EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved)
- Registration Number
- NCT03057951
- Lead Sponsor
- Boehringer Ingelheim
- Brief Summary
This is a study in adults with chronic heart failure. People with chronic heart failure may need to be hospitalised for their condition. Some people with chronic heart failure may eventually die from their condition. The purpose of the study is to find out whether a medicine called empagliflozin lowers the chances of patients having to go to hospital for heart failure and whether it improves their survival. The study is open to patients with a type of chronic heart failure called chronic heart failure with preserved ejection fraction.
Participants stay in the study until researchers have enough information about how effective empagliflozin is. It is expected that participants who enter at the very beginning of the enrolment period may be in the study for over 3 years, while participants who enter near the end of the enrolment period may be in the study for less than 2 years. The participants are put into 2 groups. It is decided by chance who gets into which group. One group gets empagliflozin tablets every day and the other group gets placebo tablets every day. Placebo tablets look like empagliflozin tablets but contain no medicine.
Participants visit the doctors regularly. During these visits, the doctors collect information about the participant's health. The doctors want to know how many patients had to go to hospital because of heart failure or who died from cardiovascular disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 5988
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo - 10 mg Empagliflozin Empagliflozin -
- Primary Outcome Measures
Name Time Method Time to First Event of Adjudicated Cardiovascular (CV) Death or Adjudicated Hospitalisation for Heart Failure (HHF) From randomization until completion of the planned treatment phase, up to 1403 days. Failure with preserved Ejection Fraction (HFpEF). The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 \* number of patients with event / time at risk \[years\].
Time at risk \[years\] = Sum of time at risk \[days\] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
- Secondary Outcome Measures
Name Time Method Occurrence of Adjudicated Hospitalisation for Heart Failure (HHF) (First and Recurrent) From randomization until completion of the planned treatment phase, up to 1403 days. Reported is the total number of adjudicated HHF events (first and recurrent) which occurred.
Change From Baseline in Kansas City Cardiomyopathy Questionaire (KCCQ) Clinical Summary Score at Week 52 At baseline and at week 12, week 32 and week 52. The KCCQ is a 23-item self-administered questionnaire designed to evaluate physical limitations, symptoms (frequency, severity, and changes over time), social limitations, self-efficacy, and quality of life in patients with Heart Failure. The KCCQ-clinical summary score comprises the following domains: Symptom frequency, symptom burden and physical limitation. The score is calculated by summing domain responses and then transforming scores to a 0-100 unit scale with higher scores indicating better health status.
For patients who died, a worst score (score of 0) was imputed for the score at all subsequent scheduled visits after the date of death where the score would have been assessed.
Change from baseline in KCCQ-score at week 52 was modeled using a MMRM with visit (week 12, 32 and 52) as repeated measures, adjusted mean (standard error) at week 52 is reported.Occurrence of All-cause Hospitalisation (First and Recurrent) From randomization until completion of the planned treatment phase, up to 1403 days. Occurrence of all-cause hospitalisation (first and recurrent). Total number of all cause hospitalisations is reported.
eGFR (CKD-EPI) cr Slope of Change From Baseline At baseline, week 4, 12, 32, 52, 76, 100, 124, 148, 172 and week 196, up to 1043 days. Glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula with serum creatinine measurement (eGFR(CKD-EPI)cr) slope of change from baseline.
Available on-treatment change-from-baseline data were used. The slope represents the long term effect of eGFR change from baseline and provides the yearly rate of decline.
Timepoints after baseline were included in calculation of slope of change from baseline.
The slope per patient was calculated using a random coefficient model with terms for treatment, region, baseline status of diabetes, age, sex, left ventricular ejection fraction (LVEF) and glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula (eGFR (CKD-EPI)cr) at baseline and in addition the factors "time", "treatment-by-time interaction", and "baseline eGFR (CKD-EPI)cr-by-time interaction".Time to the First Event in the Composite Renal Endpoint: Chronic Dialysis, Renal Transplant, or Sustained Reduction in eGFR (CKD-EPI)cr From randomization until completion of the planned treatment phase, up to 1403 days. Chronic dialysis was defined as dialysis with a frequency of twice per week or more for at least 90 days.
Sustained was determined by two or more consecutive post-baseline central laboratory measurement separated by at least 30 days.
Reduction in glomerular filtration rate estimated by the chronic kidney disease epidemiology collaboration formula with serum creatinine measurement (eGFR (CKD-EPI)cr) was defined as reduction in eGFR from baseline ≥40%, eGFR \<15 mL/min/1.73 m\^2 for patients with baseline eGFR ≥30 mL/min/1.73 m\^2, or eGFR \<10 mL/min/1.73 m\^2 for patients with baseline eGFR \<30 mL/min/1.73 m\^2.
The incidence rate per 100 patient years (100 \* number of patients with event / time at risk \[years\]) is reported. Time at risk \[year\] is calculated as: Sum of time at risk \[days\] over all patients in a treatment group / 365.25.
Abbreviation:
Patient-years (pt-yrs).Time to First Adjudicated Hospitalisation for Heart Failure (HHF) From randomization until completion of the planned treatment phase, up to 1403 days. Time to first adjudicated HHF. The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 \* number of patients with event / time at risk \[years\].
Time at risk \[years\] = Sum of time at risk \[days\] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.Time to Adjudicated Cardiovascular (CV) Death From randomization until completion of the planned treatment phase, up to 1403 days. Time to adjudicated CV death. The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 \* number of patients with event / time at risk \[years\].
Time at risk \[years\] = Sum of time at risk \[days\] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.Time to All-cause Mortality From randomization until completion of the planned treatment phase, up to 1403 days. Time to all-cause mortality. The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 \* number of patients with event / time at risk \[years\].
Time at risk \[years\] = Sum of time at risk \[days\] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.Time to Onset of Diabetes Mellitus (DM) in Patients With Pre-DM From randomization until completion of the planned treatment phase, to 1403 days. Time to onset of DM (defined as HbA1c ≥6.5% or as diagnosed by the investigator) in patients with pre-DM.
Pre-DM was defined as no history of DM and no HbA1c ≥6.5% before treatment, and a pre-treatment HbA1c value of ≥5.7% and \<6.5%.
The incidence rate per 100 patient years (pt-yrs) is presented and calculated as followed:
Incidence rate per 100 pt-yrs = 100 \* number of patients with event / time at risk \[years\].
Time at risk \[years\] = Sum of time at risk \[days\] over all patients in a treatment group / 365.25.
Patients without a specific endpoint event were censored at the last date the patient was known to be free of the event or at the end of the planned treatment period, whichever was earlier.
Trial Locations
- Locations (610)
Atlanta Heart Specialists, LLC
🇺🇸Tucker, Georgia, United States
North Shore University Hospital
🇺🇸Manhasset, New York, United States
Covigilant Research, LLC
🇺🇸Riverside, California, United States
Palmetto Health
🇺🇸Columbia, South Carolina, United States
Clearwater Cardiovascular Consultants
🇺🇸Safety Harbor, Florida, United States
Morton Plant Mease Health Care
🇺🇸Clearwater, Florida, United States
Grady Clinical Research Center
🇺🇸Atlanta, Georgia, United States
Northwest Heart Clinical Research, LLC
🇺🇸Arlington Heights, Illinois, United States
Midwest Cardiovascular Research and Education Foundation
🇺🇸Elkhart, Indiana, United States
Soltero Cardiovascular Research Center
🇺🇸Dallas, Texas, United States
University of Texas Southwestern Medical Center
🇺🇸Dallas, Texas, United States
University of Texas Medical Branch at Galveston
🇺🇸Galveston, Texas, United States
Royal Adelaide Hospital
🇦🇺Adelaide, South Australia, Australia
North York Diagnostic and Cardiac Centre
🇨🇦Toronto, Ontario, Canada
Kagawa Prefectural Central Hospital
🇯🇵Kagawa, Takamatsu, Japan
VA Northeast Ohio Healthcare System
🇺🇸Cleveland, Ohio, United States
Angiocardiac Care of Texas
🇺🇸Houston, Texas, United States
Virginia Mason Medical Center
🇺🇸Seattle, Washington, United States
Elite Clinical Research
🇺🇸Miami, Florida, United States
Cardiovascular Research Center of South Florida
🇺🇸Miami, Florida, United States
St. Francis Medical Group-Indiana Heart Physicians, Inc
🇺🇸Indianapolis, Indiana, United States
Healthcare Partners LLC
🇺🇸Las Vegas, Nevada, United States
Renmin Hospital of Wuhan University
🇨🇳Wuhan, China
St. Boniface General Hospital
🇨🇦Winnipeg, Manitoba, Canada
Mount Hospital
🇦🇺Perth, Western Australia, Australia
Clinica Mayo
🇦🇷San Miguel de Tucuman, Argentina
Liège - HOSP CHR de la Citadelle
🇧🇪Liège, Belgium
B.M. Birla Heart research Centre
🇮🇳Kolkatta, India
Siddhi Hospital
🇮🇳Nashik, India
G.A. Research Associates Ltd
🇨🇦Moncton, New Brunswick, Canada
Palm Research Center
🇺🇸Las Vegas, Nevada, United States
Garden State Heart Care, PC
🇺🇸Manalapan, New Jersey, United States
Hospital Italiano Regional del Sur, Bahia Blanca
🇦🇷Bahia Blanca, Argentina
Hospital Italiano de Buenos Aires
🇦🇷Caba, Argentina
Centro Médico Viamonte
🇦🇷Ciudad Autonoma de Bs As, Argentina
Hospital Privado de Comunidad
🇦🇷Mar del Plata, Argentina
UZ Leuven
🇧🇪Leuven, Belgium
Clinique Santé Cardio MC
🇨🇦Montreal, Quebec, Canada
Vancouver General Hospital
🇨🇦Vancouver, British Columbia, Canada
Sanford Research
🇺🇸Sioux Falls, South Dakota, United States
Royal University Hospital
🇨🇦Saskatoon, Saskatchewan, Canada
Advanced Heart Care, LLC
🇺🇸Bridgewater, New Jersey, United States
Centro de Investigaciones Médicas
🇦🇷Mar del Plata, Argentina
Victoria Heart Institute Foundation
🇨🇦Victoria, British Columbia, Canada
IPS Centro Cientifico Asistencia
🇨🇴Barranquilla, Colombia
IPS Centro Medico Julián Coronel S.A.
🇨🇴Cali, Colombia
Centro de Investigaciones Clinicas S.A.S
🇨🇴Cali, Colombia
Apex Cardiology/ Research Associates of Jackson
🇺🇸Jackson, Tennessee, United States
Nebraska Heart Institute
🇺🇸Grand Island, Nebraska, United States
Instituto Medico Elsa Perez SRL (IMEP)
🇦🇷Ciudadela, Argentina
Sanatorio Mayo Privado SA
🇦🇷Córdoba, Argentina
Instituto Medico Fundación Grupo Colaborativo Rosario
🇦🇷Rosario, Argentina
Instituto CAICI
🇦🇷Rosario, Argentina
Centro Cardiovascular Salta
🇦🇷Salta, Argentina
Centro de Diagnostico Cardilogico
🇨🇴Cartagena, Colombia
QEII Health Sciences Centre
🇨🇦Halifax, Nova Scotia, Canada
LSU Health Sciences Center
🇺🇸New Orleans, Louisiana, United States
The Stern Cardiovascular Center
🇺🇸Germantown, Tennessee, United States
University Hospital Geelong
🇦🇺Geelong, Victoria, Australia
Montreal General Hospital - McGill University Health Centre
🇨🇦Montreal, Quebec, Canada
Centro de Reumatologia y Ortopedia SAS, Barranquilla
🇨🇴Barranquilla, Colombia
Fundación Cardiovascular de Colombia
🇨🇴Floridablanca, Colombia
Promotora Medica Las Americas SA
🇨🇴Medellin, Colombia
Lausmed Kft. Outpatient Unit of Internal Medicine
🇭🇺Baja, Hungary
Narayana Institute of Cardiac Sciences
🇮🇳Bangalore, India
Apollo Speciality Hospital
🇮🇳Chennai, India
Maine Research Associates
🇺🇸Lewiston, Maine, United States
Investigaciones Clinicas Tucuman
🇦🇷San Miguel de Tucumán, Argentina
Centro Medico Luquez
🇦🇷San Vicente, Argentina
Centro de Investigaciones Clínicas del Litoral
🇦🇷Santa Fe, Argentina
Hospital "Dr. José Maria Cullen"
🇦🇷Santa Fé, Argentina
Clínica Olivos
🇦🇷Vicente Lopez, Argentina
Ziekenhuis Oost-Limburg - Campus Sint-Jan
🇧🇪Genk, Belgium
Corazon IPS S.A.S.
🇨🇴Barranquilla, Colombia
Centro cardiovascular Aristides
🇨🇴Cartagena, Colombia
Studium Egeszseghaz Kft.
🇭🇺Kalocsa, Hungary
Selye Janos Hospital Komarom
🇭🇺Komarom, Hungary
Sir Gangaram Hospital
🇮🇳New Delhi, India
Japanese Red Cross Nagoya Daini Hospital
🇯🇵Aichi, Nagoya, Japan
Endocare Research Institute
🇨🇴Bogota, Colombia
Fundación Valle del Lili
🇨🇴Cali, Colombia
Belgyogyaszati es Kardiologiai Maganrendelo
🇭🇺Bekescsaba, Hungary
Bugat Pal Hospital, Gyongyos
🇭🇺Gyongyos, Hungary
Dr. Nagy Laszlo Kardiologiai Maganrendeles
🇭🇺Oroshaza, Hungary
GNRC Hospital
🇮🇳Guwahati, India
GB Pant Hospital
🇮🇳New Delhi, India
Matsuyama Shimin Hospital
🇯🇵Ehime, Matsuyama, Japan
Steel Memorial Yawata Hospital
🇯🇵Fukuoka, Kitakyushu, Japan
Japan Community Health Care Organization Kyushu Hospital
🇯🇵Fukuoka, Kitakyushu, Japan
Shirakawa Kosei General Hospital
🇯🇵Fukushima, Shirakawa, Japan
Tomakomai City Hospital
🇯🇵Hokkaido, Tomakomai, Japan
Hyogo Prefectural Amagasaki General Medical Center
🇯🇵Hyogo, Amagasaki, Japan
Budai Irgalmasrendi Korhaz
🇭🇺Budapest, Hungary
Fejer County Saint George University Teaching Hospital
🇭🇺Szekesfehervar, Hungary
Kamalnayan Bajaj Hospital
🇮🇳Aurangabad, India
Fukuoka University Chikushi Hospital
🇯🇵Fukuoka, Chikushino, Japan
Otaru Kyokai Hospital
🇯🇵Hokkaido,Otaru, Japan
San-Ai Hospital
🇯🇵Saitama, Saitama, Japan
Kosekai Iwatsuki-minami Hospital
🇯🇵Saitama, Saitama, Japan
Catharina Ziekenhuis
🇳🇱Eindhoven, Netherlands
University of Pecs
🇭🇺Pecs, Hungary
Da Vinci Private Clinic
🇭🇺Pecs, Hungary
Vijan Cardiac and Critical Care Centre
🇮🇳Nasik, India
Fortis Escorts Heart Institute
🇮🇳New Delhi, India
Kimitsu Chuo Hospital
🇯🇵Chiba, Kisarazu, Japan
Saiseikai Fukuoka General Hospital
🇯🇵Fukuoka, Fukuoka, Japan
Kyushu University Hospital
🇯🇵Fukuoka, Fukuoka, Japan
Kitano Hospital
🇯🇵Osaka, Osaka, Japan
Yodogawa Christian Hospital
🇯🇵Osaka, Osaka, Japan
Hokusetsu General Hospital
🇯🇵Osaka, Takatsuki, Japan
Tokushima Prefectural Central Hospital
🇯🇵Tokushima, Tokushima, Japan
Onze Lieve Vrouwe Gasthuis
🇳🇱Amsterdam, Netherlands
Maastricht University
🇳🇱Maastricht, Netherlands
Chiba Heart Clinic
🇯🇵Chiba, Chiba, Japan
Fukuokaken Saiseikai Futsukaichi Hospital
🇯🇵Fukuoka, Chikushino, Japan
Ogaki Municipal Hospital
🇯🇵Gifu, Ogaki, Japan
Fukuyama City Hospital
🇯🇵Hiroshima, Fukuyama, Japan
Matsuda Cardiovascular Clinic
🇯🇵Hokkaido, Sapporo, Japan
Krakow Specialistic Hospital of John Paul II
🇵🇱Krakow, Poland
Lukmed Lukasz Wozniak
🇵🇱Siedlce, Poland
S.C Medicali's S.R.L
🇷🇴Timisoara, Romania
Seiwakai Suizenji Touya Hospital
🇯🇵Kumamoto, Kumamoto, Japan
National Hospital Organization Sendai Medical Center
🇯🇵Miyagi, Sendai, Japan
Amphia Ziekenhuis
🇳🇱Breda, Netherlands
Szpital Zakonu Bonifratow Sp. z o.o.
🇵🇱Katowice, Poland
ETG Skierniewice
🇵🇱Skierniewice, Poland
ETG Warszawa
🇵🇱Warszawa, Poland
C.M.D.T.A. NEOMED, Brasov
🇷🇴Brasov, Romania
Clinica Medicala Data Plus SRL
🇷🇴Bucuresti, Romania
Tokushukai Koga General Hospital
🇯🇵Ibaraki, Koga, Japan
National Hospital Organization Kanazawa Medical Center
🇯🇵Ishikawa, Kanazawa, Japan
Kumamoto Rosai Hospital
🇯🇵Kumamoto, Yatsushiro, Japan
Omi Medical Center
🇯🇵Kusatsu, Japan
Rode Kruis Ziekenhuis Beverwijk
🇳🇱Beverwijk, Netherlands
ETG Lodz
🇵🇱Lodz, Poland
Nzoz Salus
🇵🇱Lodz, Poland
NZOZ HEUREKA, Piaseczno
🇵🇱Piaseczno, Poland
Spitalul Clinic Colentina
🇷🇴Bucuresti, Romania
Specialistic Cardiology&Hypertension Out-patient Clin,Kielce
🇵🇱Kielce, Poland
Leszek Bryniarski Specialized Medical Cabinet
🇵🇱Krakow, Poland
Zgierskie Center of Cardiology MED-PRO
🇵🇱Zgierz, Poland
Emergency University Hospital, Bucharest
🇷🇴Bucharest, Romania
S.C Cardiomed S.R.L
🇷🇴Craiova, Romania
National University Hospital
🇸🇬Singapore, Singapore
National Heart Center
🇸🇬Singapore, Singapore
Spitalul Clinic "Prof. Dr. Theodor Burghele"
🇷🇴Bucuresti, Romania
Spital Judetean Deva
🇷🇴Deva, Romania
Azienda Ospedaliera Universitaria "Federico II"
🇮🇹Napoli, Italy
University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
University of California San Francisco
🇺🇸San Francisco, California, United States
Tokyo Rosai Hospital
🇯🇵Tokyo, Ota-ku, Japan
Oita Medical Center
🇯🇵Oita, Oita, Japan
Naha City Hospital
🇯🇵Okinawa, Naha, Japan
Advent Health Medical Group
🇺🇸Tampa, Florida, United States
University of South Florida
🇺🇸Tampa, Florida, United States
M Heffernan Medicine Professional Corp.
🇨🇦Oakville, Ontario, Canada
Scarborough Cardiology Research
🇨🇦Scarborough, Ontario, Canada
Cardiovascular Contract Research Organization LTD
🇨🇦Sudbury, Ontario, Canada
Long Beach Center for Clinical Research
🇺🇸Long Beach, California, United States
Valley Clinical Trials, Inc.
🇺🇸Northridge, California, United States
Merced Vein and Vascular Center
🇺🇸Merced, California, United States
University of California Irvine
🇺🇸Orange, California, United States
South Denver Cardiology Associates, PC
🇺🇸Littleton, Colorado, United States
Blue Coast Cardiology
🇺🇸Vista, California, United States
Nature Coast Clinical Research
🇺🇸Inverness, Florida, United States
Integrative Research Associates
🇺🇸Fort Lauderdale, Florida, United States
Cardiovascular Group PC
🇺🇸Lawrenceville, Georgia, United States
Mount Sinai Hospital
🇺🇸Chicago, Illinois, United States
Captain James A. Lovell Federal Health Care Center
🇺🇸North Chicago, Illinois, United States
Reid Hospital
🇺🇸Richmond, Indiana, United States
Iowa Heart Center
🇺🇸Des Moines, Iowa, United States
Clinical Trials of America, LLC
🇺🇸Monroe, Louisiana, United States
Regions Hospital
🇺🇸Saint Paul, Minnesota, United States
Research Integrity, LLC
🇺🇸Owensboro, Kentucky, United States
Grace Research, LLC
🇺🇸Bossier City, Louisiana, United States
Maryland Cardiovascular Specialists
🇺🇸Baltimore, Maryland, United States
MD Medical Research
🇺🇸Oxon Hill, Maryland, United States
Anne Arundel Medical Center
🇺🇸Annapolis, Maryland, United States
MedStar Health Research Institute
🇺🇸Baltimore, Maryland, United States
Metropolitan Cardiovascular Consultants
🇺🇸Beltsville, Maryland, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
East Mountain Medical Associates, PC
🇺🇸Great Barrington, Massachusetts, United States
McLaren Northern Michigan Hospital
🇺🇸Petoskey, Michigan, United States
Bozeman Health Clinical Research
🇺🇸Bozeman, Montana, United States
Jackson Heart Clinic, P.A.
🇺🇸Jackson, Mississippi, United States
CHI Health Midlands
🇺🇸Papillion, Nebraska, United States
Capital Cardiology Associates, PC
🇺🇸Albany, New York, United States
Mount Sinai - PRIME
🇺🇸New York, New York, United States
Trinity Medical WNY, PC
🇺🇸Cheektowaga, New York, United States
Harlem Cardiology
🇺🇸New York, New York, United States
Northwell Health
🇺🇸Southampton, New York, United States
Clinical Trials of America, Inc
🇺🇸Lenoir, North Carolina, United States
South Oklahoma Heart Research Group
🇺🇸Oklahoma City, Oklahoma, United States
Rama Research LLC
🇺🇸Marion, Ohio, United States
Clinical Research of Rock Hill
🇺🇸Rock Hill, South Carolina, United States
Palmetto Research Center, LLC
🇺🇸Spartanburg, South Carolina, United States
Methodist University Hospital
🇺🇸Memphis, Tennessee, United States
Seton Heart Institute
🇺🇸Austin, Texas, United States
University of North Texas Health Science Center
🇺🇸Fort Worth, Texas, United States
Cardiac Health Management Network, P.C.
🇺🇸Chester, Virginia, United States
Medical College of Virginia Hospitals
🇺🇸Richmond, Virginia, United States
Meriter Wisconsin Heart
🇺🇸Madison, Wisconsin, United States
Aspirus Research Institute
🇺🇸Wausau, Wisconsin, United States
Hospital Interzonal General de Agudos Dr Jose Penna
🇦🇷Bahia Blanca, Argentina
CIPREC
🇦🇷Caba, Argentina
Instituto Cardiovascular de Buenos Aires
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Instituto Médico DAMIC S.R.L.
🇦🇷Cordoba, Argentina
CER Instituto Médico
🇦🇷Quilmes, Argentina
Instituto de Investigaciones Clínicas de Quilmes
🇦🇷Quilmes, Argentina
Sanatorio Británico
🇦🇷Rosario, Argentina
Centro de Investigaciones Clinicas Instituto del Corazon
🇦🇷Córdoba, Argentina
Instituto de Investigaciones Clinicas de Rosario
🇦🇷Rosario, Argentina
CORDIS S.A., Salta
🇦🇷Salta, Argentina
Adelaide Medical Research
🇦🇺Ashford, South Australia, Australia
Heart and Vascular Research
🇦🇺Fullarton, South Australia, Australia
The Northern Hospital
🇦🇺Epping, Victoria, Australia
Grand Hôpital de Charleroi
🇧🇪Gilly, Belgium
Hospital Vera Cruz
🇧🇷Belo Horizonte, Brazil
Jessa Ziekenhuis - Campus Virga Jesse
🇧🇪Hasselt, Belgium
La Louvière - UNIV CHU Tivoli
🇧🇪La Louvière, Belgium
Centro Especializado em Cardiol Loema Instituto de Pesq Clin
🇧🇷Campinas, Brazil
FGM - Clínica Paulista de Doenças Cardiovasculares
🇧🇷Bela Vista, Brazil
IPECC - Instituto de Pesquisa Clínica de Campinas
🇧🇷Campinas, Brazil
L2IP -Instituto de Pesquisas Clínicas Ltda.
🇧🇷Brasília, Brazil
Instituto de Cardiologia Rio Grande do Sul
🇧🇷Porto Alegre, Brazil
Irmandade da Santa Casa de Misericordia de Curitiba
🇧🇷Campina Grande do Sul, Brazil
Hospital Universitário
🇧🇷Canoas, Brazil
IPCEM - Instituto de Pesquisa Clínica para Estudos Multicêntricos - Universidade de Caxias do Sul
🇧🇷Caxias do Sul, Brazil
Hospital Felicio Rocho
🇧🇷Belo Horizonte, Brazil
CAEP - Centro Avançado de Estudos e Pesquisas Ltda.,Campinas
🇧🇷Campinas, Brazil
ICDF - Instituto de Cardiologia do Distrito Federal
🇧🇷Brasília, Brazil
Irmandade da Santa Casa de Misericórdia de Curitiba
🇧🇷Curitiba, Brazil
Via Medica
🇧🇷Goiânia, Brazil
Centro de Pesquisas em Diabetes
🇧🇷Porto Alegre, Brazil
HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
🇧🇷Goiânia, Brazil
Santa Casa de Misericórdia de Porto Alegre
🇧🇷Porto Alegre, Brazil
Hospital Universitário Pedro Ernesto UERJ
🇧🇷Rio de Janeiro, Brazil
Cardresearch Cardiologia Assistencial e de Pesquisas Ltda
🇧🇷Santa Efigenia, Brazil
Hospital de Clínicas de Porto Alegre
🇧🇷Porto Alegre, Brazil
Praxis Pesquisa Médica
🇧🇷Santo André, Brazil
CEPIC - Centro Paulista de Investigacao Clinica
🇧🇷Sao Paulo, Brazil
CEMEC - Centro Multidisciplinar de Estudos Clínicos
🇧🇷São Bernardo do Campo, Brazil
Dr. Consulta
🇧🇷São Paulo, Brazil
Hospital Agamenon Magalhaes
🇧🇷Recife, Brazil
CEDOES - Diagnóstico e Pesquisa,Vitória
🇧🇷Vitória, Brazil
Pesquisare
🇧🇷Santo André, Brazil
Hospital de Base - Fac Med de Sao Jose do Rio Preto
🇧🇷Sao Jose do Rio Preto, Brazil
Centro de Pesquisa Clinica - CPCLIN
🇧🇷Sao Paulo, Brazil
INCOR e Hospital das Clínicas da Universidade de São Paulo
🇧🇷Sao Paulo, Brazil
CCBR - Rio de Janeiro - BR
🇧🇷Rio de Janeiro, Brazil
PACE (Partners in Advanced Cardiac Evaluation)
🇨🇦Newmarket, Ontario, Canada
Curnew Medicine Professional Corporation
🇨🇦Hamilton, Ontario, Canada
Cambridge Cardiac Care Inc.
🇨🇦Cambridge, Ontario, Canada
CDEC BRASIL - Centro de Desenvolvimento em Estudos Clínicos Brasil
🇧🇷São Paulo, Brazil
Medical Arts Health Research Group
🇨🇦North Vancouver, British Columbia, Canada
Brampton Cardio Pulmonary Clinic
🇨🇦Brampton, Ontario, Canada
Brampton Research Associates
🇨🇦Brampton, Ontario, Canada
Hamilton General Hospital
🇨🇦Hamilton, Ontario, Canada
University Hospital (LHSC)
🇨🇦London, Ontario, Canada
JBN Medical Diagnostic Services Inc.
🇨🇦Burlington, Ontario, Canada
Dr. Saul Vizel
🇨🇦Cambridge, Ontario, Canada
Montreal Heart Institute
🇨🇦Montreal, Quebec, Canada
McGill University Health Centre (MUHC)
🇨🇦Montreal, Quebec, Canada
Canadian Phase Onward Inc.
🇨🇦Toronto, Ontario, Canada
2nd Xiangya Hospital of Central South University
🇨🇳Changsha, China
The First Affiliated Hospital of Fujian Medical University
🇨🇳Fuzhou, China
Mohan Babapulle Medicine Professional Medicine
🇨🇦Waterloo, Ontario, Canada
Guangzhou First Municipal People's Hospital
🇨🇳Guangzhou, China
ViaCar Recherche Clinique Inc
🇨🇦Greenfield Park, Quebec, Canada
Cardiovascular Institute and Fu Wai Hospital
🇨🇳Beijing, China
First Hospital of Jilin University
🇨🇳Changchun, China
Hunan Provincial People's Hospital
🇨🇳Changsha, China
IUCPQ (Laval University)
🇨🇦Quebec, Canada
Beijing Friendship Hospital
🇨🇳Beijing, China
The Third Hospital of Changsha
🇨🇳Changsha, China
Huashan Hospital, Fudan University
🇨🇳Shanghai, China
Dongguan People's Hospital
🇨🇳Dongguan, China
Haikou People's Hospital
🇨🇳Haikou, China
HaiNan Provincial People's Hospital
🇨🇳Haikou, China
The First Affiliated Hospital of Lanzhou University
🇨🇳Lanzhou, China
The Second Affiliated Hospital of Lanzhou Medical University
🇨🇳Lanzhou, China
CardioColombia S.A.S.
🇨🇴Bogota D.C, Colombia
Nanchang University Affiliated 3rd Hospital
🇨🇳Nanchang, China
The Affiliated Hospital of Southwest Medical University
🇨🇳Luzhou, China
Yanbian University Hospital
🇨🇳Yanji, China
the first people hospital of Yue Yang
🇨🇳Yueyang, China
Tianjin Union Medical Center Nankai University Affiliated Hospital
🇨🇳Tianjin, China
Tongji Hospital, Tongji University
🇨🇳Wuhan, China
First Affiliated Hospital of Xi'an JiaoTong University
🇨🇳Xi'an, China
Affiliated Hospital of Jiangsu University
🇨🇳Zhenjiang, China
Asociacion IPS Medicos Internistas de Caldas
🇨🇴Manizales, Colombia
Internal and Cardiology Practice, MUDr. Karel Kamenik, Brno
🇨🇿Brno, Czechia
Fakultni nemocnice u sv. Anny v Brne
🇨🇿Brno, Czechia
Vojenska nemocnice Brno
🇨🇿Brno, Czechia
Univ.Hosp U Svate Anny, I.Internal Clinic-Cardiology,Brno
🇨🇿Brno, Czechia
Edumed s.r.o
🇨🇿Broumov, Czechia
InterKardioML s.r.o.
🇨🇿Marianske Lazne, Czechia
Milit.Hosp.-State Health Cent.
🇭🇺Budapest, Hungary
Nehezlegzes Ambulancia
🇭🇺Debrecen, Hungary
Rajarajeswari Medical College
🇮🇳Bengaluru, India
Madras Medical Mission,
🇮🇳Chennai, India
Kasugai Municipal Hospital
🇯🇵Aichi, Kasugai, Japan
Doctor Jivraj Mehta Smarak Health Foundation
🇮🇳Ahmedabad, India
AOU Policlinico Umberto I
🇮🇹Roma, Italy
IRCCS Gruppo Multimedica
🇮🇹Sesto San Giovanni (MI), Italy
Azienda Servizi Sanitari 1 Triestina
🇮🇹Trieste, Italy
Azienda Ospedaliera G. Rummo
🇮🇹Benevento, Italy
Batra Hospital and Medical Research Centre
🇮🇳New Delhi, India
Gemeinschaftspraxis Dres Haggenmiller/Jeserich
🇩🇪Nürnberg, Germany
ClinPhenomics GmbH & Co KG, Frankfurt
🇩🇪Frankfurt, Germany
University Debrecen Hospital
🇭🇺Debrecen, Hungary
Universitätsmedizin Göttingen, Georg-August-Universität
🇩🇪Göttingen, Germany
University Thomayer's Hospital
🇨🇿Praha 4 - Krc, Czechia
Kardio Vaclavik s.r.o.
🇨🇿Prerov, Czechia
ASST Papa Giovanni XXIII - A.O. Papa Giovanni XXIII
🇮🇹Bergamo, Italy
Sendai Kousei Hospital
🇯🇵Miyagi, Sendai, Japan
Istituto Clinico Humanitas
🇮🇹Rozzano (MI), Italy
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
🇮🇹Roma, Italy
Azienda Ospedaliera Universitaria Arcispedale Sant'Anna
🇮🇹Cona (FE), Italy
Ospedale della Val di Chiana Santa Margherita
🇮🇹Cortona, Italy
Milano Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico
🇮🇹Milano, Italy
Dorottya Kanizsai Hospital
🇭🇺Nagykanizsa, Hungary
Medifarma-98 Kft.
🇭🇺Nyiregyhaza, Hungary
Ehime Prefectural Central Hospital
🇯🇵Ehime, Matsuyama, Japan
Kardiologicka ambulance
🇨🇿Tremosna, Czechia
Universitätsklinikum Aachen, AöR
🇩🇪Aachen, Germany
KIGE s.r.o
🇨🇿Znojmo, Czechia
Kardiologicka ambulance MUDr. Ferkl s.r.o.
🇨🇿Trutnov, Czechia
PV-Kardiologie s.r.o.
🇨🇿Pardubice, Czechia
Corintez s.r.o.
🇨🇿Prague, Czechia
University Hospital Motol
🇨🇿Praha 5, Czechia
Shobara Red Cross Hospital
🇯🇵Hiroshima, Shobara, Japan
Teine Keijinkai Clinic
🇯🇵Hokkaido, Sapporo, Japan
Yamamoto Clinic
🇯🇵Kanagawa, Sagamihara, Japan
Japanese Red Cross Kumamoto Hospital
🇯🇵Kumamoto, Kumamoto, Japan
Mitoyo General Hospital
🇯🇵Kagawa, Kanonji, Japan
National Hospital Organization Kobe Medical Center
🇯🇵Hyogo, Kobe, Japan
Sekishinkai Second Kawasaki Saiwai Clinic
🇯🇵Kanagawa, Kawasaki, Japan
Kanagawa Cardiovascular and Respiratory Center
🇯🇵Kanagawa, Yokohama, Japan
Miyazaki Medical Association Hospital
🇯🇵Miyazaki, Miyazaki, Japan
Hokushin General Hospital
🇯🇵Nagano, Nakano, Japan
Okayama City General Medical Center
🇯🇵Okayama, Okayama, Japan
Nagasaki Medical Center
🇯🇵Nagasaki, Omura, Japan
Uji-Tokushukai Medical Center
🇯🇵Kyoto, Uji, Japan
Sendai Tokushukai Hospital
🇯🇵Miyagi, Sendai, Japan
Nanbu Tokushukai Hospital
🇯🇵Okinawa, Shimajiri-gun, Japan
Urasoe General Hospital
🇯🇵Okinawa, Urasoe, Japan
Higashiosaka City Medical Center
🇯🇵Osaka, Higashiosaka, Japan
Sekino Hospital
🇯🇵Tokyo, Toshima-ku, Japan
Minami Wakayama Medical Center
🇯🇵Wakayama, Tanabe, Japan
National Hospital Organization Tokyo Medical Center
🇯🇵Tokyo, Meguro-ku, Japan
Chungbuk National University Hospital
🇰🇷Cheongju-si, Korea, Republic of
Ome Municipal General Hospital
🇯🇵Tokyo, Ome, Japan
Chonnam National University Hospital
🇰🇷Gwangju, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Hospital Cardiologica Aguascalientes
🇲🇽Aguascalientes, Mexico
Centro de Investigacion Biomedica y Farmaceutica, S.C.
🇲🇽Distrito Federal, Mexico
Hospital Ramon Garibay
🇲🇽Guadalajara, Mexico
Diseño y Planeación en Investigación Médica SC
🇲🇽Guadalajara, Mexico
Unidad de Investigacion Clinica Cardiometabolica de Occident
🇲🇽Guadalajara, Mexico
Cardiologia Clinica e Intervencionista
🇲🇽Guadalajara, Mexico
Centro de Investigación Clinica Acelerada, S.C.
🇲🇽Mexico, Mexico
Instituto Cardiovascular de Monclova, S de RL de CV
🇲🇽Monclova, Mexico
CEDOPEC-Ctro Esp en Diab, Obesidad y Prev de Enf Cardiovasc
🇲🇽México, Mexico
Centro Integral Medico SJR S.C.
🇲🇽San Juan del Rio, Mexico
Ziekenhuisgroep Twente locatie Almelo
🇳🇱Almelo, Netherlands
Onze Lieve Vrouwe Gasthuis, Locatie West
🇳🇱Amsterdam, Netherlands
Amsterdam UMC Locatie VUMC
🇳🇱Amsterdam, Netherlands
Amsterdam UMC, Locatie AMC
🇳🇱Amsterdam, Netherlands
Tergooiziekenhuizen locatie Blaricum
🇳🇱Blaricum, Netherlands
Ziekenhuis Gelderse Vallei
🇳🇱EDE, Netherlands
Universitair Medisch Centrum Groningen
🇳🇱Groningen, Netherlands
Franciscus Gasthuis
🇳🇱Rotterdam, Netherlands
Gelre Ziekenhuis Zutphen
🇳🇱Zutphen, Netherlands
Polsko-Amerykanskie Kliniki Serca
🇵🇱Chorzow, Poland
De Heel - Zaans Medisch Centrum
🇳🇱Zaandam, Netherlands
Univ. Clinic Hosp, Bialystok
🇵🇱Bialystok, Poland
KLIMED Marek Klimkiewicz
🇵🇱Bialystok, Poland
ClinicMed Badurski i wspolnicy Spolka Jawna, Bialystok
🇵🇱Bialystok, Poland
American Heart of Poland Sp. z o.o.
🇵🇱Ustron, Poland
NZOZ Centrum Medyczne KERmed
🇵🇱Bydgoszcz, Poland
Poradnia Kardiologiczna Jaroslaw Jurowiecki
🇵🇱Gdansk, Poland
University Clinical Center, Gdansk
🇵🇱Gdansk, Poland
Indywidualna Specjalistyczna Praktyka Lekarska
🇵🇱Gdynia, Poland
NZOZ Pro-Cordis Sopockie Centrum Bad. Kardiolog.
🇵🇱Gdynia, Poland
Individual Specialized Practice
🇵🇱Lodz, Poland
Lowickie Cardiology Center
🇵🇱Lowicz, Poland
Specialized Practice Dr. Janusz Spyra
🇵🇱Ruda Slaska, Poland
Centrum Medyczne Medyk
🇵🇱Rzeszow, Poland
KO-MED Centra Kliniczne Staszow
🇵🇱Staszow, Poland
The Provincial Polyclinical Hospital in Torun
🇵🇱Torun, Poland
Samodzielny Publiczny Centralny Szpital Kliniczny
🇵🇱Warszawa, Poland
CMDTA Washington, Bucharest
🇷🇴Bucharest, Romania
Into Research
🇿🇦Pretoria, South Africa
Emergency Clinical Hospital 'Sf. Panteliomon'
🇷🇴Bucharest, Romania
Prof.C.C.Iliescu Hospital, National Institute of Cardiology
🇷🇴Bucharest, Romania
Universitas Hospital Cardiology Research
🇿🇦Bloemfontein, South Africa
Spitalul Clinic Judetean de Urgenta, Timisoara
🇷🇴Timisoara, Romania
Tan Tock Seng Hospital
🇸🇬Singapore, Singapore
Cardiology Clinical Research
🇿🇦Alberton, South Africa
Hospital Puerta de Hierro
🇪🇸Majadahonda, Spain
MERC Research
🇿🇦Kempton Park, South Africa
Clinical Projects Research
🇿🇦Worcester, South Africa
Hospital Quiron. I.C.U.
🇪🇸Barcelona, Spain
Hospital Universitario Virgen de la Arrixaca
🇪🇸El Palmar, Spain
Dr JM Engelbrecht
🇿🇦Somerset West, South Africa
Hospital Santa Creu i Sant Pau
🇪🇸Barcelona, Spain
Hospital Sanitas CIMA
🇪🇸Barcelona, Spain
University Hospital of Wales
🇬🇧Cardiff, United Kingdom
St Bartholomew's Hospital
🇬🇧London, United Kingdom
St Mary's Hospital
🇬🇧Newport, United Kingdom
Barnet General Hospital
🇬🇧Barnet, United Kingdom
Glenfield Hospital
🇬🇧Leicester, United Kingdom
Hospital Virgen Macarena
🇪🇸Sevilla, Spain
Inje University Busan Paik Hospital
🇰🇷Busan, Korea, Republic of
Dong-A University Hospital
🇰🇷Busan, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Gyeonggi-Do, Korea, Republic of
Chungnam National University Hospital
🇰🇷Daejeon, Korea, Republic of
Severance Hospital
🇰🇷Seoul, Korea, Republic of
Wonju Severance Christian Hosp
🇰🇷Wonju-si, Korea, Republic of
St. Johannes Hospital Dortmund
🇩🇪Dortmund, Germany
Städtisches Klinikum Dresden
🇩🇪Dresden, Germany
Praxis Dr. Rieker, Berlin
🇩🇪Berlin, Germany
Vivantes Netzwerk für Gesundheit GmbH
🇩🇪Berlin, Germany
Charité - Universitätsmedizin Berlin
🇩🇪Berlin, Germany
Helios Klinikum Erfurt
🇩🇪Erfurt, Germany
Studienzentrum Bocholderstraße
🇩🇪Essen, Germany
Klinikum Bielefeld gGmbH
🇩🇪Bielefeld, Germany
Augusta-Kranken-Anstalt gGmbH
🇩🇪Bochum, Germany
Praxis Dr. Menzel
🇩🇪Dessau-Roßlau, Germany
Universitätsklinikum Carl Gustav Carus Dresden
🇩🇪Dresden, Germany
Medizinische Hochschule Hannover
🇩🇪Hannover, Germany
Universitätsklinikum des Saarlandes
🇩🇪Homburg, Germany
Universitätsklinikum Jena
🇩🇪Jena, Germany
Universitätsklinikum Schleswig-Holstein, Campus Kiel
🇩🇪Kiel, Germany
Asklepios Klinik Langen-Seligenstadt GmbH
🇩🇪Langen, Germany
Praxis Dr. Sarnighausen, Lüneburg
🇩🇪Lüneburg, Germany
Märkische Gesundheitsholding GmbH & Co. KG, Klinikum Lüdenscheid
🇩🇪Lüdenscheid, Germany
Katholisches Klinikum Mainz
🇩🇪Mainz, Germany
Zentrum für Klinische Forschung
🇩🇪Wangen im Allgäu, Germany
Kardiologische Praxis Papenburg
🇩🇪Papenburg, Germany
Praxis Dr. Stenzel, Riesa
🇩🇪Riesa, Germany
Petrus-Krankenhaus
🇩🇪Wuppertal, Germany
Kardiologische Praxis, Wermsdorf
🇩🇪Wermsdorf, Germany
Josephs-Hospital Warendorf
🇩🇪Warendorf, Germany
Corbod Research
🇿🇦Cape Town, South Africa
TREAD Research
🇿🇦Cape Town, South Africa
Clinresco
🇿🇦Johannesburg, South Africa
Chris Hani Baragwanath Hospital: Cardiology Department
🇿🇦Johannesburg, South Africa
Heart Center Research, LLC
🇺🇸Huntsville, Alabama, United States
St. Louis Center for Clinical Research
🇺🇸Saint Louis, Missouri, United States
St. Louis Heart and Vascular, P.C.
🇺🇸Saint Louis, Missouri, United States
Hospital Clínico de Santiago
🇪🇸Santiago de Compostela, Spain
Hospital Virgen de la Victoria
🇪🇸Malaga, Spain
Hospital General Universitario de Valencia
🇪🇸Valencia, Spain
Hospital General Universitario Gregorio Marañón
🇪🇸Madrid, Spain
Hospital Ramón y Cajal
🇪🇸Madrid, Spain
Hospital Arnau de Vilanova
🇪🇸Valencia, Spain
VA Greater Los Angeles Healthcare System
🇺🇸Los Angeles, California, United States
Integrated Heart Care
🇺🇸Boca Raton, Florida, United States
University of California
🇺🇸Torrance, California, United States
East Coast Institute for Research, LLC
🇺🇸Jacksonville, Florida, United States
Jacksonville Center for Clinical Research
🇺🇸Jacksonville, Florida, United States
Southeast Clinical Research, LLC
🇺🇸Chiefland, Florida, United States
Sarasota Memorial Hospital
🇺🇸Sarasota, Florida, United States
Advocate Health and Hospitals Corporation
🇺🇸Naperville, Illinois, United States
Rockford Cardiovascular Associates
🇺🇸Rockford, Illinois, United States
Beacon Medical Group Clinical Research
🇺🇸South Bend, Indiana, United States
Stony Brook University Medical Center
🇺🇸Stony Brook, New York, United States
Laurelton Heart Specialist, PC
🇺🇸Rosedale, New York, United States
Kernodle Clinic West
🇺🇸Burlington, North Carolina, United States
York Hospital, WellSpan Health
🇺🇸York, Pennsylvania, United States
Lycoming Internal Medicine, Inc
🇺🇸Jersey Shore, Pennsylvania, United States
Hunter Holmes McGuire VA Medical Center
🇺🇸Richmond, Virginia, United States
MUDr. Jan Hubac, s.r.o. Kardiologicka ambulance
🇨🇿Chrudim, Czechia
Zdenek Vomacka
🇨🇿Olomouc, Czechia
Nemocnice Trebic p.o.
🇨🇿Trebic, Czechia
Institute for Clinical and Experimental Medicine
🇨🇿Praha 4, Czechia
Clinical Trials Services s.r.o
🇨🇿Uherske Hradiste, Czechia
Cardiology Private Practice
🇨🇿Unicov, Czechia
Asheville Cardiology Associates
🇺🇸Asheville, North Carolina, United States
Universitätsklinikum Regensburg
🇩🇪Regensburg, Germany
Saratoga Clinical Research, LLC
🇺🇸Saratoga Springs, New York, United States
Uzsoki Street Hospital, Budapest
🇭🇺Budapest, Hungary
Dr. Louis C.H. Yao
🇨🇦York, Ontario, Canada
Clinexpert Kft.
🇭🇺Budapest, Hungary
Bajcsy-Zsilinszky Hospital and Clinic
🇭🇺Budapest, Hungary
Pinnacle Research Group, LLC
🇺🇸Anniston, Alabama, United States
Purushotham, Akther & Roshan Kotha, MD Inc.
🇺🇸La Mesa, California, United States
La Mesa Cardiac Center
🇺🇸La Mesa, California, United States
Orange County Research Center
🇺🇸Tustin, California, United States
Peninsula Research, Inc.
🇺🇸Ormond Beach, Florida, United States
Columbus Regional Research Institute
🇺🇸Columbus, Georgia, United States
Meridian Clinical Research, LLC
🇺🇸Savannah, Georgia, United States
Tufts Medical Center
🇺🇸Boston, Massachusetts, United States
Alpena General Hospital
🇺🇸Alpena, Michigan, United States
Saint Louis University
🇺🇸Saint Louis, Missouri, United States
Deaconess Billings Clinic Research Center
🇺🇸Billings, Montana, United States
Cardiac Care and Vascular Medicine, PLLC
🇺🇸Bronx, New York, United States
CHEAR Center LLC
🇺🇸Bronx, New York, United States
Long Island Cardiovascular Consultants
🇺🇸New Hyde Park, New York, United States
Novant Health Heart and Vascular Institute
🇺🇸Charlotte, North Carolina, United States
Clinical Research of Gastonia
🇺🇸Gastonia, North Carolina, United States
Doylestown Health Cardiology
🇺🇸Doylestown, Pennsylvania, United States
Richard M Kastelic and Associates
🇺🇸Johnstown, Pennsylvania, United States
Baylor Heart and Vascular Hospital
🇺🇸Dallas, Texas, United States
Biopharma Informatic, Inc. Research Center
🇺🇸Houston, Texas, United States
The Methodist Hospital
🇺🇸Houston, Texas, United States
Baylor Scott and White Health
🇺🇸Plano, Texas, United States
Private Practice Leadership, LLC
🇺🇸Katy, Texas, United States
Alpine Research Organization
🇺🇸Farmington, Utah, United States
Cardiology Consultants of Danville, Inc
🇺🇸Danville, Virginia, United States
Carient Heart and Vascular
🇺🇸Manassas, Virginia, United States
Roanoke Heart Institute PLC
🇺🇸Roanoke, Virginia, United States
Salem VA Medical Center
🇺🇸Salem, Virginia, United States
Cardiology Associates of Bellin Health
🇺🇸Green Bay, Wisconsin, United States
Marshfield Clinic
🇺🇸Marshfield, Wisconsin, United States
Glenny Corp. S.A. Bioclinica Argentina
🇦🇷Ciudad Autonoma Buenos Aires, Argentina
Consultorios Asociados de Endocrinología e Invest Clínica
🇦🇷Ciudad Autonoma de BuenosAires, Argentina
Sanatorio Güemes
🇦🇷Ciudad Autónoma de Bs As, Argentina
Clinica Privada Colombo- Fundacion Clinica Colombo
🇦🇷Cordoba, Argentina
Clinica Coronel Suarez SA
🇦🇷Coronel Suarez, Argentina
Instituto de Cardiología de Corrientes
🇦🇷Corrientes, Argentina
Sanatorio Allende S.A.
🇦🇷Córdoba, Argentina
Hospital Italiano de La Plata
🇦🇷La Plata, Argentina
Hospital Privado
🇦🇷Córdoba, Argentina
Sanatorio Plaza
🇦🇷Rosario, Argentina
Instituto de Cardiología
🇦🇷San Miguel de Tucuman, Argentina
Corporacion Medica de Gral. San Martin S.A.
🇦🇷San Martin, Argentina
CEMEDIC - Centro de Especialidades Medicas
🇦🇷Villa Luro, Argentina
Pendlebury Research
🇦🇺Kotara, New South Wales, Australia
John Hunter Hospital
🇦🇺New Lambton Heights, New South Wales, Australia
CORE Research Group
🇦🇺Milton, Queensland, Australia
Gold Coast University Hospital
🇦🇺Southport, Queensland, Australia
Flinders Medical Centre
🇦🇺Bedford Park, South Australia, Australia
Peninsula Private Hospital
🇦🇺Frankston, Victoria, Australia
AZ Maria Middelares
🇧🇪Gent, Belgium
AZ Sint-Blasius
🇧🇪Dendermonde, Belgium
C.H.U. de Charleroi
🇧🇪Charleroi, Belgium
CECAP - Centro de Cardiologia Clínica
🇧🇷Brasília, Brazil
ICM - Instituto do Coracao de Marilia
🇧🇷Marília, Brazil
Hospital São Vicente de Paulo
🇧🇷Passo Fundo, Brazil
H.C.da Fac. de Medicina de Ribeirao Preto
🇧🇷Ribeirao Preto, Brazil
Santa Casa de Votuporanga
🇧🇷Votuporanga, Brazil
Heart Health Institute
🇨🇦Scarborough, Ontario, Canada
The First Afiliated Hospital, Sun Yet-sen University
🇨🇳Guangzhou, China
Poliklinika Humanitas
🇨🇿Bilovec, Czechia
General Hospital of Shenyang Military Region
🇨🇳Shenyang, China
Shengjing Hospital of China Medical University
🇨🇳Shenyang, China
Gepamed s.r.o., Pulm. Outpat. Office, Hradec Kralove
🇨🇿Hradec Kralove, Czechia
Nemocnice Havlickuv Brod p.o.
🇨🇿Havlickuv Brod, Czechia
Nemocnice Milosrdnych bratri
🇨🇿Brno, Czechia
KardioLouny s.r.o.
🇨🇿Louny, Czechia
MUDr. Alexandra Ludkova
🇨🇿Brno, Czechia
University Hospital Brno
🇨🇿Brno, Czechia
Hospital Frydek Mistek
🇨🇿Frydek-Mistek, Czechia
Vseobecna fakultni nemocnice V Praze
🇨🇿Praha 2, Czechia
Angiocor s.r.o
🇨🇿Zlin, Czechia
Universitätsklinikum Heidelberg
🇩🇪Heidelberg, Germany
Gemeinschaftspraxis Drs. Kohler/Salbach, Mannheim
🇩🇪Mannheim, Germany
Deutsches Herzzentrum München
🇩🇪München, Germany
Veszpremi Sziv es Egeszseg Centrum
🇭🇺Veszprem, Hungary
Medanta-The Medicity
🇮🇳Gurgaon, India
Centro Cardiologico Monzino-IRCCS
🇮🇹Milano, Italy
Azienda Ospedaliera Universitaria Pisana
🇮🇹Pisa, Italy
Seikeikai New Tokyo Heart Clinic
🇯🇵Chiba, Matsudo, Japan
Uwajima City Hospital
🇯🇵Ehime, Uwajima, Japan
Fukuiken Saiseikai Hospital
🇯🇵Fukui, Fukui, Japan
National Hospital Organization Kyushu Medical Center
🇯🇵Fukuoka, Fukuoka, Japan
Chuno Kosei Hospital
🇯🇵Gifu, Seki, Japan
Hyogo Brain and Heart Center
🇯🇵Hyogo, Himeji, Japan
Mito Medical Center
🇯🇵Ibaraki, Higashiibaraki-gun, Japan
Kanmon Medical Center
🇯🇵Yamaguchi, Shimonoseki, Japan
Gachon University Gil Medical Center
🇰🇷Incheon, Korea, Republic of
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Hospital Universitario Dr Jose Eleuterio Gonzalez
🇲🇽Nuevo Leon, Mexico
Centro de Investigacion Cardiovascular y Metabolica
🇲🇽Tijuana, Mexico
Cardioarritmias e Investigación S.C
🇲🇽San Luis Potosi, Mexico
Centro de Investigacion Medica Alberto Bazzoni S.A. de C.V.
🇲🇽Torreon, Mexico
BovenIJ Ziekenhuis
🇳🇱Amsterdam, Netherlands
Zuyderland Medisch Centrum
🇳🇱Heerlen, Netherlands
Radboud Universitair Medisch Centrum
🇳🇱Nijmegen, Netherlands
Diaconessenhuis Meppel
🇳🇱Meppel, Netherlands
St. Antonius ziekenhuis, locatie Nieuwegein
🇳🇱Nieuwegein, Netherlands
Medicome Sp. z o.o.
🇵🇱Oswiecim, Poland
Spitalul Clinic De Urgenta "Prof. Dr. Agrippa Ionescu"
🇷🇴Balotesti, Romania
Park & St Francis Surgery
🇬🇧Eastleigh, United Kingdom
Specialist Hospital J. Dietla NZOZ Specialized Clinic "Gemini"
🇵🇱Zychlin, Poland
4. Military Clinical Hospital with Polyclinic SP ZOZ
🇵🇱Wroclaw, Poland
Khoo Teck Puat Hospital
🇸🇬Singapore, Singapore
Iatros International
🇿🇦Bloemfontein, South Africa
Hospital La Paz
🇪🇸Madrid, Spain
Tiervlei Trial Centre
🇿🇦Cape Town, South Africa
Excellentis Clinical Trials
🇿🇦George, South Africa
Morriston Hospital
🇬🇧Swansea, United Kingdom
Wycombe General Hospital
🇬🇧High Wycombe, United Kingdom
Korea University Guro Hospital
🇰🇷Seoul, Korea, Republic of
Orlando Health Inc.
🇺🇸Orlando, Florida, United States
Norton Heart Specialists
🇺🇸Louisville, Kentucky, United States
Saint Luke's Hospital of Kansas City
🇺🇸Kansas City, Missouri, United States
The University of North Carolina at Chapel Hill
🇺🇸Chapel Hill, North Carolina, United States
Lowcountry Center for Veterans Research
🇺🇸Charleston, South Carolina, United States
Royal Alexandra Hospital
🇨🇦Edmonton, Alberta, Canada
Accel Research Sites
🇺🇸DeLand, Florida, United States
The Queen Elizabeth Hospital
🇦🇺Woodville South, South Australia, Australia
Kawartha Cardiology Clinical Trials
🇨🇦Peterborough, Ontario, Canada
Semmelweis University
🇭🇺Budapest, Hungary
Centre de Dépistage et Recherche Cardiovasculaire Rive-Sud
🇨🇦Longeuil, Quebec, Canada
First Hospital Affiliated with Nanjing Medical University
🇨🇳Nanjing, China