The effect of mastication on feeding center: relationship between changes in glycometabolism and hormone dynamics and central nervous system
Not Applicable
- Conditions
- Obesity population
- Registration Number
- JPRN-UMIN000031397
- Lead Sponsor
- Maxillofacial Orthognathics, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Not provided
Exclusion Criteria
They fulfilled following exclusion criteria: (i) history of metabolic, neurological, or psychiatric diseases or any eating disorders, (ii) use of any medication, (iii) current or recent efforts to lose weight, (iv) pregnant, (v) BMI > 25 kg/m2.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in cerebral blood flow dynamics after administration of glucose solution are compared and examined with or without chewing. All subjects conduct experiments on different days under chewing conditions or control conditions (without chewing). Brain function measurement is performed by functional MRI imaging.
- Secondary Outcome Measures
Name Time Method Regarding blood tests, subjects took a total of 7 blood draws before gum chewing (5 minutes before glucose administration in control experiments) and immediately after glucose administration (0), 10, 20, 30, 40 and 50 minutes . At that time, the concentrations of glucose, insulin, leptin, ghrelin, PYY (peptide YY), GLP-1 (glucagon-like peptide 1), GIP (glucose-dependent secretion stimulating polypeptide), CCK (cholecystokinin) are measured.