Granulocyte Transfusions in Hematological Patients With Febrile Neutropenia

Completed

• Conditions: Fever; Fungal Infection; Bacterial Infection; Hematological Neoplasms; Neutropenia; Sepsis; Fever of Unknown Origin

• Registration Number: NCT02544230
• Lead Sponsor: Sorveglianza Epidemiologica Infezioni Fungine Emopatie Maligne

Brief Summary

The investigators retrospectively evaluated the efficacy of granulocyte transfusions as adjunctive treatment for severe infections in neutropenic fever unresponsive to antimicrobial therapy in hematological patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-01
• Primary Completion: 2011-12
• Study Completion: 2011-12
• Status Verified: 2015-09
• Study First Submitted: 2015-09-04
• Study First Submitted QC: 2015-09-05
• Last Update Submitted: 2015-09-05
• Study First Posted: 2015-09-09
• Last Update Posted: 2015-09-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 101

Inclusion Criteria

• fever;
• presence of absolute neutrophil count <0.5 x 10^9/L
• evidence of bacterial or fungal infections (including clinical signs of infection, positive cultures or biopsy, and radiological evidences)
• unresponsiveness to appropriate antimicrobial therapy for at least 48 hours

Exclusion Criteria

• none

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Infection-related mortality	within 30 days after the last granulocyte transfusion	deaths due to infection occurred within 30 days after the last granulocyte transfusion

Trial Locations

Locations (1)

Catholic University of Sacred Heart; 🇮🇹 Rome, Italy