Effect of a Third COVID-19 Booster Among Health Care Workers

Completed

• Conditions: COVID-19 Vaccines
• Interventions: Biological: Third COVID-19 booster

• Registration Number: NCT05373459
• Lead Sponsor: Hong Kong Sanatorium & Hospital

Brief Summary

A new wave of COVID-19 infections, mainly caused by the Omicron/ Delta variant, has been sweeping the globe since the start of 2022. In response, the administration of a third dose of COVID-19 vaccine was considered to address potential waning immunity over time and reduced effectiveness against the Omicron/ Delta variant. The pandemic also resulted in many infections among health care workers (HCWs) and their households. In this study, a retrospective analysis would perform on risk of COVID-19 infection and their outcome in relation to their COVID-19 vaccination history by using the data repository from one of the Hong Kong private hospitals.

HCWs were required to submit a standardized online self-declaration form for report of 1) demographic of the HCWs, 2) symptoms related history and 3) COVID-19 exposure history once they were COVID-19 confirmed by rapid antigen test against COVID-19 and/or polymerase chain reaction (PCR) test for COVID-19. Subsequent follow up such as contact tracing, COVID-19 PCR testing results of these HCWs and status of return to work were captured by the infection control team in a systematic manner.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-05-12
• Study First Submitted QC: 2022-05-12
• Study First Posted: 2022-05-13
• Study Start: 2022-05-16
• Primary Completion: 2022-12-31
• Study Completion: 2022-12-31
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-26
• Last Update Posted: 2024-02-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 3167

Inclusion Criteria

• All full time staff members of the private hospital

Exclusion Criteria

• History of COVID-19 before 2022

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
HCWs with third COVID-19 booster	Third COVID-19 booster	Health care workers received at least 3 doses of COVID-19 vaccine

Primary Outcome Measures

Name	Time	Method
COVID-19 Infection	During 1 February - 31 March 2022	Number of participants with COVID-19 infected
Number of days return to work after COVID-19 infection	During 1 February - 31 March 2022	Number of days return to work after COVID-19 infection

Trial Locations

Locations (1)

Hong Kong Sanatorium & Hospital; 🇭🇰 Hong Kong, Hong Kong