A prospective, randomized, double blind, two arms, comparative clinical study to evaluate the safety and efficacy of Nixoderm tin in the management of acne vulgaris in adult subjects.

Acne vulgaris is a common cutaneous inflammatory disorder of the pilosebaceous unit, which runs a chronic course. The condition commonly manifests with papules, pustules, or nodules primarily on the face, although it can also affect the upper arms, trunk, and back. The pathogenesis of acne vulgaris involves the interaction of multiple factors that ultimately lead to the formation of its primary lesion, which is known as "comedo". Although acne vulgaris is commonly observed among adolescents, it is not restricted to this age group and can affect individuals of various ages. The severity of this condition can vary, ranging from a mild presentation with only a few comedones to more severe forms characterized by disfiguring inflammatory manifestations, which can lead to hyperpigmentation, scarring, and adverse psychological effects.Acne vulgaris is commonly observed in adolescents and young adults. Its prevalence rates are estimated to range from 35% to over 90% among adolescents. The natural course of this disease can commence as early as ages 7-12 (preadolescent acne) and resolve by the third decade of an individual’s life. However, there are instances where acne can persist into adulthood or even develop for the first time during adulthood.