Effect of Preoperative Supplementation in Insulin Resistance
Phase 4
Completed
- Conditions
- Liver Disease
- Registration Number
- NCT00657124
- Lead Sponsor
- Kochi University
- Brief Summary
To elucidate the effect of preoperative supplementation of carbohydrate and branched-chain amino acids on postoperative insulin resistance in patients undergoing hepatic resection, we set a randomized trial.
- Detailed Description
Twenty-six patients with hepatectomy due to a live tumor were prospectively randomized to receive a preoperative supplementation with carbohydrate and branched-chain amino acids-enriched nutrient or not.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 26
Inclusion Criteria
- The present study employed 26 patients, who underwent elective liver resection for hepatocellular carcinoma or adenocarcinoma.
Exclusion Criteria
- body weight loss greater than 10 per cent during 6 months prior to the surgery
- distant metastasis
- or seriously impaired function of vital organs due to respiratory, renal or heart disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method to evaluate the total amount of insulin required for glycemic control after hepatic resection total amount of insulin required
- Secondary Outcome Measures
Name Time Method to investigate the trends of postoperative blood glucose levels and the incidence of severe hypoglycemia (< 40 mg/dL) by using artificial pancreas during intensive care unit stay hypoglycemia
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie preoperative carbohydrate and branched-chain amino acid supplementation in hepatic resection patients?
How does preoperative Aminolevan EN supplementation compare to standard-of-care in reducing postoperative insulin resistance in liver disease patients?
Are there specific biomarkers that predict response to preoperative branched-chain amino acid supplementation in hepatectomy patients?
What are the potential adverse events associated with preoperative carbohydrate and branched-chain amino acid supplementation in liver surgery?
What combination therapies or alternative dietary supplements are being explored alongside preoperative insulin resistance management in hepatic resection patients?
Trial Locations
- Locations (1)
Kochi Medical School
🇯🇵Nankoku-City, Kohasu-Okocho, Japan
Kochi Medical School🇯🇵Nankoku-City, Kohasu-Okocho, Japan