To Examine Whether or Not the Primary Causes of OA or RA Might be Bone Alterations

Recruiting

• Conditions: Progression of Rheumatoid Arthritis; Osteoarthritis of Multiple Joints

• Registration Number: NCT02327650
• Lead Sponsor: Shinshu University

Brief Summary

Generally, osteoarthris (OA) is considered as primarily cartilage disease. However, as we and others have previously reported, a portion of OA might be caused primarily by bone alterations. In this study, we prospectively and retrospectively show that the bone altertations may affect OA primarily in all of the joints.

In addition, rheumatoid arthritis (RA) is a joint disease when immune system attacks synovium. Joint destruction occurrs continuously if suitable treatment is not performed. The etiology of RA is still largely unknown. As with OA, RA can be primarily damaged in bone, instead of cartilage. Here we prospectively and retrospectively show that the bone altertations may affect RA primarily in all of the joints.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-12-21
• Study First Submitted QC: 2014-12-24
• Study First Posted: 2014-12-30
• Study Start: 2015-11
• Status Verified: 2021-09
• Last Update Submitted: 2021-09-20
• Last Update Posted: 2021-09-21
• Primary Completion: 2022-04
• Study Completion: 2024-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• RA and/or OA

Exclusion Criteria

• N/A

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The bone signal changes detected by MRI in OA and/or RA patients	1 year

Trial Locations

Locations (1)

Yukio Nakamura; 🇯🇵 Matsumoto, Japan