A randomized trial of Rituximab in induction therapy for living donor renal transplantation - Randomized trial of rituximab in renal transplantation

Guys and St Thomas Foundation Trust0 个研究点开始时间: 2010年3月17日最近更新: 2014年10月7日

适应症

试验速览

暂无简介。

•Adult patients over 18 years receiving their first living donor renal transplant, or their second if the first was not lost from acute rejection.
•Patients who have given written informed consent.
•If female and of child bearing potential, taking adequate contraception.
•Are the trial subjects under 18? no
•Number of subjects for this age range: 0
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 0
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 0

•Previous other organ transplants lost through acute rejection
•Patients undergoing antibody removal.
•Patients with other organ transplants.
•Patients previously treated with cylophosphamide, ATG, OKT3 or rituximab.
•Patients with white cell count below 3.6x10^9/L; Inclusion of patients with white blood cell counts less than 4.0x10^9/L, but higher than 3.6x10^9/L will be left to the discretion of the Principal Investigator.
•Patients with platelet count below 100x10^9/L
•Patients who are treated with drugs that are known to have clinically significant interactions with tacrolimus and those treated with with terfenadine, astemizole, cisapride or lovastatin.
•Patients who have been involved in any other investigational trial or non protocol immunosuppressive regimen in the previous 90 days prior to transplant.
•Pregnant or breastfeeding women
•Patients with a documented history of malignancy and its origins and treatment in the last five years. Localised basal cell carcinoma of the skin is permitted
•Patients known to be HIV, Hepatitis B surface antigen or Hepatitis C antibody positive.
•Prisoners or young offenders.
•Patients who in the opinion of the Investigator would not be a suitable candidate for study participation.
•Women of child bearing potential not willing to take adequate contraception.

发起方

Guys and St Thomas Foundation Trust