To explore the intervention effect of Xiaoyu Xiezhuo Yin on chronic cyclosporin nephropathy in patients with aplastic anemia based on autophagy and ACE2-Ang(1-7)-Mas axis
- Conditions
- Chronic cyclosporine nephropathy
- Registration Number
- ITMCTR2000004187
- Lead Sponsor
- The First Affiliated Hospital of ZheJiang Chinese Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
1. Meet the diagnostic criteria for aplastic anemia;
2. Meet the diagnostic criteria of chronic cyclosporin A nephropathy;
3. Meet the diagnostic criteria of TCM syndromes;
4. Patients are between 18-75 years old;
5. Aplastic anemia, infection, acidosis, electrolyte disturbance, high blood pressure, etc. are well controlled;
6. No other organ failure.
1. Those who are allergic or allergic to the known ingredients of the study drug;
2. Patients diagnosed with acute kidney injury, and patients undergoing hemodialysis and peritoneal dialysis;
3. Patients with severe damage to heart, liver, lungs and other organs, or patients with malignant tumors, active tuberculosis and other wasting diseases;
4. Those with gastrointestinal bleeding, or those who need to take other types of Chinese medicine during the test period;
5. Those who do not cooperate with treatment;
6. Those with recent history of surgery;
7. Pregnant and lactating women;
8. Researchers believe that it is inappropriate to participate in clinical trials.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method C3-II;SOD;Beclin-1;Ang(1-7);ACE;p62;MDA;Klotho;TGF- beta 1;Ang II;Serum creatinine;ACE2;
- Secondary Outcome Measures
Name Time Method Blood urea nitrogen;CysC;Uric acid;ACR;