Angiotensin- (1-7) supplementation in physical exercise practitioners
- Conditions
- Sedentary BehaviorF01.145
- Registration Number
- RBR-2nbmpbc
- Lead Sponsor
- aboratório de Fisiologia do Exercício
- Brief Summary
Angiotensin-(1-7) supplementation has received attention because of its possible ergogenic effects on physical performance. The effects of a single dose of Ang-(1-7) on the performance of mountain bike athletes (MTB) during progressive load tests performed until voluntary fatigue have been previously demonstrated. This study tested the effects of Ang-(1-7) in two different exercise protocols with distinct metabolic demands: aerobic (time trial) and anaerobic (repeated sprint). Methods: 21 male recreational athletes ingested capsules containing an oral formulation of HPßCD-Ang-(1-7) (0.8 mg) and HPßCD-placebo (only HPßCD) with 7 days interval, the double-blind randomized crossover design were use. Physical performance was examined by two protocols a 20-km cycling time trial or 4 x 30-s repeated all-out sprints on a leg cycle ergometer. Data were collected pre and post physical testing to assess fatigue parameters including lactate,Muscle activation during the sprint protocol was assessed using electromyography (EMG); cardiovascular parameters: Diastolic and systolic blood pressure and heart rate; for performance parameters were assed time to complete (time trial), max power and mean power (repeated sprint) . Results: Supplementation with an oral formulation HPßCD-Ang-(1-7) reduced basal plasma lactate levels and promoted the maintenance of plasma glucose levels after repeated sprints. Supplementation with HPßCD-Ang-(1-7) also increased baseline plasma nitrite levels and reduced resting diastolic blood pressure in the time-trial protocol. HPßCD-Ang-(1-7) had no effect on time trial or repeated sprint performance and EMG recordings of the vastus lateralis and vastus medialis. Conclusion: Supplementation with HPßCD-Ang-(1-7) did not improve physical performance in the time trial and repeated sprints. However, it promoted the maintenance of plasma glucose levels after the sprint protocol and plasma lactate levels at rest. In addition, HPßCD-Ang-(1-7) also increased resting plasma nitrite levels and reduced diastolic blood pressure in the time trial protocol.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Male
- Target Recruitment
- Not specified
Athletes and practitioners of physical exercise; older than 18 years; involved in their training programs for at least one year; have participated in competition in the last six months at the regional level
Present some type of illness that compromises data collection; individuals with any type of pathology; smokers; make use of medications such as anti-inflammatories and antibiotics and / or others that may compromise research data; as well as supplements that interfere with cardiovascular parameters such as caffeine and guarana
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method