Skip to main content
MedPath Trial logoMedPath TrialMedPath Trial Home
Clinical Trials/NCT01464086
NCT01464086CompletedPhase 3

LIFSCREEN : Evaluation of Whole Body MRI for Early Detection of Cancers in Subjects With P53 Mutation (Li-Fraumeni Syndrome)

Gustave Roussy, Cancer Campus, Grand Paris1 site in 1 country107 target enrollmentStarted: October 27, 2011Last updated:
Share to TwitterShare to FacebookShare to LinkedInShare to Reddit
Conditions
Interventions

Trial Snapshot

Phase
Phase 3
Status
Completed
Enrollment
107
Locations
1
Primary Endpoint
cancer incidence
Study OverviewStudy DesignEligibility CriteriaArms & InterventionsOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

The purpose of this study is to compare the diagnostic efficacy of two follow-up schedules for the early detection of cancers in the population under study on cancer incidence at 3 years.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Diagnostic
Masking
None

Eligibility Criteria

Ages
5 Years to 71 Years (Child, Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •P53 mutation

Exclusion Criteria

  • Not provided

Arms & Interventions

Standard arm

No Intervention

standard follow-up

Intensive follow-up

Experimental

Standard follow-up plus whole body MRI at inclusion, one and two years

Intervention: whole body MRI (Other)

Outcomes

Primary Outcomes

cancer incidence

Time Frame: 3 years

cancer incidence during the first 3 years

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

Loading locations...

Similar Trials

Completed
Not Applicable
Whole-body MRI in Pediatric Hodgkin's LymphomaHodgkin's Lymphoma
NCT04005703UMC Utrecht75
Completed
Not Applicable
Evaluation of MRI of the Pineal Gland in RetinoblastomaRetinoblastoma
NCT06367569Amsterdam UMC, location VUmc607
Completed
Not Applicable
Comparative and Additive Diagnostic Performance of Magnetic Resonance Elastography (MRE) and Corrected-T1 (cT1) for Fibrosis and Inflammation in Nonalcoholic Steatohepatitis (NASH) Using Histology As ReferenceLiver InflammationNonalcoholic SteatohepatitisLiver FibrosesNonalcoholic Fatty Liver
NCT04389593University of California, San Diego30
Completed
Not Applicable
Advanced MR Imaging for Early Biologic Tumor Changes to Neoadjuvant Chemoradiation Treatment for Rectal CancerRectal Cancer
NCT01830582Memorial Sloan Kettering Cancer Center28
Completed
Not Applicable
Assessment of Early Treatment Response by Diffusion and Perfusion MRI in Patients With Brain MetastasisBrain Cancer
NCT01974804Memorial Sloan Kettering Cancer Center30