Torque Teno virus quantification for the prediction of graft rejection after kidney transplantatio

• Conditions: T86.1; Z94.0; Kidney transplant failure and rejection; Kidney transplant status

• Registration Number: DRKS00012335
• Lead Sponsor: MUW

Brief Summary

Each log increase in TTV load decreased the odds for rejection by 22% (odds ratio [OR] 0.78, 95% confidence interval [CI] 0.62-0.97; P = .027) and increased the odds for infection by 11% (OR 1.11, 95% CI 1.06-1.15; P < .001). TTV was quantified at a median of 14 days before rejection was diagnosed and 27 days before onset of infection, respectively. We defined a TTV load between 1 × 106 and 1 × 108 copies/mL as optimal range to minimize the risk for rejection and infection.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-04-26
• Results First Posted: 2020-03-08
• Study Completion: 2022-01-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 800

Inclusion Criteria

kidney transplantation

Exclusion Criteria

none

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
association of TTV level and organ rejection

Secondary Outcome Measures

Name	Time	Method
association of TTV level and clinical and<br>immunological baseline characteristics, type and amount of<br>immunosuppression, medical adherence, graft function [estimated<br>glomerular filtration load (eGFR) and proteinuria], donor-specific antibodies<br>(DSA) kinetic, infectious complications and cancer, death