Comparison on the Effectiveness of Regimens with Combination of Intravenous and Intra-articular Applications of Tranexamic Acid for the Significant Reduction of Blood Loss in Primary Knee Osteoarthritis undergoing Total Knee Arthroplasty: A Randomized Clinical Trial Study

Not Applicable

Recruiting

• Conditions: blood loss after total knee arthroplastyblood transfusion rate; blood loss

• Registration Number: TCTR20170503003
• Lead Sponsor: one

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-05-03
• Study Completion: 2017-10-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

- Primary osteoarthritis
- 55-85 years of age
- Platelet count of more than 100,000
- PT,PTT,INR (<1.5) within normal limits
- Cr < 1.5

Exclusion Criteria

- Patients with known genetic or acquired coagulation disorder
- Patients with renal failure, liver failure, heart failure, lung failure
- Allergy to TXA
- Patients with ischemic heart disease or arrhythmia
- Previous history of DVT, PE, Stroke
- Patient with secondary arthritis
- Active infection, Cancer, stroke

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
blood loss post operative mg/dl, ml, %/ blood sample from patient

Secondary Outcome Measures

Name	Time	Method
blood transifusion rate post operative ml, Unit/ sample from patient