Effect of Cornus mas L. on Inflammatory Risk Factors, Lipid Profile and Apolipoproteins in Dyslipidemic Children
Trial Snapshot
- Phase
- Phase 1
- Status
- Completed
- Enrollment
- 40
Study Overview
Brief Summary
Abstract Cornus mas L. (CM) fruits are rich in anthocyanins
and possess both antiinflammatory and antioxidant
activities. The current study was conducted to investigate
whether supplementation with CM could ameliorate lipid
profile and vascular inflammation in dyslipidemic children
and adolescents. In this randomized clinical trial, 40 dyslipidemic
children and adolescents ages 9 to 16 years
were assigned to receive 50 g of CM twice a day after
lunch and dinner (n = 20, case group) or to continue their
normal diet (n = 20, control group). The serum levels of
total cholesterol (TC), low-density lipoprotein cholesterol
(LDL-C), high-density lipoprotein cholesterol (HDL-C),
triglycerides (TG), apo A-I, apo B, intracellular adhesion
molecule-1 (ICAM-1), vascular cell adhesion molecule-1
(VCAM-1), C-reactive protein (CRP), and anthropometric
indices were determined at baseline and then after weeks 3
and 6 of the trial. After week 6 of the trial, the TC, TG,
LDL-C, apo B, ICAM-1, and VCAM-1 levels in the CM
group were significantly lower and the HDL-C and apo A-I
levels higher than at baseline. After week 6 of the trial,
none of these parameters in the control group, except for
ICAM-1, was significantly altered from baseline. However,
between-group comparison showed a significant difference
only for apo A-I (p = 0.016) and a borderline significant
difference for ICAM-1 (p = 0.076). No significant difference
in body mass index, waist-to-hip ratio, or C-reactive
protein was observed between the studied groups. The
present findings revealed a trend toward amelioration of
lipid profile and vascular inflammation following addition
of CM to the daily diet of dyslipidemic children and adolescents
but this needs to be verified by larger scale trials.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 9 years to 16 years (—)
- Sex
- All
Inclusion Criteria
- •subjects that had at least one of the dyslipidemic measures such as TG (=150 mg/dL), TC (=170 mg/dL), LDL (=130 mg/dL) and low HDL (<35 mg/dL) in serum; dyslipidemic children between the ages of 9-16 years.
- •Exclusion criteria: known diabetes mellitus; liver disease; nephrotic syndrome; thyroid disorders; chronic pancreatitis; bile duct disorders; the use of medication that would alter lipid metabolism; the informed consent not being signed.
Exclusion Criteria
- Not provided