Neurological Changes With a Memory Self-efficacy Training Protocol

Not Applicable

Completed

• Conditions: Mild Cognitive Impairment
• Interventions: Behavioral: General Education; Behavioral: Memory Self-Efficacy Training

• Registration Number: NCT04077320
• Lead Sponsor: Western University, Canada

Brief Summary

Confidence in one's ability to accomplish a task, more formally known as self-efficacy, is an important psychological variable that can influence how the investigators perform on various tasks. Previous studies have shown that self-efficacy is a modifiable trait that can be improved and bolstered with training and practice. More importantly for this study, memory self-efficacy has been shown to be modifiable for older adults, consequently improving their performance on memory tasks. While there is evidence to support the importance of memory self-efficacy for successful memory performance in older adults, the underlying neurological changes that accompany these performance changes have not been explored. The goal of this study is to examine the changes in brain activity before and after a memory self-efficacy training program to better understand the mechanisms of both memory and self-efficacy.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-08-28
• Study First Submitted QC: 2019-09-03
• Study First Posted: 2019-09-04
• Study Start: 2023-08-01
• Primary Completion: 2024-09-23
• Study Completion: 2024-09-23
• Status Verified: 2024-10
• Last Update Submitted: 2024-10-11
• Last Update Posted: 2024-10-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

1. Subjective memory complaints within past 5 years
2. Objective memory impairment below age norms on standardized cognitive testing
3. Score below 25 on Montreal Cognitive Assessment
4. Scores 1.5 standard deviations below age norms on memory testing
5. Unimpaired performance in Activities of Daily Living
6. Intact general cognition
7. Fluently read, write and speak English
8. Right handed

Exclusion Criteria

1. Co-morbidity that would impact cognition (depression, anxiety, stroke)
2. Prior diagnosis of dementia of any type
3. Use of prescription or recreational drug use that would impact cognition (excluding hormone replacement therapy)
4. Uncorrected visual or auditory deficits/impairments
5. Current participation in alternate study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
General Education Group	General Education	General education group classes (e.g., exercise, diet, sustainability, tc.)
Memory Self-Efficacy Training	Memory Self-Efficacy Training	Memory self-efficacy group training classes.

Primary Outcome Measures

Name	Time	Method
Neurological bio-markers: Regional activation	Pre and Post intervention - 6 weeks	Using fMRI identify changes in activation patterns or signal change when performing an associative memory task
Neurological bio-markers: Default mode network	Pre and Post intervention - 6 weeks	Using fMRI during a resting state observe changes in default mode network activation

Secondary Outcome Measures

Name	Time	Method
Story Recall - Trained memory performance task	Pre and Post intervention - 6 weeks	Observe the changes in memory performance using measures that were specifically practiced in the training intervention. Recall of a short story to estimate episodic memory capacity.
Face-Name Pairs - Trained memory performance tasks	Pre and Post intervention - 6 weeks	Observe the changes in memory performance using measures that were specifically practiced in the training intervention. Recall of a face-name pairs to evaluate associative memory.
Digit Span Task - Untrained memory performance tasks	Pre and Post intervention - 6 weeks	Observe the changes in memory performance using measures that were not specifically practiced in the training intervention.; A series of numbers are verbally presented, increasing in length for the participant to repeat back. Measures working memory
List Recall - Trained memory performance tasks	Pre and Post intervention - 6 weeks	Observe the changes in memory performance using measures that were specifically practiced in the training intervention. Recall of a visually presented list of unrelated words to estimate episodic memory capacity and working memory.
RAVLT - Untrained memory performance tasks	Pre and Post intervention - 6 weeks	Observe the changes in memory performance using measures that were not specifically practiced in the training intervention.; Participants are asked to recall a list of verbally presented words immediately after presentation and after a delay. Used to evaluate sort term verbal memory and long term memory
Visual Spatial Learning Task - Untrained memory performance tasks	Pre and Post intervention - 6 weeks	Observe the changes in memory performance using measures that were not specifically practiced in the training intervention.; Subjects are given time to learn the location and design of shapes on a 6 x 4 matrix. Subjects are required to correctly select the 7 correct shapes from a selection of 15 and place them on the grid. Used to measure visual spatial memory
Face-Scene Pairs - Untrained memory performance tasks	Pre and Post intervention - 6 weeks	Observe the changes in memory performance using measures that were not specifically practiced in the training intervention.; An alternative form of evaluating associative memory ability. Participants will be given face and scene pairs to remember.

Trial Locations

Locations (1)

Community; 🇨🇦 London, Ontario, Canada