Rehabilitation of Everyday Memory Impairment in Parkinson Disease: A Pilot Study

Washington University School of Medicine1 site in 1 country74 target enrollmentJune 2011

Overview

Brief Summary

Cognitive impairment is common among non-demented individuals with Parkinson disease (PD) and is a significant source of disability and reduced quality of life. Unfortunately, there are no successful interventions to address these impairments. Prospective memory impairment is a particularly functionally- and clinically-relevant problem in PD. The investigator's project will determine if a targeted intervention strategy improves PD participants' prospective memory. The investigator's goal is to improve PD patients' everyday prospective memory so they can successfully perform desired activities and roles.

Detailed Description

Cognitive impairment is common among non-demented individuals with Parkinson disease (PD) and is a significant source of disability and reduced quality of life. Unfortunately, there are no successful interventions to address these impairments. Prospective memory impairment is a particularly functionally- and clinically-relevant problem in PD. The investigator's project will determine if a targeted intervention strategy improves PD participants' prospective memory. The investigator will use a randomized controlled design and a laboratory-based assessment of prospective memory to test the effect of the strategy in a controlled environment. The investigator will also see if PD participants, with support from an occupational therapist (OT), can generalize the strategy to their complex, real-world environments and tasks. Our goal is to improve PD patients' everyday prospective memory so they can successfully perform desired activities and roles.

Registry

clinicaltrials.gov

Start Date

June 2011

End Date

May 2014

Last Updated

10 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Washington University School of Medicine

Responsible Party

Principal Investigator

Erin Foster

Assistant Professor of Occupational Therapy, Neurology and Psychiatry

Washington University School of Medicine

Eligibility Criteria

Inclusion Criteria

•Participants will be males and females over age 50 who meet criteria for idiopathic typical PD, are Hoehn \& Yahr39 stage I-III (mild-moderate disease) and are treated with levodopa/carbidopa.

Exclusion Criteria

•Possible dementia,
•treatment with certain medications that interfere with cognition (e.g., anticholinergics),
•change in medications over the study period, other neurological disorders, brain surgery (e.g., STN DBS),
•history of psychotic disorder or significant current psychiatric disorder, or any condition that would interfere with testing (e.g., vision problems).