To Examine Whether or Not the Primary Causes of OA or RA Might be Bone Alterations

Recruiting

Conditions: Progression of Rheumatoid Arthritis
Osteoarthritis of Multiple Joints

Interventions: Procedure: The examinations for bones in joints of OA and RA patients

Brief Summary: Generally, osteoarthris (OA) is considered as primarily cartilage disease. However, as we and others have previously reported, a portion of OA might be caused primarily by bone alterations. In this study, we prospectively and retrospectively show that the bone altertations may affect OA primarily in all of the joints.

In addition, rheumatoid arthritis (RA) is a joint disease when immune system attacks synovium. Joint destruction occurrs continuously if suitable treatment is not performed. The etiology of RA is still largely unknown. As with OA, RA can be primarily damaged in bone, instead of cartilage. Here we prospectively and retrospectively show that the bone altertations may affect RA primarily in all of the joints.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Arm && Interventions

Group	Intervention	Description
RA and OA	The examinations for bones in joints of OA and RA patients	Every 2 or 3 months, plain radiograph, blood and urinary tests, and MRI are performed in the painful joints of RA.

Primary Outcome Measures

Name	Time	Method
The bone signal changes detected by MRI in OA and/or RA patients	1 year

Secondary Outcome Measures

Name	Time	Method

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