EUCTR2012-005395-34-NL进行中（未招募）1 期
Prospective evaluation of the predictive value of a circulating tumor cell (CTC) sensitivity profile to Cisplatin chemotherapy in metastatic breast cancer patients - CTC-cDDP
适应症
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- Erasmus MC
- 入组人数
- 72
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- Female
入选标准
- •Female patient with metastatic breast cancer who has been pretreated with at least anthracycline and taxane-based chemotherapy in the adjuvant and/or metastatic setting
- •Measurable disease according to RECIST 1.1, ie at least one measurable lesion on CT-scan where the longest diameter in the plane of measurement is a minimum size of 10mm
- •Age = 18 years
- •WHO performance status =2
- •Adequate hematological functions defined as ANC = 1.0 x 109/L, platelets = 100 x 109/L
- •Adequate renal function defined as creatinin clearance = 60 mL/min (Cockcroft Gault)
- •Patients with reproductive potential must use a reliable method of contraception
- •Written informed consent
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 80
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range 20
排除标准
- •Other anticancer chemotherapy, use of biological response modifiers, or immunotherapy within two weeks prior to treatment start. Hormonal antitumor treatment within one week prior to treatment start.
- •Hearing loss of at least Common Terminology Criteria for Adverse Events (CTCAE) grade 2
- •Neuropathy of at least CTCAE grade 2
- •Pregnant or lactating patients
- •Serious illness or medical unstable condition prohibiting adequate treatment and follow-up
- •Symptomatic CNS metastases (the presence of at least one key symptom in combination with radiologic evidence (positive contrast-enhanced CT or MRI of the brain))
- •History of psychiatric disorder that would prohibit the understanding and giving of informed consent or that would prohibit adequate follow-up
研究者
相似试验
已完成
不适用
Prospective study of evaluation to the predictive biomarker of Nivolumab by tumor tissue specimen and neighboring bronchoaveolar lavage fluid (BALF) and BloodJPRN-UMIN000023822Respiratory Medicine, Allergy and Rheumatic Diseases Osaka University Graduate School of Medicine20
已完成
不适用
Observational study on the predictive value of the BAMCOG and cortisol levels for the incidence of Postoperative Delirium/Postoperative acute encephalopathy measured by the MoCA and the DeltaScan in patients who undergo Aortic Valve Replacement surgeryPopsoperative deliriumpostoperative confusion10012221NL-OMON49940Catharina-ziekenhuis50
招募中
不适用
Prospective study on the predictive value of the stopped-folds sign for detection of the afferent loop into which the enteroscope is inserted for endoscopic retrograde cholangiopancreatography in cases with Roux-en-Y reconstructioPancreatobiliary diseases requiring ERCPJPRN-UMIN000038326Sendai City Medical Center30
进行中（未招募）
不适用
Exploratory study to assess the predictive value of 99mTc-labeled albumin spheres for the intrahepatic distribution of 90Y SIR Spheres in patients with liver metastases of colorectal tumors. - ExplosiveIn addition to the assessment of shunt volumes, the intrahepatic distribution of MAA may allow for prediction of tumor radiation dose and the radiation dose to normal liver tissue. Even though MAA might be suitable for this purpose, recent results question the value of MAA. Using Bremsstrahlen imaging it was demonstrated that the intrahepatic distribution of SIR spheres and MAA differ considerably. The reason for the different deposition pattern of MAA vs. SIR spheres is currently not clear.MedDRA version: 9.1Level: LLTClassification code 10024700Term: Liver metastasesEUCTR2008-005609-21-DEFaculty For Medicine, Otto-von-Guericke University Magdeburg
招募中
不适用
A prospective study assessing the predictive value of testing stool for blood prior to capsule endoscopy for the investigation of iron deficiency anaemia or obscure gastrointestinal bleedingObscure Gastrointestinal BleedingIron deficiency AnaemiaOral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colonACTRN12609000916246St Vincent's Hospital - Melbourne50