Gingival Crevicular Fluid Alkaline Phosphatase Activity as a Biomarker of Skeletal Maturation in Comparison to Modified Middle Phalanx of The Middle Finger (MP3) Method in a Sample of Growing Egyptian Females
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Cairo University
- Enrollment
- 92
- Locations
- 1
- Primary Endpoint
- MP3
Study Overview
Brief Summary
Determination of the pubertal growth spurt in Egyptian female patients using gingival crevicular fluid alkaline phosphatase
Detailed Description
assessment of the pubertal growth spurt in growing Egyptian female patients by using a simple, quick and easy method, through taking a gingival crevicular fluid alkaline phosphatase sample and measuring its concentration. Comparing the concentration of GCF ALP to the standardized middle phalanax of the middle finger MP3 we can predict if it can be an accurate and reliable method as skeletal growth indicator.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 7 Years to 16 Years (Child)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Gender: only female subjects will be included.
- •Age between 7-16 years old
- •Intermediate or late mixed dentition and permanent dentition
- •Good general health with absence of any nutritional problems or bony disease
- •No usage of any anti-inflammatories or antibiotics in the month preceding the study
- •Fully erupted upper and lower central incisors for sample collection
- •Good gingival and periodontal health as indicated by Probing depth (PD) values that should not exceed 3 mm for the whole dentition.
- •Willingness to participate in the study and sign the informed consent form
Exclusion Criteria
- •Male adolescent subjects
- •Periodontal and /or gingival disease
- •Systemic and/or bone disease
- •Growth abnormality
Outcomes
Primary Outcomes
MP3
Time Frame: immediately after taking x-rays
periapical x-ray of the middle phalanax of the middle finger
GCF ALP concentration
Time Frame: immediately after sample collection
concentration of gingival crevicular fluid alkaline phosphatase
Secondary Outcomes
No secondary outcomes reported
Investigators
sarah samir abdelrahman abelmaged
doctor
Cairo University