Acute Kidney Injury After Cardiac Arrest

Completed

• Conditions: Acute Kidney Injury

• Registration Number: NCT06544538
• Lead Sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Brief Summary

The development of AKI (Acute Kidney Injury) after cardiac arrest is a common factor associated with mortality. In this study, we aimed to evaluate the factors that increase the risk of developing AKI after cardiac arrest.

For the study, patients were evaluated for the incidence of acute kidney injury (AKI), factors that increase the risk of AKI, and the impact of AKI on mortality. In this process, demographic data, comorbidities, hemodynamic data, laboratory data, clinical symptoms and findings recorded in the electronic decision support system were recorded and analyzed.

Detailed Description

This retrospective study was performed on patients hospitalized in intensive care units after cardiac arrest between 2013 and 2022. Patients who met the inclusion criteria were included in the study. Urea, creatinine values, and whether AKI was diagnosed or not were obtained from the data registry system. Statistical evaluation was performed using univariate binary logistic regression analysis.

Demographic data, location of cardiac arrest (in-hospital, out-of-hospital), and duration of CPR were recorded. In addition, the causes of cardiac arrest, HR/MAP (heart rate/average arterial pressure) ratio, and whether VSP (vasopressor) or INO (inotropic) medication was needed were recorded.

Study Timeline

• Study Start: 2013-01-01
• Primary Completion: 2022-12-31
• Study Completion: 2022-12-31
• Study First Submitted: 2024-07-27
• Status Verified: 2024-08
• Study First Submitted QC: 2024-08-05
• Last Update Submitted: 2024-08-05
• Study First Posted: 2024-08-09
• Last Update Posted: 2024-08-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 82

Inclusion Criteria

• adult patients with spontaneous circulation after cardiac arrest and admitted to the intensive care unit

Exclusion Criteria

• Deaths in the first 48 hours

• Missing data

• End stage CKD or first day hemadsorption

• CPR time <3 min

• Unwitnessed cardiac arrest

• Terminal malignancy

  • 90 years old

• Having a pace marker

• Massive bleeding

• ECMO application

• First day diyabetes insipitus

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acute Kidney Injury (AKI)	Within 48 hours after intensive care unit admission	Creatinine values in the first 48 hours of intensive care unit admission after cardiac arrest

Secondary Outcome Measures

Name	Time	Method
Mortality	Clinical and laboratory data within 48 hours after intensive care unit admission will be used	Impact of AKI development on mortality in the early post-cardiac arrest period
AKI incidence	Within 48 hours after intensive care unit admission	Determination of the incidence of AKI development after cardiac arrest

Trial Locations

Locations (1)

Bakırköy Dr. Sadi Konuk Training and Research Hospital; 🇹🇷 Istanbul, Turkey