Clinical Course of Cancer Patients Who Contracted COVID 19 Infection: An Observational Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- describe cancer patients with COVID-19 and their clinical course
研究概览
简要总结
It's an obsevational retrospective/prospective study. Analyzing the evolution of COVID 19 infection in cancer patients can provide interesting information in the management of these patients. For this reason, the purpose of this study is to implement a registry to describe and monitor cancer patients affected by COVID 19, the factors that are associated with an unfavorable evolution, to develop a strategy for the risk assessment of these patients and recommendations. relating to their treatment.
Particular attention will be paid to patients suffering from urological tumors because the treatment followed by the patients would seem to expose them to a greater risk when they are infected with coronavirus, furthermore, from the literature it is clear that there may be a connection between sex hormones and ACE2 levels in the plasma. In fact, the estrons up-regulate the concentration of ACE2 in the circulation and this could be the reason why women would seem more protected than men once they contract the coronavirus infection
详细描述
Primary objectives:
- describe cancer patients with COVID-19 and their clinical course;
- identify predictors of the most severe clinical course;
- identify prognostic factors; Secondary objectives
- Monitor patients with urological tumors with particular attention;
- Dosing parameters of inflammation such as IL-6 and IFNα;
- Measure the ACE2 levels.
Patients with oncological pathology who contracted COVID 19 infection from January 1, 2020 until the WHO declaration of the end of the pandemic will be studied.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •confirmation of COVID-19 in the laboratory (RT-PCR techniques);
- •suspected cases of COVID-19; clinically diagnosed based on symptoms (fever> 37.5 °, decrease in oximeter saturation by at least 5%, cough, diarrhea, otitis, dysgeusia, myalgia, arthralgia, conjunctivitis and rhinorrhea) + close contact a COVID-19 subject positive;
- •asymptomatic cases; diagnosed based on positive swab results but without symptoms even dead patients
排除标准
- 未提供
结局指标
主要结局
describe cancer patients with COVID-19 and their clinical course
时间窗: Almost 1 year
Describing cancer patients with COVID-19 and their clinical course will help us to identify predictors of the most severe clinical course and also prognostic factors
次要结局
未报告次要终点