Effect of preoperative use of intravenous tranexamic acid in reducing blood loss during caeserean section:Double blinded randomised controlled trial
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 94
- 试验地点
- 1
- 主要终点
- TO COMPARE THE DIFFERENCE IN INTRAOPERATIVE BLOOD LOSS DURING C SECTION AFTER PROPHYLACTIC ADMINISTRATION OF 1G IV TRANEXEMIC ACID
研究概览
简要总结
Tranexamic acid (TXA) has been extensively studied for its efficacy and safety in reducing blood loss during and after caesarean section (CS), a procedure associated with increased risk of postpartum hemorrhage (PPH)Regarding safety, TXA administration was associated with a reduced risk of PPH and transfusions, with no significant increase in thromboembolic events . Minor side effects were more common in the TXA group than in the control group, but these were not clinically significant .In conclusion, prophylactic administration of TXA before caesarean section is an effective and safe intervention to reduce blood loss and associated complications. Its use is particularly advantageous in settings where blood conservation is critical and in patients at higher risk of bleeding.
研究设计
- 研究类型
- Interventional
- 分配方式
- Stratified block randomization
- 盲法
- Double Blind Double Dummy
入排标准
- 年龄范围
- 18.00 Year(s) 至 45.00 Year(s)（—）
- 性别
- Female
入选标准
- •pregnant women above 18 years.
- •All consenting women undergoing caeserean section.
排除标准
- •Exclusion criteria Non consenting patients Prior history of Thromboembolism and bleeding disorders Patients on Anticoagulants Acute Fetal Distress •Failed instrumental delivery Exclusion criteria: •Non consenting patients •Prior history of Thromboembolism and bleeding disorders.
- ••Patients on Anticoagulants •Acute Fetal Distress •Failed instrumental delivery.
结局指标
主要结局
TO COMPARE THE DIFFERENCE IN INTRAOPERATIVE BLOOD LOSS DURING C SECTION AFTER PROPHYLACTIC ADMINISTRATION OF 1G IV TRANEXEMIC ACID
时间窗: AFTER 10 MINS OF SKIN CLOSURE
次要结局
- TO compare need of additional uterotonics drugs & measures(To compare side effects)