NCT03540940CompletedNot Applicable
The Effect of Positive End-expiratory Pressure During Induction of General Anesthesia on Atelectasis Formation and Non-hypoxic Apnea Time in Small Children: a Randomized Controlled Trials
Seoul National University Hospital4 sites in 1 country60 target enrollmentStarted: May 21, 2018Last updated:
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 60
- Locations
- 4
- Primary Endpoint
- Duration of Apnea
Study Overview
Brief Summary
Positive end-expiratory pressure (PEEP) applied during induction of anesthesia prevents atelectasis formation and increases the duration of nonhypoxic apnea in obese and nonobese patients. PEEP also prevents atelectasis formation in pediatric patients. Because pediatric patients arterial desaturation during induction of anesthesia develops rapidly, we studied the clinical benefit of PEEP applied during anesthesia induction.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Supportive Care
- Masking
- None
Eligibility Criteria
- Ages
- 1 Month to 2 Years (Child)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •pediatric patients undergoing general anesthesia using endotracheal intubation
Exclusion Criteria
- •previous history of lung disease
- •anticipated difficulty in airway management
Arms & Interventions
zero positive end expiratory pressure
Experimental
Intervention: ZEEP (Other)
Positive end expiratory pressure
Experimental
Intervention: PEEP (Other)
Outcomes
Primary Outcomes
Duration of Apnea
Time Frame: from the start of apnea until SpO2 reached 95%, maximum 5 minutes.
Secondary Outcomes
No secondary outcomes reported
Investigators
Hee-Soo Kim
professor
Seoul National University Hospital
Study Sites (4)
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