Insulin Resistance Indices and Coronary Artery Disease

Completed

• Conditions: Coronary Artery Disease; Insulin Resistance
• Interventions: Diagnostic Test: triglyceride to glucose ratio; Diagnostic Test: triglycerdie to HDL ratio

• Registration Number: NCT06237244
• Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary

In this retrospective study from professor Kojuri clinic registry, total number of 1017 patients with first angiography were included and all data were recorded from registry. Insulin resistance was calculated using laboratory data

Detailed Description

This was an analytical cross-sectional retrospective study involving patients with suspected CAD who underwent coronary angiography between December 2018 and May 2023. The information was obtained from patients referred to the outpatient cardiovascular clinic (Professor Kojuri Cardiology Clinic, Shiraz, Iran, www.kojuriclinic.com). Data was extracted from Professor Kojuri Cardiology Clinic database, including patient's information about the clinical history, presence or absence of specific diseases, angiography/angioplasty results, medications, and laboratory values.

A total of 14,708 patients who had undergone coronary angiography at least once were examined. After applying exclusion criteria, 1017 eligible cases were selected for data analysis.

The following data was recorded for the included patients: demographic data, past medical history (such as DM, hypertension, etc.), systolic and diastolic blood pressure, weight and height, fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and serum creatinine (Cr). Body mass index (BMI) was calculated as weight (Kg) divided by the square of height (m2). Obesity was defined as BMI ≥ 30 Kg/m2.

Laboratory values were selected from the time before angiography, and if not available, from the time shortly after the angiography. This helped us find those values which could best represent the metabolic state of patients at the time of angiography, while reducing the confounding effect of statin use.

Study Timeline

• Study Start: 2018-12-01
• Primary Completion: 2023-05-01
• Study Completion: 2023-09-01
• Study First Submitted: 2024-01-23
• Study First Submitted QC: 2024-01-23
• Status Verified: 2024-02
• Study First Posted: 2024-02-01
• Last Update Submitted: 2024-02-02
• Last Update Posted: 2024-02-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1017

Inclusion Criteria

• patients with age more than 18 years and having undergone coronary angiography

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Exclusion Criteria

• incomplete data
• history of prior coronary angiography or revascularization (percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG))
• serum creatinine > 1.4 mg/dL
• history of chronic kidney disease (CKD)
• cancer,

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
coronary artery disease	triglycerdie to HDL ratio	patients with coronary angiography of at least one vessel with more than 50% stenosis
no coronary artery disease	triglyceride to glucose ratio	patient with no stenosis in coronary angiography
coronary artery disease	triglyceride to glucose ratio	patients with coronary angiography of at least one vessel with more than 50% stenosis
no coronary artery disease	triglycerdie to HDL ratio	patient with no stenosis in coronary angiography

Primary Outcome Measures

Name	Time	Method
insulin resistance index: Level of triglyceride to HDL ratio from blood sample	3 years	correlation of coronary artery disease and triglyceride to HDL level ratio in blood laboratory sample
insulin resistance index: level of triglyceride to glucose ratio from blood sample	3 years	correlation of coronary artery disease and triglyceride glucose ratio in blood laboratory tests

Secondary Outcome Measures

Name	Time	Method
metabolic syndrome	3 years	metabolic syndrome based on criteria of metabolic syndrome

Trial Locations

Locations (1)

Shiraz University of Medical Sciences; 🇮🇷 Shiraz, Fars, Iran, Islamic Republic of