EUCTR2016-005013-47-SE进行中（未招募）1 期
Effects of the FAAH inhibitor PF-04457845 on fear extinction in healthy volunteers - PF-04457845 and fear extinction
inköping University0 个研究点开始时间: 2017年1月3日最近更新:
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •Age >18 years, and willing to provide informed consent.
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 60
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •Lifetime diagnosis of psychosis or bipolar disease, current axis 1 diagnosis; as determined by a history, clinical examination and MINI interview carried out by appropriately trained staff
- •Ongoing (within the last month) psychiatric medication
- •Current (within the last month) use of illicit drugs, as identified using the Drug Use Disorder Identification Test (DUDIT).
- •Co-medication with CYP3A inhibitors, CYP3A inducers or P-glycoprotein substrates.
- •Any other current medication or medical condition that in the judgment of the investigator could interfere with treatment.
- •Pregnancy or nursing. To be eligible, women of childbearing potential (WOCBP) must have a negative serum or urine pregnancy test prior to the start of study drug. WOCBP and males with WOCBP partners must agree to use a method of contraception that is highly effective for the duration of the study and for at least 28 days after the intake of the study drug. A highly effective method of birth control is defined as one which results in a low failure rate (i.e. less than 1% per year) when used consistently and correctly, such as implants, injectables, combined oral contraceptives, some IUDs, sexual abstinence or vasectomised partner.
- •Clinically significant deviations from normal range of physiological functions as determined by a specialist consult when needed (blood pressure, heart rate, AST, ALT, GGT, WBC with differential, Hb, MCV, TPK, LPK and CRP).
- •Due to the nature of the tasks, we will also exclude anyone with hearing impairments.
研究者
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