Gingival Crevicular Fluid Alkaline Phosphatase as Skeletal Growth Indicator

Completed

• Conditions: Growth Indictaor
• Interventions: Radiation: periapical xray

• Registration Number: NCT04452071
• Lead Sponsor: Cairo University

Brief Summary

Determination of the pubertal growth spurt in Egyptian female patients using gingival crevicular fluid alkaline phosphatase

Detailed Description

assessment of the pubertal growth spurt in growing Egyptian female patients by using a simple, quick and easy method, through taking a gingival crevicular fluid alkaline phosphatase sample and measuring its concentration. Comparing the concentration of GCF ALP to the standardized middle phalanax of the middle finger MP3 we can predict if it can be an accurate and reliable method as skeletal growth indicator.

Study Timeline

• Study Start: 2019-11-26
• Primary Completion: 2019-12-17
• Study Completion: 2020-01-10
• Status Verified: 2020-06
• Study First Submitted: 2020-06-26
• Study First Submitted QC: 2020-06-26
• Last Update Submitted: 2020-06-26
• Study First Posted: 2020-06-30
• Last Update Posted: 2020-06-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 92

Inclusion Criteria

1. Gender: only female subjects will be included.
2. Age between 7-16 years old
3. Intermediate or late mixed dentition and permanent dentition
4. Good general health with absence of any nutritional problems or bony disease
5. No usage of any anti-inflammatories or antibiotics in the month preceding the study
6. Fully erupted upper and lower central incisors for sample collection
7. Good gingival and periodontal health as indicated by Probing depth (PD) values that should not exceed 3 mm for the whole dentition.
8. Willingness to participate in the study and sign the informed consent form

Exclusion Criteria

1. Male adolescent subjects

2. Periodontal and /or gingival disease

3. Systemic and/or bone disease

4. Growth abnormality

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
postpubertal	periapical xray	patients born in 2006-2005-2004-2003
pubertal	periapical xray	patients born in 2010-2009-2008-2007
prepubertal	periapical xray	patients born in 2012-2011

Primary Outcome Measures

Name	Time	Method
MP3	immediately after taking x-rays	periapical x-ray of the middle phalanax of the middle finger
GCF ALP concentration	immediately after sample collection	concentration of gingival crevicular fluid alkaline phosphatase

Trial Locations

Locations (1)

Faculty of Dentistry; 🇪🇬 Cairo, Manial, Egypt