Hepatitis B Virus Infection After Liver Transplantation in Children
- Conditions
- Hepatitis B Infection
- Registration Number
- NCT03865966
- Lead Sponsor
- Qiu Li
- Brief Summary
China is a highly prevalent area of hepatitis B virus（HBV） infection, with at least 75 million hepatitis B virus carriers, and 80% of primary hepatocellular carcinoma (HCC) is associated with chronic hepatitis B virus infection. Liver transplantation is currently the preferred method for end-stage liver disease such as biliary atresia and cirrhosis in children. In recent years, children's liver transplantation has developed rapidly and the number of developments has increased significantly. If there is chronic hepatitis B virus infection in the donor liver, it may cause HBV transmission, or the patient may have a low-load occult hepatitis B virus infection, and after immunosuppressive treatment, it may lead to hepatitis B virus infection after surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 100
- Patients with end-stage liver disease who require liver transplantation
- Children without liver transplantation refer to children;
- Children who are unwilling to participate;
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The rate of overt hepatitis b virus infection 3-5 years Clinical follow-up testing for overt HBV infection after liver transplantation in children
The rate of occult hepatitis b virus infection 3-5 years Clinical follow-up testing for occult HBV infection after liver transplantation in children
- Secondary Outcome Measures
Name Time Method The levels and changes of anti-HBs after liver transplantation 3-5 years Clinical follow-up testing for HBV seromarkers after liver transplantation in children
Trial Locations
- Locations (1)
Chongqing Children's Hospital of Chongqing Medical University
🇨🇳Chongqing, Chongqing, China