium
Pharmacy Department: Grand Hopital de Charleroi (GHdC) - site Notre-Dame
🇧🇪Charleroi, Belgium
Clinica Multimagem
🇧🇷Goiania, GO, Brazil
Hospital de Clinicas de Porto Alegre - Centro de Pesquisa Clinica
🇧🇷Porto Alegre, RIO Grande DO SUL, Brazil
Unidade Funcional Apoio Diagnostico e terapeutica por Imagem do HC/UFMG - CT Scan
🇧🇷Belo Horizonte, MG, Brazil
Hospital e Maternidade Madre Theodora LTDA
🇧🇷Campinas, SP, Brazil
CENNI Oncologia
🇧🇷Campinas, SP, Brazil
Unidade de Quimioterapia
🇧🇷Jaú, SAO Paulo, Brazil
Fundacao do ABC - FMABC/ Faculdade de Medicina ABC ( CEPHO - Centro de Estudos e Pesquisas de
🇧🇷Santo Andre, SP, Brazil
Casa de Saude Santa Marcelina (Centro de Pesquisa Santa Marcelina)
🇧🇷Sao Paulo, SP, Brazil
University Hospital Center Zagreb, Department of Radiology
🇭🇷Zagreb, Croatia
Charite - Universitaetsmedizin Berlin, Campus Virchow-Klinikum
🇩🇪Berlin, Germany
University Hospital Centre Zagreb
🇭🇷Zagreb, Croatia
Charite - Universitatsmedizin Berlin - Campus Benjamin Franklin
🇩🇪Berlin, Germany
CHU Marseille Hopital de La Conception
🇫🇷Marseille, Marseille Cedex 05, France
High Technology Medical Center, University Clinic
🇬🇪Tbilisi, Georgia
DokuSan Gesellschaft fuer Medizinische Studien mbH & Co. KG
🇩🇪Herne, Germany
Charite - Universitatsmedizin Berlin
🇩🇪Berlin, Germany
Universitaetsklinikum Essen (AoeR)
🇩🇪Essen, Germany
Gemeinschaftspraxis fuer Diagnostische Radiologie und Nuklearmedizin
🇩🇪Mutlangen, Germany
Stauferklinikum Schwaebisch Gmuend, Apotheke
🇩🇪Mutlangen, Germany
EVK Eickel
🇩🇪Herne, Germany
Kliniken Ostalb, Stauferklinikum Schwaebisch Gmuend, Zentrum fuer Innere Medizin
🇩🇪Mutlangen, Germany
Praxis im Koeln Triangle
🇩🇪Koeln, Germany
Gen. Hosp. of Athens "Evangelismos - Eye Hosp.- Polikliniki"
🇬🇷Athens, Greece
General Hospital of Athens "Evangelismos - Eye Hosp. - Polikliniki"
🇬🇷Athens, Greece
Gen. Hosp. of Athens "Evangelismos-Eye Hosp. - Polikliniki"
🇬🇷Athens, Greece
"""ATTIKON"" Gen. Univ. Hosp"
🇬🇷Athens, Greece
Bioiatriki S.A.
🇬🇷Athens, Greece
Bioiatriki
🇬🇷Athens, Greece
Magnitiki Patron
🇬🇷Patras, Greece
Super Scan Imaging Centre
🇮🇳Surat, Gujarat, India
Kasturba Medical College and Hospital
🇮🇳Manipal, Karnataka, India
Zircon- BIC Imaging Centre
🇮🇳Surat, Gujarat, India
Mangalore Institute of Oncology
🇮🇳Mangalore, Karanataka, India
Chiba Cancer Center
🇯🇵Chiba-shi, Chiba, Japan
Jehangir Clinical Development Centre Pvt. Ltd.
🇮🇳Pune, Maharashtra, India
Curie Manavata Cancer Centre
🇮🇳Nashik, Maharashtra, India
Nagoya Daini Red Cross Hospital
🇯🇵Nagoya, Aichi, Japan
National Hospital Organization Kyushu Medical Center
🇯🇵Fukuoka-shi, Fukuoka, Japan
National Hospital Organization Kanazawa Medical Center
🇯🇵Kanazawa, Ishikawa, Japan
Nagano Red Cross Hospital
🇯🇵Nagano-shi, Nagano, Japan
National Hospital Organization Nagasaki Medical Center
🇯🇵Omura, Nagasaki, Japan
Osaka City University Hospital
🇯🇵Osaka-City, Osaka, Japan
Policlinico Universitario Campus Bio- Medico-U.O.C. di Ematologia Trapianto Cellule Staminali
🇮🇹Roma, Italy
R.K. Birla Cancer Center, Sawai Man Singh Hospital
🇮🇳Jaipur, Rajasthan, India
National Hospital Organization Tokyo Medical Center
🇯🇵Meguro-Ku, Tokyo, Japan
U.O. di Ematologia e CTMO - Istituti Ospedalieri di Cremona
🇮🇹Cremona, CR, Italy
Medicina nucleare
🇮🇹Reggio Emilia, Reggio, Italy
Kobe City Medical Center General Hospital
🇯🇵Kobe-City, Hyogo, Japan
Kanazawa Advanced Medical Center
🇯🇵Kanazawa, Ishikawa, Japan
Uozumi Clinic
🇯🇵Kumamoto-shi, Kumamoto-ken, Japan
Padiglione 1, Torre delle medicine, 6 piano
🇮🇹Parma, Italy
Ematologia e Centro Trapianti - AZ Osp. Ospedali Riuniti Marche Nord (AORMN) - Presidio S. Salvatore
🇮🇹Pesaro, Italy
National Hospital Organization Kyushu Cancer Center
🇯🇵Fukuoka-Shi, Fukuoka, Japan
Sendai Kousei Hospital
🇯🇵Sendai-shi, Miyagi, Japan
National Hospital Organization Sendai Medical Center
🇯🇵Sendai-shi, Miyagi, Japan
Aizawa Hospital
🇯🇵Matsumoto-shi, Nagano, Japan
Hanwa Dai 2 Senboku Hospital
🇯🇵Naka-ku Sakai, Osaka, Japan
Tokushima University Hospital
🇯🇵Tokushima-Shi, Tokushima, Japan
National Hospital Organization Disaster Medical Center
🇯🇵Tachikawa, Tokyo, Japan
Showa University Hospital
🇯🇵Shinagawa-ku, Tokyo, Japan
Musashimurayama Hospital
🇯🇵Tokyo, Japan
Hammoud Hospital, University Medical Center
🇱🇧Saida, Southern Governate, Lebanon
Middle East Institute Of Health
🇱🇧El Metn, Lebanon
Isos Pharmacorp, S.A. de C.V.
🇲🇽Mexico City, Distrito Federal, Mexico
Grupo Medico Camino S.C.
🇲🇽Mexico City, Distrito Federal, Mexico
Cirurgia y Ginecobstetricia de Oaxaca, S.A de C.V.
🇲🇽Oaxaca, Mexico
Resocentro
🇵🇪Lima, Peru
Hospital do Meixoeiro Complejo Hospitalario Universitario de Vigo
🇪🇸Vigo, Pontevedra, Spain
Onkologiezentrum Thun-Berner Oberland Spital Sts Ag
🇨🇭Thun, Switzerland
UniversitaetsSpital Zuerich
🇨🇭Zuerich, Switzerland
Hospital Universitario Sanitas La Zarzuela
🇪🇸Aravaca, Madrid, Spain
University of Philippines Manila-Philippine General Hospital
🇵🇭Manila, Metro Manila, Philippines
Hospital de Braga
🇵🇹Braga, Portugal
Euromedic Wroclawskie Centrum Medyczne I
🇵🇱Wroclaw, Poland
Dr. Campos Costa Clinic
🇵🇹Porto, Portugal
Hospital CUF Descobertas
🇵🇹Lisboa, Portugal
Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
🇵🇹Vila Nova de Gaia, Portugal
Ad-Vance Medical Research, LLC
🇵🇷Ponce, Puerto Rico
Centro Hospitalar do Porto-Hospital de Santo Antonio E.P.E.
🇵🇹Porto, Portugal
FSBI "Russian Research Centre of Radiology and Surgical Technologies
🇷🇺Saint-Petersburg, Pesochniy, Russian Federation
State Budgetary Institution of Healthcare "Leningrad Regional Clinical Hospital"
🇷🇺Saint Petersburg, Russian Federation
Kantonsapotheke Zuerich
🇨🇭Zuerich, Switzerland
Gaziantep Universitesi Sahinbey Arastirma ve Uygulama
🇹🇷Gaziantep, Turkey
Hospital Clínico Universitario Virgen de la Arrixaca
🇪🇸El Palmar, Murcia, Spain
GBUZ of Yaroslavl Region "Regional Clinical Hospital"
🇷🇺Yaroslavl, Russian Federation
Hospital Clinico Universitario Virgen de la Arrixaca
🇪🇸El Palmar, Murcia, Spain
The Medical Oncology Centre of Rosebank
🇿🇦Johannesburg, Gauteng, South Africa
Complejo Hospitalario Universitario A Coruna
🇪🇸A Coruna, Spain
Department of Medical Oncology, University of Pretoria, Steve Biko Academic Hospitals Complex
🇿🇦Pretoria, Gauteng, South Africa
CETIR, Centre Medic
🇪🇸Barcelona, Spain
Inselspital Bern
🇨🇭Bern, Switzerland
Hospital Universitario Sanitas La Moraleja
🇪🇸Madrid, Spain
Universitatsspital Basel
🇨🇭Basel, Switzerland
City Hospitals Sunderland NHS Foundation Trust-Sunderland Royal Hospital
🇬🇧Sunderland, United Kingdom
Barts Health NHS Trust
🇬🇧London, United Kingdom
H. Quiron Zaragoza
🇪🇸Zaragoza, Spain
Department of Radiology, Ramathibodi Hospital
🇹🇭Bangkok, Thailand
Integra Gurses Teshis Tedavi ve Saglik Hizmetleri A.S.
🇹🇷Ankara, Turkey
Ultramar Tibbi Goruntuleme Merkezi
🇹🇷Ankara, Turkey
Adnan Menderes University Medical Faculty
🇹🇷Aydin, Turkey
EGE-RAD Bilgisayarli Tomografi Ozel Saglik Hizmetleri ve Malzemeleri Tic.Ltd.Sti.
🇹🇷Izmir, Turkey
Southend University Hospital NHS Foundation Trust
🇬🇧Westcliff-On-Sea, Essex, United Kingdom
Celal Bayar University Medical Faculty
🇹🇷Manisa, Turkey
"MedX-rey International Group" LLC
🇺🇦Obukhiv District, KYIV Region, Ukraine
Ondokuz Mayis Universitesi Tip Fakultesi
🇹🇷Samsun, Turkey
MI 'City Dnipropetrovsk Multi-field Clin. Hospital #4 of DRC',
🇺🇦Dnipropetrovsk, Ukraine
"Central City Clinical Hospital, City Oncology Center, SHEI ""Uzhhorod National University"", Chair
🇺🇦Uzhhorod, Ukraine
"Municipal Institution ""Chernivtsi Regional Clinical Oncology Center"",
🇺🇦Chernivtsi, Ukraine
Positron Emission Tomography (PET) Centre
🇬🇧Newcastle upon Tyne, United Kingdom
Klinikum Stuttgart, Klinik fuer Nuklearmedizin
🇩🇪Stuttgart, Germany
Klinikum Chemnitz gGmbH - Institut fuer Interventionelle Radiologie und Neuroradiologie
🇩🇪Chemnitz, Germany
Klinikum Chemnitz gGmbH - Klinik fuer Nuklearmedizin
🇩🇪Chemnitz, Germany
Klinikum Chemnitz gGmbH - Zentralapotheke
🇩🇪Chemnitz, Germany
Universitatsklinikum Essen (AoR)
🇩🇪Essen, Germany
Universitaetsmedizin Rostock
🇩🇪Rostock, Germany
Vinzenz von Paul Kliniken gGmbH
🇩🇪Stuttgart, Germany
Radiologie Rhein-Sieg
🇩🇪Troisdorf, Germany
Hospital Rey Juan Carlos
🇪🇸Mostoles, Madrid, Spain
Hospital Modelo
🇪🇸A Coruna, Spain
Hospital Del Mar
🇪🇸Barcelona, Spain
Hospital Quiron de Barcelona, IEC
🇪🇸Barcelona, Spain
Centro CIMES
🇪🇸Malaga, Spain
Radiodiagnostic CETIR - Clinica del Pilar
🇪🇸Barcelona, Spain
Hospital universitario Virgen de la Victoria
🇪🇸Malaga, Spain
Centro Mario Gallegos
🇪🇸Malaga, Spain
Complejo Hospitalario de Ourense. Hematología
🇪🇸Ourense, Spain
Hospital Universitario Virgen del Rocio
🇪🇸Sevilla, Spain
Hospital de Dia Quiron Zaragoza
🇪🇸Zaragoza, Spain
Torrance Health Association DBA, Torrance Memorial Physician, Network/Cancer Care Associates
🇺🇸Redondo Beach, California, United States
John D. Archbold Memorial Hospital
🇺🇸Thomasville, Georgia, United States
Lewis Hall Singletary Oncology Center At John D. Archbold Memorial Hospital
🇺🇸Thomasville, Georgia, United States
Vidant Medical Center
🇺🇸Greenville, North Carolina, United States
Cancer Center,Northwestern Medicine, West Region
🇺🇸Geneva, Illinois, United States
San Antonio Military Medical Center
🇺🇸Fort Sam Houston, Texas, United States
Comprehensive Cancer Center at Desert Regional Medical Center
🇺🇸Palm Springs, California, United States
Charite - Universitaetsmedizin Berlin
🇩🇪Berlin, Germany
Investigational Products Center (IPC)
🇺🇸Fort Worth, Texas, United States
Saint Louise Regional Hospital Radiology Department (Radiology Only)
🇺🇸Gilroy, California, United States
South Valley Imaging Center (Imaging Only)
🇺🇸Gilroy, California, United States
Northwestern Medicine West Region
🇺🇸DeKalb, Illinois, United States
Investigational Products Center (I PC)
🇺🇸Fort Worth, Texas, United States
Nuclear Medicine Department
🇧🇪Brussels, Belgium
Hospital Santa Izabel - Setor de Bioimagem
🇧🇷Salvador, Bahia, Brazil
C.H.U. Ambroise Pare
🇧🇪Mons, Belgium
Hospital Santa Izabel / Santa Casa de Misericordia da Bahia
🇧🇷Salvador, Bahia, Brazil
Radiology Department
🇧🇪La Louviere (Haine-Saint-Paul), Belgium
Hospital das Clinicas da Universidade Federal de Goias \ Centro de Pesquisa Clinica
🇧🇷Goiania, GO, Brazil
Centro de Imagens da Faculdade de Medicina - INCT Medicina Nuclear - PET/CT
🇧🇷Belo Horizonte, MG, Brazil
Uniao Brasileira de Educacao e Assistencia (UBEA) - Hospital Sao Lucas da PUCRS -
🇧🇷Porto Alegre, RS, Brazil
CDI - Centro de Diagnostico por Imagem do Hospital Sao Lucas da PUCRS
🇧🇷Porto Alegre, RS, Brazil
InsCer - Instituto do Cerebro do Rio Grande do Sul - PUCRS
🇧🇷Porto Alegre, RS, Brazil
Fundacao Amaral Carvalho / Fundacao Dr. Amaral Carvalho
🇧🇷Jau, SAO Paulo, Brazil
CEMEDI
🇧🇷Campinas, SP, Brazil
Tecnolab
🇧🇷Sao Bernardo do Campo, SAO Paulo, Brazil
Casa da Esperanca
🇧🇷Santo Andre, SAO Paulo, Brazil
CH de Mulhouse, Hopital Emile Muller
🇫🇷Mulhouse, Mulhouse Cedex, France
IEP São Lucas (Pharmacy)
🇧🇷São Paulo, SP, Brazil
Hospital Bandeirantes
🇧🇷Sao Paulo, SP, Brazil
Instituto Radium
🇧🇷Campinas, SP, Brazil
CAEP - Centro Avancado de Estudos e Pesquisas LTDA
🇧🇷Campinas, SP, Brazil
Hospital das Clinicas da Faculdade de Medicina da USP / Fundacao Faculdade de Medicina MEC MPAS
🇧🇷Sao Paulo, SP, Brazil
Centre Hospitalier De Bourg En Bresse
🇫🇷Bourg En Bresse Cedex, France
IEP Sao Lucas - Instituto de Ensino e Pesquisa Sao Lucas / HEMOMED - Instituto de Oncologia e
🇧🇷Sao Paulo, Brazil
Hopital Duchenne Chu - Boulogne Sur Mer
🇫🇷Boulogne Sur Mer, France
Centre Hospitalier Universitaire Cote de Nacre
🇫🇷Caen, France
Fleury
🇧🇷Sao Paulo, Brazil
Hopital Morvan-CHU Brest- Service Hematologie Clinique
🇫🇷Brest, France
Centre Hospitalier du Mans
🇫🇷Le Mans, France
Clinique de la Sauvegarde
🇫🇷Lyon, France
Apotheke des St. Anna Hospital
🇩🇪Herne, Germany
Klinikum Chemnitz gGmbH
🇩🇪Chemnitz, Germany
Zentralapotheke
🇩🇪Troisdorf, Germany
Gen.Hosp.of Athens "Evangelismos-Eye Hosp.-polikiliniki"
🇬🇷Athens, Greece
Ueberoertliche Berufsausuebungsgemeinschaft Drs. med. Helmut Forstbauer
🇩🇪Troisdorf, Germany
Global Hospitals
🇮🇳Hyderabad, Telangana, India
Istituto Europeo di Oncologia
🇮🇹Milano, MI, Italy
Unità semplice di Medicina Nucleare
🇮🇹Latina, NAP, Italy
U.O. Ematologia 1 - IRCCS AOU San Martino-IST
🇮🇹Genova, GE, Italy
IRST - IRCCS U. O. Oncologia Medica
🇮🇹Meldola, FC, Italy
SC Ematologia - SC Ematologia - Arcispedale Santa Maria Nuova - IRCCS
🇮🇹Reggio Emilia, Reggio, Italy
IRCSS A.O.U. San Martino - IST - UO Clinica Ematologica
🇮🇹Genova, Italy
National Hospital Organization Osaka Minami Medical Center
🇯🇵Kawachinagano, Osaka, Japan
National Hospital Organization Kumamoto Medical Center
🇯🇵Kumamoto-shi, Kumamoto-ken, Japan
Hallym University Sacred Heart Hospital
🇰🇷Anyang-si, Gyeonggi-do, Korea, Republic of
Yamagata University Hospital
🇯🇵Yamagata-Shi, Yamagata, Japan
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Gyeonggi-do, Korea, Republic of
Ulsan University Hospital
🇰🇷Ulsan, Korea, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Chonbuk National University Hospital
🇰🇷Jeonju-si, Jeollabuk-do, Korea, Republic of
Centro Universitario de Imagen Diagnostica, Radiologia e Imagen del Hospital Universitario
🇲🇽Monterrey, Nuevo LEON, Mexico
Ain Wazein Hospital
🇱🇧Mount Lebanon, Lebanon
Imagenus
🇲🇽Mexico City, Distrito Federal, Mexico
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
🇲🇽Monterrey, Nuevo LEON, Mexico
Pet Scan Peru
🇵🇪Lima, Peru
Caribe MRI and CT
🇵🇷Ponce, Puerto Rico
CT Clinic S.R.L.
🇷🇴Cluj-Napoca, Romania
Spitalul Clinic Colentina
🇷🇴Bucuresti, Romania
FSBI "Russian Research Centre of Radiology and Surgical Technologies n.a. A.M. Granov" of MoH of RF
🇷🇺Saint-Petersburg, Pesochniy, Russian Federation
Russian Cancer Research Centre them N.N. Blokhin
🇷🇺Moscow, Russian Federation
SBHI of Stavropol Region "Pyatigorsk Interdistrict Oncology Dispensary
🇷🇺Pyatigorsk, Stavropol Region, Russian Federation
Yaroslavl State Medical Academy
🇷🇺Yaroslavl, Russian Federation
NIKSCH & PARTNERS t/a CAPITAL RADIOLOGY
🇿🇦Pretoria, Gauteng, South Africa
Drs Bloch & Partners Incorporated
🇿🇦Sandton, Gauteng, South Africa
Dr JN De Jong and Partners t/a East Rad
🇿🇦Pretoria, Gauteng, South Africa
Albert Alberts Stem Cell Transplant Centre
🇿🇦Pretoria, Gauteng, South Africa
Onkologikoa
🇪🇸San Sebastian, Guipuzcoa, Spain
Drs Sulman & Partners Specialist Radiologists
🇿🇦Rosebank, Gauteng, South Africa
Hospital Universitario Puerta del Mar
🇪🇸Cadiz, Spain
Hospital Universitario Fundacion Jimenez Diaz
🇪🇸Madrid, Spain
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Eg. ve Aras.
🇹🇷Ankara, Turkey
Municipal Non-Profit Enterprise "Regional Oncology Centre"
🇺🇦Kharkiv, Ukraine
Diagnostic Imaging
🇬🇧Sunderland, United Kingdom
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Holy Cross Hospital Hospital Pharmacy
🇺🇸Silver Spring, Maryland, United States
Holy Cross Hospital
🇺🇸Silver Spring, Maryland, United States
Rcca Md Llc
🇺🇸Bethesda, Maryland, United States
Charite - Universitatsmedizin Berlin, Campus Virchow-Klinikum
🇩🇪Berlin, Germany
Pathology Department, Unique Hospital Multispeciality & Research Institute
🇮🇳Surat, Gujarat, India
SBHI of Moscow City Clinical Hospital n.a. S.P.Botkin of Healthcare Department of Moscow
🇷🇺Moscow, Russian Federation
Ruby Hall clinic
🇮🇳Pune, Maharashtra, India