Clinical Follow-up Study on Hepatitis B Virus Infection After Liver Transplantation in Children
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- The rate of overt hepatitis b virus infection
研究概览
简要总结
China is a highly prevalent area of hepatitis B virus（HBV） infection, with at least 75 million hepatitis B virus carriers, and 80% of primary hepatocellular carcinoma (HCC) is associated with chronic hepatitis B virus infection. Liver transplantation is currently the preferred method for end-stage liver disease such as biliary atresia and cirrhosis in children. In recent years, children's liver transplantation has developed rapidly and the number of developments has increased significantly. If there is chronic hepatitis B virus infection in the donor liver, it may cause HBV transmission, or the patient may have a low-load occult hepatitis B virus infection, and after immunosuppressive treatment, it may lead to hepatitis B virus infection after surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with end-stage liver disease who require liver transplantation
排除标准
- •Children without liver transplantation refer to children;
- •Children who are unwilling to participate;
结局指标
主要结局
The rate of overt hepatitis b virus infection
时间窗: 3-5 years
Clinical follow-up testing for overt HBV infection after liver transplantation in children
The rate of occult hepatitis b virus infection
时间窗: 3-5 years
Clinical follow-up testing for occult HBV infection after liver transplantation in children
次要结局
- The levels and changes of anti-HBs after liver transplantation(3-5 years)
研究者
Qiu Li
Principal Investigator
Children's Hospital of Chongqing Medical University