DRKS00023456尚未招募不适用
The influence of the oral microbiome on the pathophysiology of Alzheimer's disease - IT-TEMP-17
Deutsche Alzheimer Gesellschaft e. V. Selbsthilfe Demenz, vertreten durch die Geschäftsführerin0 个研究点目标入组 60 人开始时间: 2020年11月30日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 66 Years 至 one（—）
- 性别
- All
入选标准
- •Women and men (> 65 years) with mild AD (MMST = 20)
- •- Women and men (> 65 years) with MCI and a pathological CSF profile (Aß1-42 decreased, tau protein increased)
- •- Women and men (> 65 years) as healthy control subjects (MMST> 27)
- •- Obtained consent and information ability
- •- Willingness to take swabs of the oral mucosa and gums
排除标准
- •- Acute infections of the upper respiratory tract
- •- Known acute inflammations in the oral cavity (e.g. stomatitis)
- •- Serious physical illnesses with impairment of the general condition, fever or current weight loss of more than 2 kg in the past four weeks, palliative life situation
- •- Malnutrition (body mass index below 18.5 kg / m2)
- •- Other neurological diseases (stroke, multiple sclerosis, epilepsy, Parkinson's disease) or severe psychiatric comorbidities such as an addiction disorder or schizophrenic psychosis
- •- Potentially reversible causes of cognitive deficits (e.g. vitamin B12 deficiency)
研究者
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