A randomized controlled clinical trial to study the effect of brahmi churna in smrutibransha with special reference to senile dementia

-     Smruti is the remembrance of things by concentrated mind, directly perceived, heard or experienced earlier. If the person is not able to grasp or retain the present events or experiences, it is known as ‘Smrutivibhransa’. When the mind of any person is covered by the Rajasa and Moha its activities are being taken to such an extent that one cannot be able to recollect the memory stored as it is related to Tatvagyana. This condition is termed as ‘Smrutibransha’ which can be correlated with Senile Dementia in modern science. Dementia is a chronic organic mental disorder, characterized by progressive usually irreversible, global cognitive deficit. It is a condition in which one’s thinking and remembering ability gradually hampers. The estimated Senile dementia prevalence for adults ages 60 above in India is 7.4%. Brahmi Churna has been selected as it is tiktarasatmak, laghugunatmak, sheetvirya , madhuraviryatmak ,vaatpittaharka , medhya rasayan. It primarily either acts via antioxidant mechanism (i.e., neuroprotection) or alters different neurotransmitters (serotonin (5-hydroxytryptamine, 5-HT), dopamine (DA), acetylcholine (ACh), γ-aminobutyric acid (GABA)) to execute the pharmacological effect. The patients within the age group of 60-80 years who fulfill the clinical assessment criteria for senile dementia & having symptoms of Smrutibransha mentioned in the classics, patients are selected irrespective of sex, socio-economic status, and community, written consent from both patient and their relatives will be taken prior to the study. Computerised generated sampling technique will be used. Total 60 number of patients will be selected and divided into two groups, named as Group A (trial group) and Group B (Control group).Brahmi Churna Group A (trial group)  with dose 3gm bd with anupana goghrit and Tablet Donepezil Group B(Control group) with dose 5mg will be given to patients. Both drugs will be administered in churna form & tablet respectively for 45 days. Observations will be done on day 0, day 15, day 30 and day 45. Result of study will be drawn on basis of criteria of assessment and statistical analysis. Discussion will be done on the basis of observations and result obtained during the treatment. Summary will be drawn and whole thesis work will be summarized. Conclusion will be drawn strictly on basis of statistical analysis and will be unbiased.