Early Detection of Prostate Cancer in Firefighters - a Register-based Study of Prognostic Factors and Survival
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 137,536
- 试验地点
- 1
- 主要终点
- Cause-specific mortality rate for prostate cancer
研究概览
简要总结
Firefighters, police, military personnel and pilots are all shown to have a higher incidence of prostate cancer than the general population. A possible explanation for this is that these four groups of employees need regular mandatory health-checkups. If these checkups increase the chances of having a PSA or DRE performed one could expect the workers in question to have a higher probability than the general population of being diagnosed with prostate cancer. If this is the case the four groups should have cancers that are lower grade and have better survival. The investigators wish to examine this by comparing the four groups with a control group made up of all other workers with regards to prognostic factors at the time of diagnosis and survival rates. This will be done by extracting data from the Cancer Registry of Norway, coupled with employment data from Statistics Norway. This study is also a part of a project on cancer in firefighters. If the prostate cancers in firefighters differ significantly from the other three specified groups, this could point to an exposure specific for firefighters, e.g. fire smoke, as an etiologic factor.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •All cases of prostate cancer as registered by the Cancer Registry of Norway
排除标准
- 未提供
结局指标
主要结局
Cause-specific mortality rate for prostate cancer
时间窗: From January 1st 1960 until December 31st 2018
次要结局
- TNM staging(January 1st 1960 until December 31st 2018)
- Gleason score(January 1st 1960 until December 31st 2018)
- PSA at time of diagnosis(January 1st 1960 until December 31st 2018)
- Functional status at time of diagnosis (WHO classification)(January 1st 1960 until December 31st 2018)
研究者
Jarle Jakobsen
PhD-student
Norwegian Institute of Public Health
