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Clinical Trials/DRKS00023456
DRKS00023456
Not yet recruiting
Not Applicable

The influence of the oral microbiome on the pathophysiology of Alzheimer's disease - IT-TEMP-17

Deutsche Alzheimer Gesellschaft e. V. Selbsthilfe Demenz, vertreten durch die Geschäftsführerin0 sites60 target enrollmentNovember 30, 2020
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ConditionsF00.0F00.1Dementia in Alzheimer disease with early onsetDementia in Alzheimer disease with late onset

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
F00.0
Sponsor
Deutsche Alzheimer Gesellschaft e. V. Selbsthilfe Demenz, vertreten durch die Geschäftsführerin
Enrollment
60
Status
Not yet recruiting
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
November 30, 2020
End Date
TBD
Last Updated
last year
Study Type
Observational
Sex
All

Investigators

Sponsor
Deutsche Alzheimer Gesellschaft e. V. Selbsthilfe Demenz, vertreten durch die Geschäftsführerin

Eligibility Criteria

Inclusion Criteria

  • •Women and men (\> 65 years) with mild AD (MMST \= 20\)
  • •\- Women and men (\> 65 years) with MCI and a pathological CSF profile (Aß1\-42 decreased, tau protein increased)
  • •\- Women and men (\> 65 years) as healthy control subjects (MMST\> 27\)
  • •\- Obtained consent and information ability
  • •\- Willingness to take swabs of the oral mucosa and gums

Exclusion Criteria

  • •\- Acute infections of the upper respiratory tract
  • •\- Known acute inflammations in the oral cavity (e.g. stomatitis)
  • •\- Serious physical illnesses with impairment of the general condition, fever or current weight loss of more than 2 kg in the past four weeks, palliative life situation
  • •\- Malnutrition (body mass index below 18\.5 kg / m2\)
  • •\- Other neurological diseases (stroke, multiple sclerosis, epilepsy, Parkinson's disease) or severe psychiatric comorbidities such as an addiction disorder or schizophrenic psychosis
  • •\- Potentially reversible causes of cognitive deficits (e.g. vitamin B12 deficiency)

Outcomes

Primary Outcomes

Not specified

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