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Clinical Trials/NCT02458547
NCT02458547
Completed
Not Applicable

Effect of Anesthesia Technique on Outcome After Hip Fracture Surgery in Elderly Adult Patients

Yonsei University1 site in 1 country186 target enrollmentMay 2015

Overview

Phase
Not Applicable
Intervention
Bupivacaine
Conditions
Hip Fracture
Sponsor
Yonsei University
Enrollment
186
Locations
1
Primary Endpoint
HMGB1
Status
Completed
Last Updated
7 years ago

Overview

Brief Summary

Despite many previous studies, whether anesthetic technique will significantly affect overall patient outcome, morbidity and mortality in elderly hip fracture patients is controversial. Due to old age, poor patient condition and emergent clinical settings, patients undergoing surgical procedures for hip fracture management are often subject to poor postoperative outcome and high mortality rates. While many studies have reported that regional anesthesia leads to improved postoperative outcome after hip fracture surgery, others have concluded otherwise. Moreover, because the majority of these previous studies are retrospective cohorts or systemic reviews, there is a need for randomized clinical trials to provide high quality evidence. This study aims to compare patient outcome between three different anesthetic techniques in elderly patients undergoing surgery for hip fracture management by evaluating proinflammatory cytokines, chemistry lab testing and clinical outcome between general anesthesia with either desflurane or propofol-based TIVA and spinal anesthesia with bupivacaine.

Registry
clinicaltrials.gov
Start Date
May 2015
End Date
January 21, 2019
Last Updated
7 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Patients older than 65 years scheduled for elective or emergency hip fracture surgery.

Exclusion Criteria

  • Patient refusal
  • Inflammation or wound at puncture site, increased intracranial pressure, bleeding diathesis
  • Allergies to propofol or its ingredients, soybeans or peanuts
  • Patients with altered mental status
  • Illiterate patients or foreigners

Arms & Interventions

Group S

Spinal anesthesia with 0.5% bupivacaine

Intervention: Bupivacaine

Group D

General anesthesia with desflurane

Intervention: Desflurane

Group P

General anesthesia with propofol total intravenous anesthesia

Intervention: Propofol

Outcomes

Primary Outcomes

HMGB1

Time Frame: from preoperative baseline to 72hours

IL-6

Time Frame: from preoperative baseline to 72hours

NT-proBNP

Time Frame: from preoperative baseline to 72hours

hemoglobin

Time Frame: from preoperative baseline to 72hours

total lymphocyte count

Time Frame: from preoperative baseline to 72hours

albumin

Time Frame: from preoperative baseline to 72hours

creatinine

Time Frame: from preoperative baseline to 72hours

potassium

Time Frame: from preoperative baseline to 72hours

troponin-T

Time Frame: from preoperative baseline to 72hours

CRP

Time Frame: from preoperative baseline to 72hours

Study Sites (1)

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