Variability in bleeding phenotype in patients with hemophilia A.

Completed

• Conditions: coagulation disorder; hemophilia A; 10064477; 10005330

• Registration Number: NL-OMON33172
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 84

Inclusion Criteria

Severe hemophilia A
Most mild or most severe phenotype.
Age 18 years or older

Exclusion Criteria

Alcohol abuse.
Use of medication which is known to influence platelet function
Drug use (cannabis).

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To investigate the association of platelet responsiveness (EC50 of CRP<br /><br>stimulation, iloprost inhibition, and ADP stimulation) with clinical phenotype<br /><br>in patients with severe hemophilia A.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To investigate the association of systemic platelet activation with clinical<br /><br>phenotype in patients with severe hemophilia A.</p><br>