Use of Erythromycin in Mustard-Induced Bronchiolitis
Phase 4
Completed
- Conditions
- Bronchiolitis ObliteransAcute Obliterating Bronchiolitis
- Registration Number
- NCT00367419
- Lead Sponsor
- Baqiyatallah Medical Sciences University
- Brief Summary
We looked for the effectiveness of low-dose long-term prescription of erythromycin in mustard-induced bronchiolitis obliterans
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- Not specified
Inclusion Criteria
- Documented chemical exposure
- Clinical, spirometric and radiological findings were compatible with BO on High Resolution Computed Tomography (HRCT)
- Non-responsiveness to high dose bronchodilator therapy
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Exclusion Criteria
- Radiographic evidence of pneumonia, active tuberculosis, lung carcinoma, or an infection that necessitated the use of an antibiotic
- History of cigarette smoking and occupational exposure to toxic agents of hypersensitivity to macrolides
- History of treatment with a systemic antibiotic within 7 days before the start of the study
- Any investigational medicine within 4 weeks of the study
- History of antibiotic injection within 6 weeks before the study
- Concomitant Theophylline or Carbamazepine, unless their serum concentrations were regularly monitored
- Patients who were in the exacerbation phase of their respiratory complications
- Need to use medications interact with macrolides such as Digoxin, Theophylline and Carbamazepine
- Systemic antibiotics
- Systemic Corticosteroids
- Admission to the hospital
- Abnormal kidney or liver function
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Baqiyatallah Medical Sciences University
🇮🇷Tehran, Iran, Islamic Republic of